elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Abstract 041: Hypoxic Peripheral Chemoreceptor Activation Engages Sympathetic Brainstem and Hypothalamic Nuclei in Human Subjects

Gerlach, D.A. and Manuel, J. and Hoff, Alex and Kronsbein, H. and Hoffmann, F. and Heusser, K. and Diedrich, A. and Ehmke, H. and Jordan, J. and Tank, Jens and Beissner, F. (2019) Abstract 041: Hypoxic Peripheral Chemoreceptor Activation Engages Sympathetic Brainstem and Hypothalamic Nuclei in Human Subjects. In: HYPERTENSION, 74. American Heart Association Scientific Sessions 2019, Philadelphia (USA). doi: 10.1161/hyp.74.suppl_1.041.

Full text not available from this repository.

Official URL: https://doi.org/10.1161/hyp.74.suppl_1.041

Abstract

Peripheral carotid chemoreceptors, which raise sympathetic activation at the brainstem level, may serve as targets for antihypertensive therapy. However, human peripheral chemoreflex regulation in the brainstem is poorly understood due to lack of suitable methodologies. Therefore, we combined measurements of beat-by-beat blood pressure and SpO2, and high-resolution functional magnetic resonance imaging (fMRI) to elucidate human brainstem circuits engaged through hypoxic peripheral chemoreceptor activation. We submitted 12 healthy men (29.7 ±6.6 years; 24.0 ±1.86 kg/m2) to five hypoxic episodes by breathing 10% oxygen for 180 seconds followed by 90 seconds normoxia during multiband fMRI brain acquisitions. We monitored continuous finger arterial blood pressure using customized hardware, ECG, and SpO2. Brainstem and hypothalamus fMRI images were analyzed to identify nuclei involved in peripheral chemoreflex processing. Systolic blood pressure (SBP) and SpO2 time courses were correlated with the blood-oxygen-level dependent signals with a general linear model. With hypoxia, SpO2 decreased by 12.32 ±3.68% (p < 0.01), heart rate increased 13.86 ±3.47 bpm (p < 0.01), and SBP decreased with hypoxia 5.45 ±5.5 mmHg (p < 0.01). In the brainstem, the nucleus tractus solitarii (t-values: SpO2: 5.9; SBP: 4.79), the caudal ventrolateral medulla (SpO2: 5.61; SBP: 5.59), intermediate reticular nucleus (SpO2: 4.7, SBP: 5.98), nucleus ambiguus (SpO2: 5.03, SBP: 5.59), dorsal motor nucleus of the vagal nerve (SBP: 4.79), and inferior olive (SpO2: 4.7, SBP: 6.16) were identified with high sensitivity and corrected for multiple comparisons (p < 0.01). Furthermore, we observed activation of the following hypothalamic nuclei: paraventricular nucleus (SpO2: 7.67), anterior and lateral hypothalamic area (SpO2: 7.67, SBP: 4.79), supraoptic nucleus, and tuberomammillary nucleus (SpO2: 7.07). High-resolution brainstem fMRI during repeated hypoxia traces brainstem circuits engaged by peripheral chemoreceptors. The methodology can be applied to study peripheral chemoreceptor contributions to human cardiovascular disease and may have utility in identifying patients likely to respond to peripheral chemoreceptor modulation.

Item URL in elib:https://elib.dlr.de/185653/
Document Type:Conference or Workshop Item (Speech)
Title:Abstract 041: Hypoxic Peripheral Chemoreceptor Activation Engages Sympathetic Brainstem and Hypothalamic Nuclei in Human Subjects
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Gerlach, D.A.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0001-7044-6065
Manuel, J.Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany and Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Hoff, AlexAlex.Hoff (at) dlr.deUNSPECIFIED
Kronsbein, H.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIED
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany; Karsten.Heusser (at) dlr.dehttps://orcid.org/0000-0002-2571-5585
Diedrich, A.UNSPECIFIEDUNSPECIFIED
Ehmke, H.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Tank, JensCardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Beissner, F.Somatosensory and Autonomic Therapy Research, Institute for Neuroradiology, Hannover Medical School, Hannover , DEUNSPECIFIED
Date:2019
Journal or Publication Title:HYPERTENSION
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:74
DOI :10.1161/hyp.74.suppl_1.041
Status:Published
Keywords:MRI; Hypoxia
Event Title:American Heart Association Scientific Sessions 2019
Event Location:Philadelphia (USA)
Event Type:international Conference
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:08 Apr 2022 13:28
Last Modified:08 Apr 2022 13:28

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.