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INDY as a Therapeutic Target for Cardio-Metabolic Disease

Pesta, Dominik and Jordan, Jens (2022) INDY as a Therapeutic Target for Cardio-Metabolic Disease. Metabolites, 12 (3), p. 244. Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390/metabo12030244. ISSN 2218-1989.

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Official URL: https://www.mdpi.com/2218-1989/12/3/244

Abstract

Decreased expression of the plasma membrane citrate transporter INDY (acronym I'm Not Dead, Yet) promotes longevity and protects from high-fat diet- and aging-induced metabolic derangements. Preventing citrate import into hepatocytes by different strategies can reduce hepatic triglyceride accumulation and improve hepatic insulin sensitivity, even in the absence of effects on body composition. These beneficial effects likely derive from decreased hepatic de novo fatty acid biosynthesis as a result of reduced cytoplasmic citrate levels. While in vivo and in vitro studies show that inhibition of INDY prevents intracellular lipid accumulation, body weight is not affected by organ-specific INDY inhibition. Besides these beneficial metabolic effects, INDY inhibition may also improve blood pressure control through sympathetic nervous system inhibition, partly via reduced peripheral catecholamine synthesis. These effects make INDY a promising candidate with bidirectional benefits for improving both metabolic disease and blood pressure control.

Item URL in elib:https://elib.dlr.de/189705/
Document Type:Article
Title:INDY as a Therapeutic Target for Cardio-Metabolic Disease
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Pesta, DominikInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0002-5089-3586
Jordan, JensInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Date:14 March 2022
Journal or Publication Title:Metabolites
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:12
DOI:10.3390/metabo12030244
Page Range:p. 244
Publisher:Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:2218-1989
Status:Published
Keywords:citrate transport; cardiovascular disease; metabolic disease; INDY (I’m Not Dead, Yet); SLC13A5; diabetes; insulin resistance; longevity; obesity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Pesta, Dominik
Deposited On:10 Nov 2022 11:33
Last Modified:21 Nov 2022 10:29

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