Lau, Patrick and Beijer, Asa and Rosenberger, Andre and Zange, Jochen and Rittweger, Jörn (2018) Resistive exercise with or without super-imposed whole-body vibration acutely effects bone turnover. In: FASEB JOURNAL, 32 (1), 855.20-855.20. Federation of American Societies for Experimental Biology (FASEB). Experimental Biology Conference, 2018-04-21 - 2018-04-25, San Diego, USA. doi: 10.1096/fasebj.2018.32.1_supplement.855.20.
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Official URL: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.2018.32.1_supplement.855.20
Abstract
[Background] Exercise is one of the well-known constituents to improve bone mass and to retain bone strength. Only few studies have reached the effects of resistive exercise on sclerostin levels, a protein that is thought to play a key role in orchestrating bone’s mechanical adaptation. Sclerostin is produced and released by osteocytes and acts as an inhibitor of bone formation through inhibition of the Wnt/β-catenin-signaling pathway. The objective of this study was to evaluate acute and long-term effects of exercise on bone biochemical marker expression. More specifically, we aimed to understand differences in the responses to resistance exercise with or without whole-body vibration. [Methods] A six week training intervention was performed including 26 healthy males (26 years, SD=4) in in a randomized parallel design. Performing either resistive exercise (RE, n=13) or resistive vibration exercise (RVE, n=13) training, with weekly increasing vibration frequencies 20-40 Hz. Serum samples were collected both at the initial and final exercise session. Changes in carboxy-terminal cross-linked telopeptide of type I collagen (sCTX-I), as a marker of bone resorption, and of procollagen type I amino terminal propeptide (P1NP) as a specific marker of bone formation as well as serum sclerostin concentrations were measured via ELISA (sCTX-I and sclerostin) or RIA (P1NP) measurements. [Results] Serum markers of sCTX-I decreased by 15% within the first minutes following either training intervention, both regarding the initial and final training session. Subsequently, levels of sCTX-I returned back to pre-bout baseline after RE (time effect: P<0.001), and they depicted an overshoot by 18% after 75min. Serum levels of P1NP depicted an acute increase by 15% to exercise (P<0.001). P1NP levels were non-substantially increased in RE at the end of the 6 week intervention (P<0.001), but decreased by 10% in RVE, as compared to baseline (P< 0.001). Pre-bout levels of sclerostin were marginally lowered at the end of the 6 week training phase. After the exercise bouts, sclerostin levels increased within the first minutes both RE and RVE (time effect: P<0.001). Notably, sclerostin responses to the initial exercise bouts differed significantly between RE and RVE P=0.029. [Conclusion] The present findings suggest that in young healthy adults both conditions RE and RVE elicited an acute exercise-induced bone resorption without any acute change in bone formation. Results are compatible with the idea that this response was mediated by sclerostin
Item URL in elib: | https://elib.dlr.de/185693/ | ||||||||||||||||||||||||
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Document Type: | Conference or Workshop Item (Poster) | ||||||||||||||||||||||||
Title: | Resistive exercise with or without super-imposed whole-body vibration acutely effects bone turnover | ||||||||||||||||||||||||
Authors: |
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Date: | April 2018 | ||||||||||||||||||||||||
Journal or Publication Title: | FASEB JOURNAL | ||||||||||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||||||||||
Open Access: | Yes | ||||||||||||||||||||||||
Gold Open Access: | No | ||||||||||||||||||||||||
In SCOPUS: | No | ||||||||||||||||||||||||
In ISI Web of Science: | Yes | ||||||||||||||||||||||||
Volume: | 32 | ||||||||||||||||||||||||
DOI: | 10.1096/fasebj.2018.32.1_supplement.855.20 | ||||||||||||||||||||||||
Page Range: | 855.20-855.20 | ||||||||||||||||||||||||
Editors: |
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Publisher: | Federation of American Societies for Experimental Biology (FASEB) | ||||||||||||||||||||||||
Status: | Published | ||||||||||||||||||||||||
Keywords: | resistive exercise, resistive vibration exercise, sclerostin, osteokine, sCTX, P1NP | ||||||||||||||||||||||||
Event Title: | Experimental Biology Conference | ||||||||||||||||||||||||
Event Location: | San Diego, USA | ||||||||||||||||||||||||
Event Type: | international Conference | ||||||||||||||||||||||||
Event Start Date: | 21 April 2018 | ||||||||||||||||||||||||
Event End Date: | 25 April 2018 | ||||||||||||||||||||||||
Organizer: | Scintica Instrumentation Inc | ||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||
HGF - Program: | Space | ||||||||||||||||||||||||
HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||||||||||
DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||
DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||||||||||
DLR - Research theme (Project): | R - Muscle Mechanics and Metabolism | ||||||||||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine > Muscle and Bone Metabolism | ||||||||||||||||||||||||
Deposited By: | Becker, Christine | ||||||||||||||||||||||||
Deposited On: | 11 Apr 2022 09:51 | ||||||||||||||||||||||||
Last Modified: | 24 Apr 2024 20:47 |
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