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Dissociation of bone resorption and formation in spaceflight and simulated microgravity: Potential role of myokines and osteokines?

Lau, Patrick and Vico, Laurence and Rittweger, Jörn (2022) Dissociation of bone resorption and formation in spaceflight and simulated microgravity: Potential role of myokines and osteokines? Biomedicines, 10 (2), p. 342. Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390/biomedicines10020342. ISSN 2227-9059.

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Official URL: https://doi.org/10.3390/biomedicines10020342

Abstract

The dissociation of bone formation and resorption is an important physiological process during spaceflight. It also occurs during local skeletal unloading or immobilization, such as in people with neuromuscular disorders or those who are on bed rest. Under these conditions, the physiological systems of the human body are perturbed down to the cellular level. Through the absence of mechanical stimuli, the musculoskeletal system and, predominantly, the postural skeletal muscles are largely affected. Despite in-flight exercise countermeasures, muscle wasting and bone loss occur, which are associated with spaceflight duration. Nevertheless, countermeasures can be effective, especially by preventing muscle wasting to rescue both postural and dynamic as well as muscle performance. Thus far, it is largely unknown how changes in bone microarchitecture evolve over the long term in the absence of a gravity vector and whether bone loss incurred in space or following the return to the Earth fully recovers or partly persists. In this review, we highlight the different mechanisms and factors that regulate the humoral crosstalk between the muscle and the bone. Further we focus on the interplay between currently known myokines and osteokines and their mutual regulation.

Item URL in elib:https://elib.dlr.de/148750/
Document Type:Article
Title:Dissociation of bone resorption and formation in spaceflight and simulated microgravity: Potential role of myokines and osteokines?
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Lau, PatrickPatrick.Lau (at) dlr.dehttps://orcid.org/0000-0002-7290-5875
Vico, LaurenceUniversity of St. Etienne, St. Etienne, FranceUNSPECIFIED
Rittweger, JörnMuscle and Bone Metabolism Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Joern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Date:1 February 2022
Journal or Publication Title:Biomedicines
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:10
DOI :10.3390/biomedicines10020342
Page Range:p. 342
Publisher:Multidisciplinary Digital Publishing Institute (MDPI)
Series Name:MDPI Biomedicines
ISSN:2227-9059
Status:Published
Keywords:bone remodeling; bone formation; bone resorption; unloading; disuse; space medicine,
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Bone metabolism and structural adaptation
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Chiodo, Annette
Deposited On:17 Feb 2022 13:27
Last Modified:17 Feb 2022 13:27

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