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Unraveling the role of glia cells in the space brain: Response of primary astrocytes to ionizing radiation exposure

Roggan, Marie Denise and Kronenberg, Jessica and Wollert, Esther Katharina and Hoffmann, Sven and Pereira de Almeida, Paula and Nabawi, Yara and Nisar, Hasan and Konda, Bikash and Liemersdorf, Christian and Hemmersbach, Ruth and Hellweg, Christine E. (2022) Unraveling the role of glia cells in the space brain: Response of primary astrocytes to ionizing radiation exposure. jDeGBS Young Scientists Symposium, 28.– 30. September 2022, Kloster Schöntal, Schöntal, Germany.

Full text not available from this repository.

Abstract

Introduction: Exposure to space radiation is a major limiting factor for crewed space exploration. Astronauts encounter different types of space radiation (high-energy protons, He and heavy ions), which may cause a cognitive decline that manifests amongst others as learning difficulties, and also elevated anxiety and depression. Due to its limited regenerative potential, the central nervous system (CNS) is vulnerable towards radiation-induced damage. Astrocytes, the most abundant glial cells of the CNS, have different crucial functions in the CNS, e.g. maintaining normal brain function. In this work, the response of astrocytes towards low linear energy transfer (LET) X-rays and high-LET heavy ions was compared to unravel possible specific effects of space-relevant high-LET radiation.

Item URL in elib:https://elib.dlr.de/189203/
Document Type:Conference or Workshop Item (Speech)
Title:Unraveling the role of glia cells in the space brain: Response of primary astrocytes to ionizing radiation exposure
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Roggan, Marie DeniseRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Kronenberg, JessicaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; jessica.kronenberg (at) dlr.de and Microgravity User Support Center (MUSC), German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Wollert, Esther KatharinaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Current address: Forschungszentrum Jülich, Jülich, GermanyUNSPECIFIED
Hoffmann, SvenGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Gravitational Biology, CologneUNSPECIFIED
Pereira de Almeida, PaulaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Current address: Institute for Neuropathology, University Clinics Essen, GermanyUNSPECIFIED
Nabawi, YaraRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany;UNSPECIFIED
Nisar, HasanRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Lehtrar Road, Nilore, Islamabad, PakistanUNSPECIFIED
Konda, BikashRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; bikash.konda (at) dlr.deUNSPECIFIED
Liemersdorf, ChristianDepartment of Gravitational Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Hemmersbach, RuthGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne (Köln), Germany; Ruth.Hemmersbach (at) dlr.dehttps://orcid.org/0000-0001-5308-6715
Hellweg, Christine E.Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, Linder Hoehe, 51147 Cologne (Köln), Germany; Christine.Hellweg (at) dlr.dehttps://orcid.org/0000-0002-2223-3580
Date:September 2022
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:ionizing radiation exposure, Astrocytes
Event Title:jDeGBS Young Scientists Symposium
Event Location:Kloster Schöntal, Schöntal, Germany
Event Type:international Conference
Event Dates:28.– 30. September 2022
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - NeuroSpace
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Institute of Aerospace Medicine > Gravitational Biology
Space Operations and Astronaut Training > User center for space experiments (MUSC)
Deposited By: Kopp, Kerstin
Deposited On:10 Nov 2022 12:00
Last Modified:22 Nov 2022 14:15

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