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Dbf4-dependent kinase (DDK) promotes resection of DNA double strand breaks and repair via homologous recombination

Galanti, Lorenzo and Peritore, Martina and Cannavo, Elda and Cejka, Petr and Pfander, Boris (2022) Dbf4-dependent kinase (DDK) promotes resection of DNA double strand breaks and repair via homologous recombination. DGDR-Krupp 2022 Symposium on DNA Repair and Human Disease, 2022-04-06 - 2022-04-09, Jena, Germany.

Full text not available from this repository.

Abstract

DNA double strand breaks (DSBs) can be repaired via different cellular mechanisms, with two types of repair: direct ligation-based mechanisms or recombination-based mechanisms, like homologous recombination (HR). Ligation-based mechanisms require little processing of the broken ends, while extensive processing via the nucleolytic degradation of the 5’-terminated broken strand (DNA end resection) is crucial to commit cells to recombination-mediated repair. HR makes use of a homologous template, preferentially the sister chromatid, to direct the repair of the DSB and is therefore upregulated in cell cycle phases where the sister chromatid is available. DNA end resection is upregulated in the same cell cycle phases as well and is under strict cell cycle control. Different resection proteins were shown to be activated during the cell cycle by cyclin-dependent kinase (CDK), in both yeast and human. However, CDK-phosphomimetic mutants of these factors does not seem to be able to bypass the cell cycle regulation of DNA end resection. This suggests that additional cell cycle kinases might be important for this regulation. [...]

Item URL in elib:https://elib.dlr.de/190288/
Document Type:Conference or Workshop Item (Poster)
Title:Dbf4-dependent kinase (DDK) promotes resection of DNA double strand breaks and repair via homologous recombination
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Galanti, LorenzoDNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Martinsried, Germany and Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Peritore, MartinaDNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Martinsried, Germany and Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Cannavo, EldaInstitute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.UNSPECIFIEDUNSPECIFIED
Cejka, PetrInstitute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland and Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, SwitzerlandUNSPECIFIEDUNSPECIFIED
Pfander, BorisUNSPECIFIEDhttps://orcid.org/0000-0003-2180-5054UNSPECIFIED
Date:2022
Refereed publication:No
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:DNA double strand breaks (DSBs), Dbf4-dependent kinase (DDK), DNA repair
Event Title:DGDR-Krupp 2022 Symposium on DNA Repair and Human Disease
Event Location:Jena, Germany
Event Type:international Conference
Event Start Date:6 April 2022
Event End Date:9 April 2022
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Radiation & Hypoxia
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:29 Nov 2022 09:58
Last Modified:24 Apr 2024 20:51

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