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Cerebral A₁ adenosine receptor availability in female and male participants and its relationship to sleep

Pierling, A.L. and Elmenhorst, E.-M. and Lange, D. and Hennecke, E. and Baur, D.M. and Beer, S. and Kroll, T. and Neumaier, B. and Aeschbach, D. and Bauer, A. and Landolt, H.P. and Elmenhorst, D. (2021) Cerebral A₁ adenosine receptor availability in female and male participants and its relationship to sleep. NeuroImage, 31, p. 118695. Elsevier. doi: 10.1016/j.neuroimage.2021.118695. ISSN 1053-8119.

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Official URL: https://www.sciencedirect.com/science/article/pii/S105381192100968X?via%3Dihub

Abstract

The neuromodulator adenosine and its receptors are mediators of sleep-wake regulation which is known to differ between sexes. We, therefore, investigated sex differences in A₁ adenosine receptor (A₁AR) availability in healthy human subjects under well-rested conditions using [¹⁸F]CPFPX and positron emission tomography (PET). [¹⁸F]CPFPX PET scans were acquired in 50 healthy human participants (20 females; mean age ± SD 28.0 ± 5.3 years). Mean binding potential (BPND; Logan's reference tissue model with cerebellum as reference region) and volume of distribution (VT) values were calculated in 12 and 15 grey matter brain regions, respectively. [¹⁸F]CPFPX BPND was higher in females compared to males in all investigated brain regions (p < 0.025). The largest differences were found in the pallidum and anterior cingulate cortex, where mean BPND values were higher by 29 % in females than in males. In females, sleep efficiency correlated positively and sleep latency negatively with BPND in most brain regions. VT values did not differ between sexes. Sleep efficiency correlated positively with VT in most brain regions in female participants. In conclusion, our analysis gives a first indication for potential sex differences in A1AR availability even under well-rested conditions. A₁AR availability as measured by [¹⁸F]CPFPX BPND is higher in females compared to males. Considering the involvement of adenosine in sleep-wake control, this finding might partially explain the known sex differences in sleep efficiency and sleep latency.

Item URL in elib:https://elib.dlr.de/147568/
Document Type:Article
Title:Cerebral A₁ adenosine receptor availability in female and male participants and its relationship to sleep
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Pierling, A.L.UNSPECIFIEDUNSPECIFIED
Elmenhorst, E.-M.Eva-Maria.Elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Lange, D.denise.lange (at) dlr.deUNSPECIFIED
Hennecke, E.eva.hennecke (at) dlr.deUNSPECIFIED
Baur, D.M.UNSPECIFIEDUNSPECIFIED
Beer, S.UNSPECIFIEDUNSPECIFIED
Kroll, T.UNSPECIFIEDUNSPECIFIED
Neumaier, B.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Landolt, H.P.UNSPECIFIEDUNSPECIFIED
Elmenhorst, D.UNSPECIFIEDUNSPECIFIED
Date:15 December 2021
Journal or Publication Title:NeuroImage
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:31
DOI :10.1016/j.neuroimage.2021.118695
Page Range:p. 118695
Publisher:Elsevier
ISSN:1053-8119
Status:Published
Keywords:Adenosine receptors, A₁AR, PET, Sex differences, [¹⁸F]CPFPX, Sleep
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:Air Transportation and Impact
DLR - Research area:Aeronautics
DLR - Program:L AI - Air Transportation and Impact
DLR - Research theme (Project):L - Human Factors, R - no assignment
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Sender, Alina
Deposited On:06 Jan 2022 12:25
Last Modified:10 Jan 2022 08:35

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