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A comparison between left ventricular ejection time measurement methods during physiological changes induced by simulated microgravity

Orter, S. and Möstl, S. and Bachler, M. and Hoffmann, F. and Mayer, C. and Kaniusas, E. and Reisinger, M. and Wassertheurer, S. and Tank, J. and Jordan, J. and Hametner, B. (2022) A comparison between left ventricular ejection time measurement methods during physiological changes induced by simulated microgravity. Experimental Physiology, 107 (3), pp. 213-221. Wiley. doi: 10.1113/EP090103. ISSN 0958-0670.

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Official URL: https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP090103

Abstract

New findings: What is the central question of this study? First, we validated easy-to-use oscillometric left ventricular ejection time (LVET) against echocardiographic LVET. Second, we investigated progression of left ventricular ejection time index (LVETI), pre-ejection period index (PEPI), total electromechanical systole index (QS2I) and PEP/LVET ratio during 60 days of head-down tilt (HDT). What is the main finding and its importance? The LVETosci and LVETecho showed good agreement in effect direction. Hence, LVETosci might be useful to evaluate cardiovascular responses during space flight. Moreover, the approach might be useful for individual follow-up of patients with altered ejection times. Furthermore, significant effects of 60 days of HDT were captured by measurements of LVETI, PEPI, QS2I and PEP/LVET ratio. Abstract: Systolic time intervals that are easy to detect might be used as parameters reflecting cardiovascular deconditioning. We compared left ventricular ejection time (LVET) measured via ultrasound Doppler on the left ventricular outflow tract with oscillometrically measured LVET, measured at the brachialis. Furthermore, we assessed the progression of the left ventricular ejection time index (LVETI), the pre-ejection period index (PEPI), the Weissler index (PEP/LVET) and the total electromechanical systole index (QS2I) during prolonged strict head-down tilt (HDT) bed rest, including 16 male and eight female subjects. Simultaneous oscillometric and echocardiographic LVET measurements showed significant correlation (r = 0.53 with P = 0.0084 before bed rest and r = 0.73 with P < 0.05 on the last day of bed rest). The shortening of LVET during HDT bed rest measured with both approaches was highly concordant in their effect direction, with a concordance rate of 0.96. Our results also demonstrated a significant decrease of LVETI (P < 0.0001) and QS2I (P = 0.0992) and a prolongation of PEPI (P = 0.0049) and PEP/LVET (P = 0.0003) during HDT bed rest over 60 days. Four days after bed rest, LVETI recovered completely to its baseline value. Owing to the relationship between shortening of LVETI and heart failure progression, the easy-to-use oscillometric method might not only be a useful way to evaluate the cardiovascular system during space flights, but could also be of high value in a clinical setting.

Item URL in elib:https://elib.dlr.de/190261/
Document Type:Article
Title:A comparison between left ventricular ejection time measurement methods during physiological changes induced by simulated microgravity
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Orter, S.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIEDUNSPECIFIED
Möstl, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bachler, M.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIEDUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Mayer, C.Center for Health & Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIEDUNSPECIFIED
Kaniusas, E.Institute of Electrodynamics, Microwave and Circuit Engineering, Vienna University of Technology, Vienna, AustriaUNSPECIFIEDUNSPECIFIED
Reisinger, M.Center for Health & Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIEDUNSPECIFIED
Wassertheurer, S.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIEDUNSPECIFIED
Tank, J.UNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Hametner, B.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIEDUNSPECIFIED
Date:24 January 2022
Journal or Publication Title:Experimental Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:107
DOI:10.1113/EP090103
Page Range:pp. 213-221
Publisher:Wiley
ISSN:0958-0670
Status:Published
Keywords:head-down tilt bed rest; left ventricular ejection time; oscillometry; systolic time intervals; validation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:22 Nov 2022 09:22
Last Modified:28 Jun 2023 13:58

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