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Daytime eating prevents internal circadian misalignment and glucose intolerance in night work

Chellappa, S.L. and Qian, J. and Vujovic, N. and Morris, Ch.J. and Nedeltcheva, A. and Nguyen, H. and Rahman, N. and Heng, S.W. and Kelly, L. and Kerlin-Monteiro, K. and Srivastav, S. and Wang, W. and Aeschbach, D. and Czeisler, C.A. and Shea, S.A. and Adler, G.K. and Garaulet, M. and Scheer, F.A.J.L. (2021) Daytime eating prevents internal circadian misalignment and glucose intolerance in night work. Science Advances, 7 (49), eabg9910. American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.abg9910. ISSN 2375-2548.

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Official URL: https://www.science.org/doi/10.1126/sciadv.abg9910

Abstract

Night work increases diabetes risk. Misalignment between the central circadian “clock” and daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal misalignment between central and peripheral circadian rhythms. Whether appropriate circadian alignment of eating can prevent internal circadian misalignment and glucose intolerance is unknown. In a 14-day circadian paradigm, we assessed glycemic control during simulated night work with either nighttime or daytime eating. Assessment of central (body temperature) and peripheral (glucose and insulin) endogenous circadian rhythms happened during constant routine protocols before and after simulated night work. Nighttime eating led to misalignment between central and peripheral (glucose) endogenous circadian rhythms and impaired glucose tolerance, whereas restricting meals to daytime prevented it. These findings offer a behavioral approach to preventing glucose intolerance in shift workers.

Item URL in elib:https://elib.dlr.de/147472/
Document Type:Article
Title:Daytime eating prevents internal circadian misalignment and glucose intolerance in night work
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Chellappa, S.L.UNSPECIFIEDhttps://orcid.org/0000-0002-6190-464X
Qian, J.UNSPECIFIEDUNSPECIFIED
Vujovic, N.UNSPECIFIEDUNSPECIFIED
Morris, Ch.J.UNSPECIFIEDUNSPECIFIED
Nedeltcheva, A.UNSPECIFIEDUNSPECIFIED
Nguyen, H.UNSPECIFIEDUNSPECIFIED
Rahman, N.UNSPECIFIEDUNSPECIFIED
Heng, S.W.UNSPECIFIEDUNSPECIFIED
Kelly, L.UNSPECIFIEDUNSPECIFIED
Kerlin-Monteiro, K.UNSPECIFIEDUNSPECIFIED
Srivastav, S.UNSPECIFIEDUNSPECIFIED
Wang, W.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Czeisler, C.A.UNSPECIFIEDUNSPECIFIED
Shea, S.A.UNSPECIFIEDUNSPECIFIED
Adler, G.K.UNSPECIFIEDUNSPECIFIED
Garaulet, M.UNSPECIFIEDUNSPECIFIED
Scheer, F.A.J.L.UNSPECIFIEDUNSPECIFIED
Date:3 December 2021
Journal or Publication Title:Science Advances
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:7
DOI :10.1126/sciadv.abg9910
Page Range:eabg9910
Publisher:American Association for the Advancement of Science (AAAS)
ISSN:2375-2548
Status:Published
Keywords:Night work, circadian, glucose intolerance, eating
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:Air Transportation and Impact
DLR - Research area:Aeronautics
DLR - Program:L AI - Air Transportation and Impact
DLR - Research theme (Project):L - Human Factors
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Sender, Alina
Deposited On:14 Dec 2021 13:41
Last Modified:21 Dec 2021 09:41

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