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Resistive exercise with or without super-imposed whole-body vibration acutely effects bone turnover

Lau, Patrick and Beijer, Asa and Rosenberger, Andre and Zange, Jochen and Rittweger, Jörn (2018) Resistive exercise with or without super-imposed whole-body vibration acutely effects bone turnover. In: FASEB JOURNAL, 32 (1), 855.20-855.20. Federation of American Societies for Experimental Biology (FASEB). Experimental Biology Conference, Apr. 21-25, 2018, San Diego, USA. doi: 10.1096/fasebj.2018.32.1_supplement.855.20.

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Official URL: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.2018.32.1_supplement.855.20

Abstract

[Background] Exercise is one of the well-known constituents to improve bone mass and to retain bone strength. Only few studies have reached the effects of resistive exercise on sclerostin levels, a protein that is thought to play a key role in orchestrating bone’s mechanical adaptation. Sclerostin is produced and released by osteocytes and acts as an inhibitor of bone formation through inhibition of the Wnt/β-catenin-signaling pathway. The objective of this study was to evaluate acute and long-term effects of exercise on bone biochemical marker expression. More specifically, we aimed to understand differences in the responses to resistance exercise with or without whole-body vibration. [Methods] A six week training intervention was performed including 26 healthy males (26 years, SD=4) in in a randomized parallel design. Performing either resistive exercise (RE, n=13) or resistive vibration exercise (RVE, n=13) training, with weekly increasing vibration frequencies 20-40 Hz. Serum samples were collected both at the initial and final exercise session. Changes in carboxy-terminal cross-linked telopeptide of type I collagen (sCTX-I), as a marker of bone resorption, and of procollagen type I amino terminal propeptide (P1NP) as a specific marker of bone formation as well as serum sclerostin concentrations were measured via ELISA (sCTX-I and sclerostin) or RIA (P1NP) measurements. [Results] Serum markers of sCTX-I decreased by 15% within the first minutes following either training intervention, both regarding the initial and final training session. Subsequently, levels of sCTX-I returned back to pre-bout baseline after RE (time effect: P<0.001), and they depicted an overshoot by 18% after 75min. Serum levels of P1NP depicted an acute increase by 15% to exercise (P<0.001). P1NP levels were non-substantially increased in RE at the end of the 6 week intervention (P<0.001), but decreased by 10% in RVE, as compared to baseline (P< 0.001). Pre-bout levels of sclerostin were marginally lowered at the end of the 6 week training phase. After the exercise bouts, sclerostin levels increased within the first minutes both RE and RVE (time effect: P<0.001). Notably, sclerostin responses to the initial exercise bouts differed significantly between RE and RVE P=0.029. [Conclusion] The present findings suggest that in young healthy adults both conditions RE and RVE elicited an acute exercise-induced bone resorption without any acute change in bone formation. Results are compatible with the idea that this response was mediated by sclerostin

Item URL in elib:https://elib.dlr.de/185693/
Document Type:Conference or Workshop Item (Poster)
Title:Resistive exercise with or without super-imposed whole-body vibration acutely effects bone turnover
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Lau, PatrickPatrick.Lau (at) dlr.dehttps://orcid.org/0000-0002-7290-5875
Beijer, AsaGerman Aerospace Center, Institute of Aerospace Medicine and Space Physiology, Cologne, Germany; asa.beijer (at) dlr.deUNSPECIFIED
Rosenberger, AndreAndre.Rosenberger (at) dlr.deUNSPECIFIED
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Date:April 2018
Journal or Publication Title:FASEB JOURNAL
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:32
DOI:10.1096/fasebj.2018.32.1_supplement.855.20
Page Range:855.20-855.20
Editors:
EditorsEmailEditor's ORCID iD
Pederson, ThoruUNSPECIFIEDUNSPECIFIED
Publisher:Federation of American Societies for Experimental Biology (FASEB)
Status:Published
Keywords:resistive exercise, resistive vibration exercise, sclerostin, osteokine, sCTX, P1NP
Event Title:Experimental Biology Conference
Event Location:San Diego, USA
Event Type:international Conference
Event Dates:Apr. 21-25, 2018
Organizer:Scintica Instrumentation Inc
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:11 Apr 2022 09:51
Last Modified:14 Apr 2022 11:48

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