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AORTIC VESSEL WALL PROPERTIES DURING 60 DAYS STRICT HEAD DOWN TILT BEDREST - PRELIMINARY RESULTS OF AGBRESA

Moestl, S. and Rabineau, J. and Hoffmann, F. and Caiani, E.G. and Migeotte, P.-F. and Bachler, M. and Hametner, B. and Wassertheurer, S. and Jordan, J and Tank, Jens (2020) AORTIC VESSEL WALL PROPERTIES DURING 60 DAYS STRICT HEAD DOWN TILT BEDREST - PRELIMINARY RESULTS OF AGBRESA. NASA Human Research Program Investigators' Workshop, 27.01.2020, Galveston.

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Abstract

Background Changes in large artery properties including increased arterial compliance and increased carotid artery stiffness have been described after space flight. Altered vascular structure, which heralds cardiovascular risk, and reversible changes in vascular function could contribute to the response. Compared with previous studies, which did not reproduce these findings, AGBRESA applied strict -6° head-down bedrest (HDT) mimicking chronic cephalad fluid shifts in space. In this study, we assessed aortic vessel wall properties using state-of-the art imaging methods and pulse wave analysis and tested for possible protective effects of artificial gravity training. Material and Methods We present preliminary data from 12 healthy subjects (8 men, 4 women) obtained during baseline data collection 9-6 days before bedrest (BDC, supine position) and towards the end of two months head down tilt bedrest (MRI on day 56 and echocardiography on day 60 of HDT). Subjects were assigned to 30 minutes per day continuous short arm centrifugation (cAG), 6 times for 5 minutes interval short arm centrifugation, iAG), or a control group (ctr). We assessed aortic pulse wave velocity using oscillometric upper arm and thigh cuffs (PWV-2C, CardioCube, AIT, Vienna, Austria) and 4D-flow cardiac velocity encoded phase contrast magnetic resonance imaging (PWV-4D-MRI). We also measured area, area changes, and distensibility (AoD) of the ascending aorta by 2D-phase contrast cardiac MRI and arterial compliance (Ca) using transthoracic echocardiography. Results Mean aortic area increased in all subjects after 60 days head down tilt bedrest (5.3±0.7 vs. 5.8±0.7 cm², p<0.05). Stroke volume decreased from 94±13 to 84±10 ml (p<0.05) and pulse pressure from 56±11 to 46±9 mmHg (p<0.05) in part through reductions in stroke volume. The figure illustrates individual data on aortic properties (red diamonds = women). In contrast to the more consistent changes in aortic area, stroke volume, and pulse pressure, aortic distensibility, compliance, and pulse wave velocity responses show substantial inter-individual variability. Conclusion The important finding of our study is that 60 days strict head down bedrest elicit consistent changes in ascending aortic area, pulse pressure, and stroke volume. The resulting changes in vascular loading conditions likely confound vascular function measurements, both, in head down bedrest studies and in space.

Item URL in elib:https://elib.dlr.de/185670/
Document Type:Conference or Workshop Item (Poster)
Title:AORTIC VESSEL WALL PROPERTIES DURING 60 DAYS STRICT HEAD DOWN TILT BEDREST - PRELIMINARY RESULTS OF AGBRESA
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Moestl, S.German Aerospace Center, Cologne, GermanyUNSPECIFIED
Rabineau, J.LPHYS, Université Libre de Bruxelles, Brussels, BelgiumUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIED
Caiani, E.G.Politecnico di Milano, Electronics, Information and Biomedical Engineering Department, Milano, ItalyUNSPECIFIED
Migeotte, P.-F.Laboratory of Physics and Physiology (LPHYS), Université libre de Bruxelles, Bruxelles, BelgiumUNSPECIFIED
Bachler, M.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIED
Hametner, B.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIED
Wassertheurer, S.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIED
Jordan, JInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Tank, JensCardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Date:2020
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Head down tilt; preliminary results; AGBRESA
Event Title:NASA Human Research Program Investigators' Workshop
Event Location:Galveston
Event Type:international Conference
Event Dates:27.01.2020
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:08 Apr 2022 13:33
Last Modified:08 Apr 2022 13:33

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