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Resistive exercise with or without super-imposed whole-body vibration acutely effects bone turnover

Lau, Patrick und Beijer, Asa und Rosenberger, Andre und Zange, Jochen und Rittweger, Jörn (2018) Resistive exercise with or without super-imposed whole-body vibration acutely effects bone turnover. In: FASEB JOURNAL, 32 (1), 855.20-855.20. Federation of American Societies for Experimental Biology (FASEB). Experimental Biology Conference, Apr. 21-25, 2018, San Diego, USA. doi: 10.1096/fasebj.2018.32.1_supplement.855.20.

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Offizielle URL: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.2018.32.1_supplement.855.20

Kurzfassung

[Background] Exercise is one of the well-known constituents to improve bone mass and to retain bone strength. Only few studies have reached the effects of resistive exercise on sclerostin levels, a protein that is thought to play a key role in orchestrating bone’s mechanical adaptation. Sclerostin is produced and released by osteocytes and acts as an inhibitor of bone formation through inhibition of the Wnt/β-catenin-signaling pathway. The objective of this study was to evaluate acute and long-term effects of exercise on bone biochemical marker expression. More specifically, we aimed to understand differences in the responses to resistance exercise with or without whole-body vibration. [Methods] A six week training intervention was performed including 26 healthy males (26 years, SD=4) in in a randomized parallel design. Performing either resistive exercise (RE, n=13) or resistive vibration exercise (RVE, n=13) training, with weekly increasing vibration frequencies 20-40 Hz. Serum samples were collected both at the initial and final exercise session. Changes in carboxy-terminal cross-linked telopeptide of type I collagen (sCTX-I), as a marker of bone resorption, and of procollagen type I amino terminal propeptide (P1NP) as a specific marker of bone formation as well as serum sclerostin concentrations were measured via ELISA (sCTX-I and sclerostin) or RIA (P1NP) measurements. [Results] Serum markers of sCTX-I decreased by 15% within the first minutes following either training intervention, both regarding the initial and final training session. Subsequently, levels of sCTX-I returned back to pre-bout baseline after RE (time effect: P<0.001), and they depicted an overshoot by 18% after 75min. Serum levels of P1NP depicted an acute increase by 15% to exercise (P<0.001). P1NP levels were non-substantially increased in RE at the end of the 6 week intervention (P<0.001), but decreased by 10% in RVE, as compared to baseline (P< 0.001). Pre-bout levels of sclerostin were marginally lowered at the end of the 6 week training phase. After the exercise bouts, sclerostin levels increased within the first minutes both RE and RVE (time effect: P<0.001). Notably, sclerostin responses to the initial exercise bouts differed significantly between RE and RVE P=0.029. [Conclusion] The present findings suggest that in young healthy adults both conditions RE and RVE elicited an acute exercise-induced bone resorption without any acute change in bone formation. Results are compatible with the idea that this response was mediated by sclerostin

elib-URL des Eintrags:https://elib.dlr.de/185693/
Dokumentart:Konferenzbeitrag (Poster)
Titel:Resistive exercise with or without super-imposed whole-body vibration acutely effects bone turnover
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Lau, PatrickPatrick.Lau (at) dlr.dehttps://orcid.org/0000-0002-7290-5875NICHT SPEZIFIZIERT
Beijer, AsaGerman Aerospace Center, Institute of Aerospace Medicine and Space Physiology, Cologne, Germany; asa.beijer (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Rosenberger, AndreAndre.Rosenberger (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952133724726
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963NICHT SPEZIFIZIERT
Datum:April 2018
Erschienen in:FASEB JOURNAL
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Ja
Band:32
DOI:10.1096/fasebj.2018.32.1_supplement.855.20
Seitenbereich:855.20-855.20
Herausgeber:
HerausgeberInstitution und/oder E-Mail-Adresse der HerausgeberHerausgeber-ORCID-iDORCID Put Code
Pederson, ThoruNICHT SPEZIFIZIERTNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Verlag:Federation of American Societies for Experimental Biology (FASEB)
Status:veröffentlicht
Stichwörter:resistive exercise, resistive vibration exercise, sclerostin, osteokine, sCTX, P1NP
Veranstaltungstitel:Experimental Biology Conference
Veranstaltungsort:San Diego, USA
Veranstaltungsart:internationale Konferenz
Veranstaltungsdatum:Apr. 21-25, 2018
Veranstalter :Scintica Instrumentation Inc
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Muskelmechanik und Metabolismus
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Muskel- und Knochenstoffwechsel
Hinterlegt von: Becker, Christine
Hinterlegt am:11 Apr 2022 09:51
Letzte Änderung:25 Apr 2023 12:18

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