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PULSED DOPPLER FROM THE SUPRASTERNAL NOTCH SYSTEMATICALLY UNDERESTIMATES MEAN BLOOD FLOW VELOCITY IN THE ASCENDING AORTA COMPARED TO PHASE CONTRAST MRI

Naendrup, I. and Moestl, S. and Hoffmann, F. and Kempter, K. and von Waechter, A. and Jordan, J and Tank, Jens (2020) PULSED DOPPLER FROM THE SUPRASTERNAL NOTCH SYSTEMATICALLY UNDERESTIMATES MEAN BLOOD FLOW VELOCITY IN THE ASCENDING AORTA COMPARED TO PHASE CONTRAST MRI. NASA Human Research Program Investigators' Workshop, 27.01.2020, Galveston.

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Abstract

Background Continuous pulsed-wave Doppler readings of flow velocity in the ascending aorta from the suprasternal position (sCD) are widely used in estimating stroke volume, particularly during physiological challenge maneuvers such as head-up tilt testing. Stroke volume is derived from velocity time integrals and vessel area. We compared the sCD against an established gold standard. Methods In 12 healthy women and men, we obtained 2D cross sectional, velocity encoded phase contrast MRI of the ascending aorta (2DMRI) and sCD to measure mean blood flow velocity (Vmean) at the ascending aorta. We compared sCD insonation depth to the distance between Doppler probe and sinotubular junction measured by MRI. Within an aortic 4D-Flow dataset, allowing flow measurements in every anatomical point along the ascending aorta, Vmean was determined at the sCD measurement point for comparison. Results sCD significantly underestimated Vmean compared with 2DMRI at the sinotubular junction (Vmean 2DMRI – Vmean sCD = 24.42 cm/s ± 12.55 cm/s, p = <0.001). Moreover, sCD sampled flow velocities 21.8 mm ± 7mm (p = <0.001) or 26% off the sinotubular junction. Yet, depth and velocity differences between sCD and 2DMRI were not correlated with each other (Pearson r = -0.147; p = 0.648). When we applied 4DMRI to assess flow velocity at the sCD measurement site, the Vmean difference between methodologies was reduced to 9.1 cm/s ± 12.38 cm/s (p = 0.035). Conclusion sCD profoundly underestimates Vmean in the ascending aorta compared to 4DMRI. The methodology has important limitations in accessing the ideal position for aortic flow measurements and precise information regarding the position of data acquisition for vessel area quantification cannot be ascertained. Overall, sCD is of limited utility in measuring absolute stroke volume

Item URL in elib:https://elib.dlr.de/185662/
Document Type:Conference or Workshop Item (Poster)
Title:PULSED DOPPLER FROM THE SUPRASTERNAL NOTCH SYSTEMATICALLY UNDERESTIMATES MEAN BLOOD FLOW VELOCITY IN THE ASCENDING AORTA COMPARED TO PHASE CONTRAST MRI
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Naendrup, I.UNSPECIFIEDUNSPECIFIED
Moestl, S.German Aerospace Center, Cologne, GermanyUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIED
Kempter, K.UNSPECIFIEDUNSPECIFIED
von Waechter, A.UNSPECIFIEDUNSPECIFIED
Jordan, JInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Tank, JensCardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Date:2020
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Pulsed doppler; suprasternal notch; ascending aorta; MRI
Event Title:NASA Human Research Program Investigators' Workshop
Event Location:Galveston
Event Type:international Conference
Event Dates:27.01.2020
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:08 Apr 2022 13:35
Last Modified:08 Apr 2022 13:35

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