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The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model

Grimm, Daniela and Schulz, Herbert and Krüger, Marcus and Cortés-Sánchez, José Luis and Egli, Marcel and Kraus, Armin and Sahana, Jayashree and Corydon, Thoma J. and Hemmersbach, Ruth and Wise, Petra and Infanger, Manfred and Wehland, Markus (2022) The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model. International Journal of Molecular Sciences, 23 (6), p. 3073. Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390/ijms23063073. ISSN 1661-6596.

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Official URL: https://www.mdpi.com/1422-0067/23/6/3073

Abstract

Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality. Therefore, groundbreaking research and innovations are necessary. Research in space under microgravity (µg) conditions is a novel approach with the potential to fight cancer and develop future cancer therapies. Space travel is accompanied by adverse effects on our health, and there is a need to counteract these health problems. On the cellular level, studies have shown that real (r-) and simulated (s-) µg impact survival, apoptosis, proliferation, migration, and adhesion as well as the cytoskeleton, the extracellular matrix, focal adhesion, and growth factors in cancer cells. Moreover, the µg-environment induces in vitro 3D tumor models (multicellular spheroids and organoids) with a high potential for preclinical drug targeting, cancer drug development, and studying the processes of cancer progression and metastasis on a molecular level. This review focuses on the effects of r- and s-µg on different types of cells deriving from thyroid, breast, lung, skin, and prostate cancer, as well as tumors of the gastrointestinal tract. In addition, we summarize the current knowledge of the impact of µg on cancerous stem cells. The information demonstrates that µg has become an important new technology for increasing current knowledge of cancer biology.

Item URL in elib:https://elib.dlr.de/185751/
Document Type:Article
Title:The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Grimm, DanielaOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, Germany and Aarhus University, Department of Biomedicine, Aarhus, Denmarkhttps://orcid.org/0000-0002-5083-2812UNSPECIFIED
Schulz, HerbertUniversity Hospital Magdeburg, Otto von Guericke University, Department of Microgravity and Translational Regenerative Medicine, Medical Faculty,UNSPECIFIEDUNSPECIFIED
Krüger, MarcusOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, Germanyhttps://orcid.org/0000-0003-1120-0246UNSPECIFIED
Cortés-Sánchez, José LuisOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, Germanyhttps://orcid.org/0000-0002-4646-9520UNSPECIFIED
Egli, MarcelLucerne University of Applied Sciences and Arts,Space Biology Group, Institute of Medical Engineering,UNSPECIFIEDUNSPECIFIED
Kraus, ArminUniversity Hospital Magdeburg, Otto von Guericke University, Department of Microgravity and Translational Regenerative Medicine, Medical FacultyUNSPECIFIEDUNSPECIFIED
Sahana, JayashreeUniversity Aarhus, Department of Biomedicine and Pharmacology, Aarhus, Denmarkhttps://orcid.org/0000-0002-6606-6315UNSPECIFIED
Corydon, Thoma J.Aarhus University, Department of Biomedicine, Aarhus, Denmarkhttps://orcid.org/0000-0003-3588-6350UNSPECIFIED
Hemmersbach, RuthGerman Aerospace Center (DLR e.V.), Institute of Aerospace Medicine, Gravitational Biology, Cologne (Köln), Germanyhttps://orcid.org/0000-0001-5308-6715UNSPECIFIED
Wise, PetraUniversity of Southern California, The Saban Research Institute, Children’s Hospital Los Angeles,UNSPECIFIEDUNSPECIFIED
Infanger, ManfredOtto-von-Guericke-University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, GermanyUNSPECIFIEDUNSPECIFIED
Wehland, MarkusOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Department of Microgravity & Translational Regenerative Medicine, Magdeburg, Germanyhttps://orcid.org/0000-0002-8160-859XUNSPECIFIED
Date:12 March 2022
Journal or Publication Title:International Journal of Molecular Sciences
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:23
DOI:10.3390/ijms23063073
Page Range:p. 3073
Editors:
EditorsEmailEditor's ORCID iDORCID Put Code
UNSPECIFIEDMDPIUNSPECIFIEDUNSPECIFIED
Publisher:Multidisciplinary Digital Publishing Institute (MDPI)
Series Name:Int. J. Mol. Sci.
ISSN:1661-6596
Status:Published
Keywords:cancer stem cells, thyroid cancer, breast cancer, prostate cancer, liver cancer, colorectal cancer, microgravity, multicellular spheroids, organoids, clinostate, random positioning machine, rotating wall vessel, spaceflight, omics studies,
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Gravisensorics
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Chiodo, Annette
Deposited On:11 Apr 2022 10:19
Last Modified:13 Oct 2022 12:52

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