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Short-term Response of Serum Cartilage Oligomeric Matrix Protein to Different Types of Impact Loading Under Normal and Artificial Gravity

Dreiner, Maren and Willwacher, Steffen and Kramer, Andreas and Kümmel, Jakob and Frett, Timo and Zaucke, Frank and Liphardt, Anna-Maria and Gruber, Markus and Niehoff, Anja (2020) Short-term Response of Serum Cartilage Oligomeric Matrix Protein to Different Types of Impact Loading Under Normal and Artificial Gravity. Frontiers in Physiology, 11 (1032). Frontiers Media S.A. doi: 10.3389/fphys.2020.01032. ISSN 1664-042X.

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Abstract

Microgravity during long-term space flights induces degeneration of articular cartilage. Artificial gravity through centrifugation combined with exercise has been suggested as a potential countermeasure for musculoskeletal degeneration. The purpose of this study was to investigate the effect of different types of impact loading under normal and artificial gravity conditions on serum concentrations of cartilage oligomeric matrix protein (COMP), a biomarker of cartilage metabolism. Fifteen healthy male adults (26 ± 4 years, 181 ± 4 cm, 77 ± 6 kg) performed four different 30-min impact loading protocols on four experimental days: jumping with artificial gravity elicited by centrifugation in a short-arm centrifuge (AGJ), jumping with artificial gravity generated by low-pressure cylinders in a sledge jump system (SJS), vertical jumping under Earth gravity (EGJ), and running under Earth gravity (RUN). Five blood samples per protocol were taken: 30 min before, immediately before, immediately after, 30 min after, and 60 min after impact loading. Serum COMP concentrations were analyzed in these samples. During the impact exercises, ground reaction forces were recorded. Peak ground reaction forces were significantly different between the three jumping protocols (p < 0.001), increasing from AGJ (14 N/kg) to SJS (22 N/kg) to EGJ (29 N/kg) but were similar in RUN (22 N/kg) compared to SJS. The serum COMP concentration was increased (p < 0.001) immediately after all loading protocols, and then decreased (p < 0.001) at 30 min post-exercise compared to immediately after the exercise. Jumping and running under Earth gravity (EGJ and RUN) resulted in a significantly higher (p < 0.05) increase of serum COMP levels 30 min after impact loading compared to the impact loading under artificial gravity (RUN +30%, EGJ +20%, AGJ +17%, and SJS +13% compared to baseline). In conclusion, both the amplitude and the number of the impacts contribute to inducing higher COMP responses and are therefore likely important factors affecting cartilage metabolism. RUN had the largest effect on serum COMP concentration, presumably due to the high number of impacts, which was 10 times higher than for the jump modalities. Future studies should aim at establishing a dose-response relationship for different types of exercise using comparable amounts of impacts.

Item URL in elib:https://elib.dlr.de/185772/
Document Type:Article
Title:Short-term Response of Serum Cartilage Oligomeric Matrix Protein to Different Types of Impact Loading Under Normal and Artificial Gravity
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Dreiner, MarenInstitute of Biomechanics and Orthopaedics, German Sport University Cologne, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Willwacher, SteffenInstitute of Biomechanics and Orthopaedics, German Sport University Cologne, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Kramer, AndreasNeuromechanics Research Group, Sport Sciences, University of Konstanz, Konstanz, GermanyUNSPECIFIEDUNSPECIFIED
Kümmel, JakobUniversity of KonstanzUNSPECIFIEDUNSPECIFIED
Frett, TimoUNSPECIFIEDhttps://orcid.org/0000-0002-5572-1177UNSPECIFIED
Zaucke, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liphardt, Anna-MariaDeutsche Sporthochschule KölnUNSPECIFIEDUNSPECIFIED
Gruber, MarkusDepartment of Sport Science, University of Konstanz, Konstanz, Germanyhttps://orcid.org/0000-0002-0233-3912UNSPECIFIED
Niehoff, AnjaGerman Sport University CologneUNSPECIFIEDUNSPECIFIED
Date:31 August 2020
Journal or Publication Title:Frontiers in Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:11
DOI:10.3389/fphys.2020.01032
Publisher:Frontiers Media S.A
ISSN:1664-042X
Status:Published
Keywords:articular cartilage; artificial gravity; cartilage oligomeric matrix protein; centrifuge; countermeasure; impact loading; reactive jumping
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Human performance under altered gravity conditions
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Becker, Christine
Deposited On:11 Apr 2022 10:20
Last Modified:25 May 2022 09:10

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