Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease

Pafili, Kalliopi and Kahl, Sabine and Strassburger, Klaus and Pesta, Dominik and Herder, Christian and Pützer, Jennifer and Dewidar, Bedair and Hendlinger, Mona and Granata, Cesare and Saatmann, Nina and Yavas, Aslihan and Gancheva, Sofiya and Heilmann, Geronimo and Esposito, Irene and Schlensak, Matthias and Roden, Michael (2022) Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease. Journal of Hepatology, 77 (6), pp. 1504-1514. Elsevier. doi: 10.1016/j.jhep.2022.08.010. ISSN 0168-8278.

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Official URL: https://www.sciencedirect.com/science/article/pii/S0168827822030100?via%3Dihub

Abstract

Adipose tissue (commonly called body fat) can be found under the skin (subcutaneous) or around internal organs (visceral). Dysfunction of adipose tissue can cause insulin resistance and lead to excess delivery of fat to other organs such as the liver. Herein, we show that dysfunction specifically in visceral adipose tissue was associated with fatty liver disease.

Item URL in elib:

https://elib.dlr.de/189701/

Document Type:

Article

Additional Information:

Online ahead of print. (In Press, Corrected Proof)

Title:

Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease

Authors:

Authors	Institution or Email of Authors	Author's ORCID iD	ORCID Put Code
Pafili, Kalliopi	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Kahl, Sabine	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Strassburger, Klaus	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Pesta, Dominik	Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany	https://orcid.org/0000-0002-5089-3586	UNSPECIFIED
Herder, Christian	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Pützer, Jennifer	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Dewidar, Bedair	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Hendlinger, Mona	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Granata, Cesare	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Saatmann, Nina	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Yavas, Aslihan	University Hospital and Heinrich-Heine-University	UNSPECIFIED	UNSPECIFIED
Gancheva, Sofiya	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Heilmann, Geronimo	Deutsches Diabetes-Zentrum	UNSPECIFIED	UNSPECIFIED
Esposito, Irene	University Hospital and Heinrich-Heine-University	UNSPECIFIED	UNSPECIFIED
Schlensak, Matthias	Department of General and Visceral Surgery, Neuwerk Hospital	UNSPECIFIED	UNSPECIFIED
Roden, Michael	German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany	https://orcid.org/0000-0001-8200-6382	UNSPECIFIED

Date:

19 August 2022

Journal or Publication Title:

Journal of Hepatology

Refereed publication:

Yes

Open Access:

Yes

Gold Open Access:

In SCOPUS:

Yes

In ISI Web of Science:

Yes

Volume:

DOI:

10.1016/j.jhep.2022.08.010

Page Range:

pp. 1504-1514

Publisher:

Elsevier

ISSN:

0168-8278

Status:

Published

Keywords:

hepatic steatosis; fat depots; energy metabolism; insulin-stimulated glucose disposal

HGF - Research field:

Aeronautics, Space and Transport

HGF - Program:

Space

HGF - Program Themes:

Research under Space Conditions

DLR - Research area:

Raumfahrt

DLR - Program:

R FR - Research under Space Conditions

DLR - Research theme (Project):

R - Muscle Mechanics and Metabolism

Location:

Köln-Porz

Institutes and Institutions:

Institute of Aerospace Medicine > Muscle and Bone Metabolism

Deposited By:

Pesta, Dominik

Deposited On:

10 Nov 2022 11:30

Last Modified:

14 Feb 2023 08:59

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