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Functional Cardiac Adaptation to 60 Days Strict Head-Down-Tilt Bedrest

Hoffmann, F. and Rabineau, J. and Mehrkens, D. and Johannes, B. and Caiania, E.G. and Migeotte, P.-F. and Jordan, J and Tank, Jens (2020) Functional Cardiac Adaptation to 60 Days Strict Head-Down-Tilt Bedrest. Circulation, p. 15153. Lippincott, Williams & Wilkins. doi: 10.1161/circ.142.suppl_3.15153. ISSN 0009-7322.

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Official URL: https://www.ahajournals.org/doi/10.1161/circ.142.suppl_3.15153


Background: Reduced physical activity increases the risk for heart failure. Myocardial strain measurements capture subtle abnormalities in myocardial function. We tested the hypothesis that bedrest deconditioning produces cardiac dysfunction in healthy persons. Methods: In the AGBRESA study, which assessed artificial gravity through centrifugation as potential countermeasure for space travel, 24 healthy persons (8 women) were submitted to 60 days strict -6°-head-down-tilt bedrest. 8 subjects each were included in a control group or groups subjected to continuous artificial gravity training on a short-arm centrifuge [30 minutes/day] or intermittent centrifugation [6x5 min/day]. We assessed cardiac morphology, function, strain and hemodynamics by cardiac-MRI (baseline, end of bedrest, recovery) and echocardiography (baseline, end of bedrest). Before and after bedrest, we assessed orthostatic heart rate responses as measure of cardiovascular deconditioning. Results: We conducted a pooled analysis because cardiovascular responses to bedrest did not differ between groups. Supine heart rate (baseline: 64±9.6bpm; bedrest: 72.3±10.5bpm; recovery: 69.6±10.5bpm, p<0.0001) and diastolic blood-pressure (69.6±7.3mmHg; bedrest: 78.5±6.9mmHg; recovery: 70.3±6.3mmHg, p<0.0001) increased with bedrest. With head-up tilt, heart rate increased 22.8±10.5bpm before and 45.9±213bpm at the end of bedrest (p<0.0001) consistent with cardiovascular deconditioning. Cardiac-output decreased from 6.6±0.9l/min to 6±1l/min at end of bedrest (recovery: 6.8±1.2l/min, p=0.0096). Left ventricular ejection fraction and mass-index did not change. Echocardiographic global longitudinal strain (baseline: -19.90±2.1%; bedrest: -18.1±2.1%, p<0.0001) decreased, whereas global circumferential strain in MRI tended to increase (baseline: -18.6±1.7%; bedrest: -19.1±1.6%, p=0.0843). After four days of recovery MRI measurements had returned to baseline. Conclusion: In healthy persons, cardiovascular deconditioning through 60 days head-down-tilt bedrest does not lead to cardiac atrophy or sustained reductions in cardiac performance. The transient nature of cardiac strain changes suggests functional rather than structural changes in the heart.

Item URL in elib:https://elib.dlr.de/186776/
Document Type:Article
Title:Functional Cardiac Adaptation to 60 Days Strict Head-Down-Tilt Bedrest
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Rabineau, J.LPHYS, Université Libre de Bruxelles, Brussels, BelgiumUNSPECIFIEDUNSPECIFIED
Mehrkens, D.Department of Internal Medicine III, University of Cologne, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Johannes, B.Department of Muscle and Bone Metabolism, German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Caiania, E.G.Politecnico di Milano, Milan, ItalyUNSPECIFIEDUNSPECIFIED
Migeotte, P.-F.Université libre de Bruxelles (ULB), Brussels, BelgiumUNSPECIFIEDUNSPECIFIED
Jordan, JUNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Tank, JensUNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Date:12 November 2020
Journal or Publication Title:Circulation
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:p. 15153
Publisher:Lippincott, Williams & Wilkins
Keywords:Functional Cardiac Adaption; Head Down Tilt Bedrest; Cardiac dsyfunction
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:30 Jun 2022 13:59
Last Modified:30 Jun 2022 13:59

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