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Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease

Pafili, Kalliopi and Kahl, Sabine and Strassburger, Klaus and Pesta, Dominik and Herder, Christian and Pützer, Jennifer and Dewidar, Bedair and Hendlinger, Mona and Granata, Cesare and Saatmann, Nina and Yavas, Aslihan and Gancheva, Sofiya and Heilmann, Geronimo and Esposito, Irene and Schlensak, Matthias and Roden, Michael (2022) Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease. Journal of Hepatology, Online ahead of print. Elsevier. doi: 10.1016/j.jhep.2022.08.010. ISSN 0168-8278.

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Official URL: https://www.sciencedirect.com/science/article/pii/S0168827822030100?via%3Dihub

Abstract

Adipose tissue (commonly called body fat) can be found under the skin (subcutaneous) or around internal organs (visceral). Dysfunction of adipose tissue can cause insulin resistance and lead to excess delivery of fat to other organs such as the liver. Herein, we show that dysfunction specifically in visceral adipose tissue was associated with fatty liver disease.

Item URL in elib:https://elib.dlr.de/189701/
Document Type:Article
Additional Information:Online ahead of print. (In Press, Corrected Proof)
Title:Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Pafili, KalliopiDeutsches Diabetes-ZentrumUNSPECIFIED
Kahl, SabineDeutsches Diabetes-ZentrumUNSPECIFIED
Strassburger, KlausDeutsches Diabetes-ZentrumUNSPECIFIED
Pesta, DominikInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0002-5089-3586
Herder, ChristianDeutsches Diabetes-ZentrumUNSPECIFIED
Pützer, JenniferDeutsches Diabetes-ZentrumUNSPECIFIED
Dewidar, BedairDeutsches Diabetes-ZentrumUNSPECIFIED
Hendlinger, MonaDeutsches Diabetes-ZentrumUNSPECIFIED
Granata, CesareDeutsches Diabetes-ZentrumUNSPECIFIED
Saatmann, NinaDeutsches Diabetes-ZentrumUNSPECIFIED
Yavas, AslihanUniversity Hospital and Heinrich-Heine-UniversityUNSPECIFIED
Gancheva, SofiyaDeutsches Diabetes-ZentrumUNSPECIFIED
Heilmann, GeronimoDeutsches Diabetes-ZentrumUNSPECIFIED
Esposito, IreneUniversity Hospital and Heinrich-Heine-UniversityUNSPECIFIED
Schlensak, MatthiasDepartment of General and Visceral Surgery, Neuwerk HospitalUNSPECIFIED
Roden, MichaelGerman Center for Diabetes Research (DZD), Munich-Neuherberg, Germanyhttps://orcid.org/0000-0001-8200-6382
Date:19 August 2022
Journal or Publication Title:Journal of Hepatology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI:10.1016/j.jhep.2022.08.010
Page Range:Online ahead of print
Publisher:Elsevier
ISSN:0168-8278
Status:Published
Keywords:hepatic steatosis; fat depots; energy metabolism; insulin-stimulated glucose disposal
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Pesta, Dominik
Deposited On:10 Nov 2022 11:30
Last Modified:21 Nov 2022 10:30

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