elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Sympathetic neural traffic in older patients with type 2 diabetes mellitus

Heusser, K. and Tank, J. and Johannes, B. and Jordan, J (2019) Sympathetic neural traffic in older patients with type 2 diabetes mellitus. 30th International Symposium on the Autonomic Nervous System, 06.-09.11. Nov. 2019, Florida.

Full text not available from this repository.

Abstract

Introduction: Mechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. The finding raised interest in interventions targeting the sympathetic nervous system. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk. However, data on sympathetic activity in this population is scarce. Material and Methods: We recruited patients with type 2 diabetes mellitus for at least 2 years, an age of 50-80 years, an HbA1c of 6.5-10.0%, and a BMI of 25-40 kg/m2. They had to be treated with stable doses of metformin only. In the supine position, we recorded ECG, brachial blood pressure, and muscle sympathetic nerve activity (MSNA). We quantified MSNA as burst frequency, burst incidence, and burst area. Results: We included 37 patients (14 women, 63±1 years, 32.8±0.8 kg/m2; 23 men, 64±1 years, 30.3±0.7 kg/m2). Blood pressure was 127±4/74±3 mmHg in women and 126±3/77±2 mmHg in men (p=0.92/0.42). Heart rate was 68±3 bpm in women and 62±1 bpm in men (p=0.03). Overall, MSNA ranged between 15 and 72 bursts/min. MSNA was 39.5±3.5 bursts/min in women and 38.5±2.3 bpm in men (p=0.80). Similarly, MSNA burst incidence and burst area did not differ between women and men. In the pooled analysis, MSNA was not correlated with systolic blood pressure, diastolic blood pressure, body mass index, or HbA1c (r2 0.30 for all). Conclusions: In older patients with type 2 diabetes mellitus, MSNA appears to be not or only weakly related to gender, blood pressure, body mass index, or glycemic control. The findings suggest that sympathetic contributions to blood pressure and glucose metabolism are highly variable in this population, which may have implications for therapeutic interventions targeting the sympathetic nervous system.

Item URL in elib:https://elib.dlr.de/185685/
Document Type:Conference or Workshop Item (Poster)
Title:Sympathetic neural traffic in older patients with type 2 diabetes mellitus
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany; Karsten.Heusser (at) dlr.dehttps://orcid.org/0000-0002-2571-5585
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Johannes, B.UNSPECIFIEDUNSPECIFIED
Jordan, JInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Date:2019
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:type 2 diabetes mellitus; sympathetic neural traffic
Event Title:30th International Symposium on the Autonomic Nervous System
Event Location:Florida
Event Type:international Conference
Event Dates:06.-09.11. Nov. 2019
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:08 Apr 2022 13:38
Last Modified:08 Apr 2022 13:38

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.