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Roggan, Marie Denise and Kronenberg, Jessica and Wollert, Esther Katharina and Hoffmann, Sven and Pereira de Almeida, Paula and Nabawi, Yara and Nisar, Hasan and Konda, Bikash and Liemersdorf, Christian and Hemmersbach, Ruth and Hellweg, Christine E. (2022) Unraveling the role of glia cells in the space brain: Response of primary astrocytes to ionizing radiation exposure. jDeGBS Young Scientists Symposium, 28.– 30. September 2022, Kloster Schöntal, Schöntal, Germany.
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Abstract
Introduction: Exposure to space radiation is a major limiting factor for crewed space exploration. Astronauts encounter different types of space radiation (high-energy protons, He and heavy ions), which may cause a cognitive decline that manifests amongst others as learning difficulties, and also elevated anxiety and depression. Due to its limited regenerative potential, the central nervous system (CNS) is vulnerable towards radiation-induced damage. Astrocytes, the most abundant glial cells of the CNS, have different crucial functions in the CNS, e.g. maintaining normal brain function. In this work, the response of astrocytes towards low linear energy transfer (LET) X-rays and high-LET heavy ions was compared to unravel possible specific effects of space-relevant high-LET radiation.
| Item URL in elib: | https://elib.dlr.de/189203/ | ||||||||||||||||||||||||||||||||||||
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| Document Type: | Conference or Workshop Item (Speech) | ||||||||||||||||||||||||||||||||||||
| Title: | Unraveling the role of glia cells in the space brain: Response of primary astrocytes to ionizing radiation exposure | ||||||||||||||||||||||||||||||||||||
| Authors: |
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| Date: | September 2022 | ||||||||||||||||||||||||||||||||||||
| Refereed publication: | Yes | ||||||||||||||||||||||||||||||||||||
| Open Access: | No | ||||||||||||||||||||||||||||||||||||
| Gold Open Access: | No | ||||||||||||||||||||||||||||||||||||
| In SCOPUS: | No | ||||||||||||||||||||||||||||||||||||
| In ISI Web of Science: | No | ||||||||||||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||||||||||||
| Keywords: | ionizing radiation exposure, Astrocytes | ||||||||||||||||||||||||||||||||||||
| Event Title: | jDeGBS Young Scientists Symposium | ||||||||||||||||||||||||||||||||||||
| Event Location: | Kloster Schöntal, Schöntal, Germany | ||||||||||||||||||||||||||||||||||||
| Event Type: | international Conference | ||||||||||||||||||||||||||||||||||||
| Event Dates: | 28.– 30. September 2022 | ||||||||||||||||||||||||||||||||||||
| HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||||||||||||||
| HGF - Program: | Space | ||||||||||||||||||||||||||||||||||||
| HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||||||||||||||||||||||
| DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||||||||||||||
| DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||||||||||||||||||||||
| DLR - Research theme (Project): | R - NeuroSpace | ||||||||||||||||||||||||||||||||||||
| Location: | Köln-Porz | ||||||||||||||||||||||||||||||||||||
| Institutes and Institutions: | Institute of Aerospace Medicine > Radiation Biology Institute of Aerospace Medicine > Gravitational Biology Space Operations and Astronaut Training > User center for space experiments (MUSC) | ||||||||||||||||||||||||||||||||||||
| Deposited By: | Kopp, Kerstin | ||||||||||||||||||||||||||||||||||||
| Deposited On: | 10 Nov 2022 12:00 | ||||||||||||||||||||||||||||||||||||
| Last Modified: | 22 Nov 2022 14:15 |
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