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Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

Behr, Matthias and Ganesan, Kathirvel (2022) Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology. Materials, 15 (3), p. 1041. Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390/ma15031041. ISSN 1996-1944.

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Official URL: https://www.mdpi.com/1996-1944/15/3/1041

Abstract

Improved wound healing of burnt skin and skin lesions, as well as medical implants and replacement products, requires the support of synthetical matrices. Yet, producing synthetic biocompatible matrices that exhibit specialized flexibility, stability, and biodegradability is challenging. Synthetic chitin/chitosan matrices may provide the desired advantages for producing specialized grafts but must be modified to improve their properties. Synthetic chitin/chitosan hydrogel and aerogel techniques provide the advantages for improvement with a bioinspired view adapted from the natural molecular toolbox. To this end, animal genetics provide deep knowledge into which molecular key factors decisively influence the properties of natural chitin matrices. The genetically identified proteins and enzymes control chitin matrix assembly, architecture, and degradation. Combining synthetic chitin matrices with critical biological factors may point to the future direction with engineering materials of specific properties for biomedical applications such as burned skin or skin blistering and extensive lesions due to genetic diseases.

Item URL in elib:https://elib.dlr.de/148708/
Document Type:Article
Title:Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Behr, Matthiasmatthias.behr (at) uni-leipzig.dehttps://orcid.org/0000-0001-9869-1257
Ganesan, Kathirvelk.ganesan (at) dlr.dehttps://orcid.org/0000-0002-4876-5366
Date:28 January 2022
Journal or Publication Title:Materials
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:15
DOI :10.3390/ma15031041
Page Range:p. 1041
Publisher:Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:1996-1944
Status:Published
Keywords:wound healing; materials; skin substitutes; aerogel; chitin; chitosan; insect; drosophila; proteins; obst-A
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Transport
HGF - Program Themes:Road Transport
DLR - Research area:Transport
DLR - Program:V ST Straßenverkehr
DLR - Research theme (Project):V - NGC Fahrzeugstruktur II
Location: Köln-Porz
Institutes and Institutions:Institute of Materials Research > Aerogels and Aerogel Composites
Deposited By: Ganesan, Dr. Kathirvel
Deposited On:09 Feb 2022 09:15
Last Modified:09 Feb 2022 09:15

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