Galanti, Lorenzo and Peritore, Martina and Cannavo, Elda and Cejka, Petr and Pfander, Boris (2022) Dbf4-dependent kinase (DDK) promotes resection of DNA double strand breaks and repair via homologous recombination. DGDR-Krupp 2022 Symposium on DNA Repair and Human Disease, 2022-04-06 - 2022-04-09, Jena, Germany.
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Abstract
DNA double strand breaks (DSBs) can be repaired via different cellular mechanisms, with two types of repair: direct ligation-based mechanisms or recombination-based mechanisms, like homologous recombination (HR). Ligation-based mechanisms require little processing of the broken ends, while extensive processing via the nucleolytic degradation of the 5’-terminated broken strand (DNA end resection) is crucial to commit cells to recombination-mediated repair. HR makes use of a homologous template, preferentially the sister chromatid, to direct the repair of the DSB and is therefore upregulated in cell cycle phases where the sister chromatid is available. DNA end resection is upregulated in the same cell cycle phases as well and is under strict cell cycle control. Different resection proteins were shown to be activated during the cell cycle by cyclin-dependent kinase (CDK), in both yeast and human. However, CDK-phosphomimetic mutants of these factors does not seem to be able to bypass the cell cycle regulation of DNA end resection. This suggests that additional cell cycle kinases might be important for this regulation. [...]
Item URL in elib: | https://elib.dlr.de/190288/ | ||||||||||||||||||||||||
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Document Type: | Conference or Workshop Item (Poster) | ||||||||||||||||||||||||
Title: | Dbf4-dependent kinase (DDK) promotes resection of DNA double strand breaks and repair via homologous recombination | ||||||||||||||||||||||||
Authors: |
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Date: | 2022 | ||||||||||||||||||||||||
Refereed publication: | No | ||||||||||||||||||||||||
Open Access: | No | ||||||||||||||||||||||||
Gold Open Access: | No | ||||||||||||||||||||||||
In SCOPUS: | No | ||||||||||||||||||||||||
In ISI Web of Science: | No | ||||||||||||||||||||||||
Status: | Published | ||||||||||||||||||||||||
Keywords: | DNA double strand breaks (DSBs), Dbf4-dependent kinase (DDK), DNA repair | ||||||||||||||||||||||||
Event Title: | DGDR-Krupp 2022 Symposium on DNA Repair and Human Disease | ||||||||||||||||||||||||
Event Location: | Jena, Germany | ||||||||||||||||||||||||
Event Type: | international Conference | ||||||||||||||||||||||||
Event Start Date: | 6 April 2022 | ||||||||||||||||||||||||
Event End Date: | 9 April 2022 | ||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||
HGF - Program: | Space | ||||||||||||||||||||||||
HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||||||||||
DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||
DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||||||||||
DLR - Research theme (Project): | R - Radiation & Hypoxia | ||||||||||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine > Radiation Biology | ||||||||||||||||||||||||
Deposited By: | Kopp, Kerstin | ||||||||||||||||||||||||
Deposited On: | 29 Nov 2022 09:58 | ||||||||||||||||||||||||
Last Modified: | 24 Apr 2024 20:51 |
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