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Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease

Pafili, Kalliopi and Kahl, Sabine and Strassburger, Klaus and Pesta, Dominik and Herder, Christian and Pützer, Jennifer and Dewidar, Bedair and Hendlinger, Mona and Granata, Cesare and Saatmann, Nina and Yavas, Aslihan and Gancheva, Sofiya and Heilmann, Geronimo and Esposito, Irene and Schlensak, Matthias and Roden, Michael (2022) Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease. Journal of Hepatology, 77 (6), pp. 1504-1514. Elsevier. doi: 10.1016/j.jhep.2022.08.010. ISSN 0168-8278.

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Official URL: https://www.sciencedirect.com/science/article/pii/S0168827822030100?via%3Dihub


Adipose tissue (commonly called body fat) can be found under the skin (subcutaneous) or around internal organs (visceral). Dysfunction of adipose tissue can cause insulin resistance and lead to excess delivery of fat to other organs such as the liver. Herein, we show that dysfunction specifically in visceral adipose tissue was associated with fatty liver disease.

Item URL in elib:https://elib.dlr.de/189701/
Document Type:Article
Additional Information:Online ahead of print. (In Press, Corrected Proof)
Title:Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Pafili, KalliopiDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Kahl, SabineDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Strassburger, KlausDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Pesta, DominikInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0002-5089-3586UNSPECIFIED
Herder, ChristianDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Pützer, JenniferDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Dewidar, BedairDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Hendlinger, MonaDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Granata, CesareDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Saatmann, NinaDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Yavas, AslihanUniversity Hospital and Heinrich-Heine-UniversityUNSPECIFIEDUNSPECIFIED
Gancheva, SofiyaDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Heilmann, GeronimoDeutsches Diabetes-ZentrumUNSPECIFIEDUNSPECIFIED
Esposito, IreneUniversity Hospital and Heinrich-Heine-UniversityUNSPECIFIEDUNSPECIFIED
Schlensak, MatthiasDepartment of General and Visceral Surgery, Neuwerk HospitalUNSPECIFIEDUNSPECIFIED
Roden, MichaelGerman Center for Diabetes Research (DZD), Munich-Neuherberg, Germanyhttps://orcid.org/0000-0001-8200-6382UNSPECIFIED
Date:19 August 2022
Journal or Publication Title:Journal of Hepatology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:pp. 1504-1514
Keywords:hepatic steatosis; fat depots; energy metabolism; insulin-stimulated glucose disposal
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Pesta, Dominik
Deposited On:10 Nov 2022 11:30
Last Modified:14 Feb 2023 08:59

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