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Testing Laser-Structured Antimicrobial Surfaces Under Space Conditions: The Design of the ISS Experiment BIOFILMS

Siems, Katharina and Müller, Daniel W. and Maertens, Laurens and Ahmed, Aisha and Van Houdt, Rob and Mancinelli, Rocco L. and Baur, Sandra and Brix, Kristina and Kautenburger, Ralf and Caplin, Nicol and Krause, Jutta and Demets, Rene and Vukich, Marco and Tortora, Alessandra and Roesch, Christian and Holland, Gudrun and Laue, Michael and Mücklich, Frank and Moeller, Ralf (2022) Testing Laser-Structured Antimicrobial Surfaces Under Space Conditions: The Design of the ISS Experiment BIOFILMS. Frontiers in Space Technologies, 2, p. 773244. Frontiers Media S.A.. doi: 10.3389/frspt.2021.773244. ISSN 2673-5075.

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Official URL: http://dx.doi.org/10.3389/frspt.2021.773244

Abstract

Maintaining crew health and safety are essential goals for long-term human missions to space. Attaining these goals requires the development of methods and materials for sustaining the crew’s health and safety. Paramount is microbiological monitoring and contamination reduction. Microbial biofilms are of special concern, because they can cause damage to spaceflight equipment and are difficult to eliminate due to their increased resistance to antibiotics and disinfectants. The introduction of antimicrobial surfaces for medical, pharmaceutical and industrial purposes has shown a unique potential for reducing and preventing biofilm formation. This article describes the development process of ESA’s BIOFILMS experiment, that will evaluate biofilm formation on various antimicrobial surfaces under spaceflight conditions. These surfaces will be composed of different metals with and without specified surface texture modifications. Staphylococcus capitis subsp. capitis, Cupriavidus metallidurans and Acinetobacter radioresistens are biofilm forming organisms that have been chosen as model organisms. The BIOFILMS experiment will study the biofilm formation potential of these organisms in microgravity on the International Space Station on inert surfaces (stainless steel AISI 304) as well as antimicrobial active copper (Cu) based metals that have undergone specific surface modification by Ultrashort Pulsed Direct Laser Interference Patterning (USP-DLIP). Data collected in 1 x g has shown that these surface modifications enhance the antimicrobial activity of Cu based metals. In the scope of this, the interaction between the surfaces and bacteria, which is highly determined by topography and surface chemistry, will be investigated. The data generated will be indispensable for the future selection of antimicrobial materials in support of human- and robotic-associated activities in space exploration.

Item URL in elib:https://elib.dlr.de/148004/
Document Type:Article
Title:Testing Laser-Structured Antimicrobial Surfaces Under Space Conditions: The Design of the ISS Experiment BIOFILMS
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Siems, KatharinaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Katharina.Siems (at) dlr.dehttps://orcid.org/0000-0001-7349-0846
Müller, Daniel W.Department of Materials Science and Engineering, University of Saarland, Saarbrücken, GermanyUNSPECIFIED
Maertens, LaurensMicrobiology Unit, Interdisciplinary Biosciences, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium and Research Unit in Microorganisms Biology (URBM), Narilis Institute, University of Namur, Namur, BelgiumUNSPECIFIED
Ahmed, AishaDepartment of Materials Science and Engineering, University of Saarland, Saarbrücken, GermanyUNSPECIFIED
Van Houdt, RobMicrobiology Unit, Interdisciplinary Biosciences, Belgian Nuclear Research Centre (SCK CEN), Mol, BelgiumUNSPECIFIED
Mancinelli, Rocco L.NASA Ames Research Center/Bay Area Environmental Research Institute, Petaluma, CA, United StatesUNSPECIFIED
Baur, SandraDepartment of Inorganic Solid State Chemistry, Elemental Analysis, University of Saarland, Saarbrücken, GermanyUNSPECIFIED
Brix, KristinaDepartment of Inorganic Solid State Chemistry, Elemental Analysis, University of Saarland, Saarbrücken, GermanyUNSPECIFIED
Kautenburger, RalfDepartment of Inorganic Solid State Chemistry, Elemental Analysis, University of Saarland, Saarbrücken, GermanyUNSPECIFIED
Caplin, NicolESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Krause, JuttaESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Demets, ReneESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Vukich, MarcoESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Tortora, AlessandraKayser Italia Srl, Livorno, ItalyUNSPECIFIED
Roesch, ChristianBiotechnology Space Support Center (BIOTESC), Lucerne University of Applied Sciences and Arts, Lucerne, SwitzerlandUNSPECIFIED
Holland, GudrunRobert-Koch-Institute, Berlin, GermanyUNSPECIFIED
Laue, MichaelRobert-Koch-Institute, Berlin, GermanyUNSPECIFIED
Mücklich, FrankDepartment of Materials Science and Engineering, University of Saarland, Saarbrücken, GermanyUNSPECIFIED
Moeller, RalfRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; ralf.moeller (at) dlr.de and Natural Sciences Department, University of Applied Sciences Bonn-Rhein-Sieg (BRSU), D-53359 Rheinbach, Germanyhttps://orcid.org/0000-0002-2371-0676
Date:3 January 2022
Journal or Publication Title:Frontiers in Space Technologies
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:No
In ISI Web of Science:No
Volume:2
DOI :10.3389/frspt.2021.773244
Page Range:p. 773244
Publisher:Frontiers Media S.A.
ISSN:2673-5075
Status:Published
Keywords:biofilms, direct laser interference patterning technique (DLIP), contamination (equipment), antimicobial, surfaces
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Project ISS LIFE 2.0
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:10 Jan 2022 08:23
Last Modified:10 Jan 2022 08:23

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