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Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods

Möstl, S. and Hoffmann, F. and Hönemann, J. and Alvero-Cruz, J.R. and Rittweger, J. and Tank, J. and Jordan, J. (2022) Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods. eLife, 11, e73428. eLife Sciences Publications. doi: 10.7554/eLife.73428. ISSN 2050-084X.

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Official URL: http://www.doi.org/10.7554/eLife.73428

Abstract

Background: Pulse wave velocity (PWV) independently predicts cardiovascular risk. Easy to use single-cuff oscillometric methods are utilized in clinical practice to estimate PWV. We applied the approach in master athletes to assess possible beneficial effects of lifelong exercise on vascular health. Furthermore, we compared single-cuff measurements with a two-cuff method in another cohort. Methods: We obtained single-cuff upper arm oscillometric measurements thrice in 129 master athletes aged 35–86 years and estimated PWV using the ArcSolver algorithm. We applied the same method in 24 healthy persons aged 24–55 years participating in a head down tilt bedrest study. In the latter group, we also obtained direct PWV measurements using a thigh cuff. Results: Estimated pulse velocity very highly correlated with age (R2 = 0.90) in master athletes. Estimated PWV values were located on the same regression line like values obtained in participants of the head down tilt bed rest study. The modest correlation between estimated and measured PWV (R² 0.40; p<0.05) was attenuated after adjusting for age; the mean difference between PWV measurements was 1 m/s. Conclusions: Estimated PWV mainly reflects the entered age rather than true vascular properties and, therefore, failed detecting beneficial effects of lifelong exercise.

Item URL in elib:https://elib.dlr.de/188221/
Document Type:Article
Title:Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Möstl, S.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Hönemann, J.Univ of Cologne and German Aerospace Cntr, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Alvero-Cruz, J.R.Facultad de Medicina, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Málaga, SpainUNSPECIFIED
Rittweger, J.Muscle and Bone Metabolism Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Joern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Tank, J.German Aerospace Center, Institute of Aerospace Medicinehttps://orcid.org/0000-0002-5672-1187
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Date:3 May 2022
Journal or Publication Title:eLife
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:11
DOI:10.7554/eLife.73428
Page Range:e73428
Publisher:eLife Sciences Publications
ISSN:2050-084X
Status:Published
Keywords:aging; hemodynamics; human; hypertension-mediated organ damage; medicine; prevention; pulse wave velocity.
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Kaiser-Stolz, Claudia
Deposited On:22 Sep 2022 09:42
Last Modified:04 Oct 2022 11:49

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