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Intramuscular lipid concentration increased in localized regions of the lumbar muscles following 60-day bedrest

De Martino, Enrico and Hides, Julie and Elliott, James M. and Hoggarth, Mark and Zange, Jochen and Lindsay, Kirsty and Debuse, Dorothée and Winnard, Andrew and Beard, David and Cook, Jonathan A. and Salomoni, Sauro E. and Weber, Tobias and Scott, Jonathan and Hodges, Paul W. and Caplan, Nick (2022) Intramuscular lipid concentration increased in localized regions of the lumbar muscles following 60-day bedrest. Spine Journal, 22 (4), pp. 616-628. Elsevier. doi: 10.1016/j.spinee.2021.11.007. ISSN 1529-9430.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34813960

Abstract

BACKGROUND CONTEXT: Prolonged bedrest induces accumulation of intramuscular lipid concentration (ILC) in the lumbar musculature; however, spatial distribution of ILC has not been determined. Artificial gravity (AG) mitigates some adaptations induced by 60 day bedrest by creating a head-to-feet force while participants are in a supine position. PURPOSE: To quantify the spatial distribution of accumulation of ILC in the lumbar musculature after 60 day bedrest, and whether this can be mitigated by AG exposure. STUDY DESIGN: Prospective longitudinal study. PATIENT SAMPLE: Twenty-four healthy individuals (8 females) participated in the study: Eight received 30 min continuous AG (cAG); Eight received 6 x 5 min AG (iAG), interspersed with rests; Eight were not exposed to AG (CRTL). OUTCOME MEASURES: From 3T magnetic resonance imaging (MRI), axial images were selected to assess lumbar multifidus (LM), lumbar erector spinae (LES), quadratus lumborum (QL), and psoas major (PM) muscles from L1/L2 to L5/S1 intervertebral disc levels. Chemical shift-based 2-echo lipid and/or water Dixon sequence was used to measure tissue composition. Each lumbar muscle was segmented into four equal quartiles (from medial to lateral). METHODS: Participants arrived at the facility for the baseline data collection before undergoing a 60 day strict 6 degrees head-down tilt (HDT) bedrest period. MRI of the lumbopelvic region was conducted at baseline and Day-59 of bedrest. Participants performed all activities, including hygiene, in 6 degrees HDT and were discouraged from moving excessively or unnecessarily. RESULTS: At the L4/L5 and L5/S1 intervertebral disc levels, 60-day bedrest induced a greater increase in ILC in medial and lateral regions ( approximately +4%) of the LM than central regions ( approximately +2%; p<.05). A smaller increase in ILC was induced in the lateral region of LES ( approximately +1%) at L1/L2 and L2/L3 than at the centro-medial region ( approximately +2%; p<.05). There was no difference between CRTL and intervention groups. CONCLUSIONS: Inhomogeneous spatial distribution of accumulation of ILC was found in the lumbar musculature after 60 day bedrest. These findings might reflect pathophysiological mechanisms related to muscle disuse and contribute to localized lumbar spine dysfunction. Altered spatial distribution of ILC may impair lumbar spine function after prolonged body unloading, which could increase injury risk to vulnerable soft tissues, such as the lumbar intervertebral discs. These novel results may represent a new biomarker of lumbar deconditioning for astronauts, bedridden, sedentary individuals, or those with chronic back pain. Changes are potentially modifiable but not by the AG protocols tested here.

Item URL in elib:https://elib.dlr.de/147439/
Document Type:Article
Title:Intramuscular lipid concentration increased in localized regions of the lumbar muscles following 60-day bedrest
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
De Martino, EnricoNorthumbria University, Newcastle, UKhttps://orcid.org/0000-0003-3211-3723
Hides, JulieJulie.Hides (at) acu.edu.auhttps://orcid.org/0000-0002-1830-8121
Elliott, James M.University of Sydney, Sydney, Australiahttps://orcid.org/0000-0003-4821-6831
Hoggarth, Markmark.hoggarth (at) northwestern.eduhttps://orcid.org/0000-0001-6516-5840
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Lindsay, KirstyNorthumbria University, Newcastle upon Tyne, United Kingdomhttps://orcid.org/0000-0002-3873-956X
Debuse, DorothéeNorthumbria University, Newcastle, UKUNSPECIFIED
Winnard, AndrewNorthumbria University, Newcastle, UKhttps://orcid.org/0000-0001-5985-659X
Beard, DavidUniversity of Oxford, UKhttps://orcid.org/0000-0001-7884-6389
Cook, Jonathan A.University of Oxford, UKhttps://orcid.org/0000-0002-4156-6989
Salomoni, Sauro E.University of Queenslad: Brisbane, Queensland, AUhttps://orcid.org/0000-0001-7616-9003
Weber, Tobiastobias.weber (at) esa.intUNSPECIFIED
Scott, JonathanJonathan.Scott (at) wylelabs.deUNSPECIFIED
Hodges, Paul W.University of Queensland, Brisbane, Queensland, Australiahttps://orcid.org/0000-0002-1206-9107
Caplan, Nicknick.caplan (at) northumbria.ac.ukUNSPECIFIED
Date:2022
Journal or Publication Title:Spine Journal
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:22
DOI:10.1016/j.spinee.2021.11.007
Page Range:pp. 616-628
Publisher:Elsevier
ISSN:1529-9430
Status:Published
Keywords:Bed Rest/adverse effects Female Humans Lipids Longitudinal Studies Lumbar Vertebrae/diagnostic imaging Magnetic Resonance Imaging Male Paraspinal Muscles/pathology Prospective Studies AGBRESA study Adipose tissue Dixon sequence Fatty infiltration Lumbar multifidus Magnetic resonance imaging Short-arm centrifugation Space flight analog
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism, R - Human performance under altered gravity conditions
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:29 Jun 2022 14:52
Last Modified:05 Jul 2022 13:48

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