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DNA Repair in Human Lymphocytes after Radiation Exposure under Mild Hypoxia

Schmitt, Lena-Marie (2022) DNA Repair in Human Lymphocytes after Radiation Exposure under Mild Hypoxia. Bachelor's, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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During space flights and long-term space missions, astronauts are exposed to elevated doses of radiation posing a significant health risk. Ionizing radiation induces DNA damage and accompanying cellular responses in all human tissues and can have deleterious effects on the whole organism including cell death or tumor development. To realize plans like setting up a lunar basecamp or even flying to Mars, individual radiation risks coming up during long-term stays in space must be elucidated and countermeasures must be identified and evaluated. Since the basic mechanisms that are induced by exposure to increased radiation doses and underlie the radiation-associated health risks are similar amongst astronauts during space flights and patients receiving radiotherapy, findings from research under space conditions could furthermore be derived for clinical applications, such as the prevention of radiation toxicity for radiotherapy patients. Being able to investigate individual responses to such therapies or modifying these responses in healthy or tumor tissue would be a major improvement for cancer patients und an enormous advance for cancer therapy in general. [...]

Item URL in elib:https://elib.dlr.de/188583/
Document Type:Thesis (Bachelor's)
Title:DNA Repair in Human Lymphocytes after Radiation Exposure under Mild Hypoxia
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Schmitt, Lena-MarieRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Date:September 2022
Refereed publication:Yes
Open Access:No
Number of Pages:113
Keywords:Hypoxia, space flights, radiation risks, DNA repair
Institution:Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany
Department:Faculty of Mathematics and Natural Sciences
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Radiation & Hypoxia
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:09 Jan 2023 14:38
Last Modified:09 Jan 2023 14:38

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