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Iron Metabolism Regulation in Females and Males Exposed to Simulated Microgravity: results from the Randomized Trial AGBRESA

Horeau, M. and Report, M. and Mulder, E. and Tank, J. and Frings-Meuthen, P. and Armbrecht, G. and Loréal, O. and Derbré, F. (2022) Iron Metabolism Regulation in Females and Males Exposed to Simulated Microgravity: results from the Randomized Trial AGBRESA. American Journal of Clinical Nutrition, 116 (5), pp. 1430-1440. American Society for Nutrition. doi: 10.1093/ajcn/nqac205. ISSN 0002-9165.

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Official URL: https://doi.org/10.1093/ajcn/nqac205

Abstract

Background: Iron metabolism imbalance could contribute to physical deconditioning experienced by astronauts due to its essential role in energy metabolism, cellular respiration, and oxygen transport. Objectives: In this clinical exploratory study, we wanted to determine whether artificial gravity (AG) training modulated iron metabolism, red blood cell indices, and body lean mass in male and female healthy participants exposed to head-down tilt (HDT) bed rest, the reference ground-based model of microgravity. Methods: We recruited 8 female and 16 male healthy participants who were all exposed to HDT bed rest for 60 days. In addition, they were assigned to three experimental groups (n = 8/each): controls, continuous AG training in a short-arm centrifuge (1×30 min/day), and intermittent AG training (6 × 5 min/day). Results: The iron metabolism responses to simulated microgravity of AG training groups do not significantly differ from the responses of controls. Independently from AG, we found that both serum iron (+31.3%, P = 0.027) and transferrin saturation levels (+28.4%, P = 0.009) increased in males after 6 days of HDT bed rest, as well as serum hepcidin levels (+36.9% P = 0.005). The increase of transferrin saturation levels persisted after 57 days of HDT bed rest (+13.5%, P = 0.026), suggesting that long-term exposure to microgravity sustainably increases serum iron availability in males, and consequently the risk of iron excess or misdistribution. In females, 6 and 57 days of HDT bed rest did not significantly change serum iron, transferrin saturation, and hepcidin levels. Conclusions: The data from this exploratory study suggest that 1) AG training does not influence the iron metabolism responses to microgravity; 2) iron metabolism parameters, especially iron availability for cells, are significantly increased in males, but not in females, exposed to long-term simulated microgravity. Due to the small sample size of females, we nevertheless must be cautious before concluding that iron metabolism could differently respond to microgravity in females. Clinical trial registry number: DRKS00015677.

Item URL in elib:https://elib.dlr.de/190343/
Document Type:Article
Title:Iron Metabolism Regulation in Females and Males Exposed to Simulated Microgravity: results from the Randomized Trial AGBRESA
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Horeau, M.Laboratory "Movement Sport and Health Sciences" EA7470, University of Rennes/ENS Rennes, FranceUNSPECIFIED
Report, M.INSERM, University of Rennes, INRAE, UMR 1241, AEM2 platform, Nutrition Metabolisms and Cancer (NuMeCan) institute, Rennes, France.UNSPECIFIED
Mulder, E.German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Frings-Meuthen, P.Petra.Frings-Meuthen (at) dlr.deUNSPECIFIED
Armbrecht, G.Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Radiology, Berlin, GermanyUNSPECIFIED
Loréal, O.INSERM, University of Rennes, INRAE, UMR 1241, AEM2 platform, Nutrition Metabolisms and Cancer (NuMeCan) institute, Rennes, FranceUNSPECIFIED
Derbré, F.Laboratory "Movement Sport and Health Sciences" EA7470, University of Rennes/ENS Rennes, FranceUNSPECIFIED
Date:26 August 2022
Journal or Publication Title:American Journal of Clinical Nutrition
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:116
DOI:10.1093/ajcn/nqac205
Page Range:pp. 1430-1440
Publisher:American Society for Nutrition
ISSN:0002-9165
Status:Published
Keywords:disuse; inflammation; metals; spaceflight; trace elements
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Schrage, Larissa
Deposited On:22 Nov 2022 12:32
Last Modified:22 Nov 2022 12:32

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