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Gluteal Muscle Atrophy and Increased Intramuscular Lipid Concentration Are Not Mitigated by Daily Artificial Gravity Following 60-Day Head-Down Tilt Bed Rest

Tran, Vienna and De Martino, Enrico and Hides, Julie and Cable, Gordon and Elliott, James M. and Hoggarth, Mark and Zange, Jochen and Lindsay, Kirsty and Debuse, Dorothée and Winnard, Andrew and Beard, David and Cook, Jonathan A. and Salomoni, Sauro E. and Weber, Tobias and Scott, Jonathan and Hodges, Paul W. and Caplan, Nick (2021) Gluteal Muscle Atrophy and Increased Intramuscular Lipid Concentration Are Not Mitigated by Daily Artificial Gravity Following 60-Day Head-Down Tilt Bed Rest. Frontiers in Physiology, 12, p. 745811. Frontiers Media S.A. doi: 10.3389/fphys.2021.745811. ISSN 1664-042X.

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Official URL: https://doi.org/10.3389/fphys.2021.745811


Exposure to spaceflight and head-down tilt (HDT) bed rest leads to decreases in the mass of the gluteal muscle. Preliminary results have suggested that interventions, such as artificial gravity (AG), can partially mitigate some of the physiological adaptations induced by HDT bed rest. However, its effect on the gluteal muscles is currently unknown. This study investigated the effects of daily AG on the gluteal muscles during 60-day HDT bed rest. Twenty-four healthy individuals participated in the study: eight received 30 min of continuous AG; eight received 6 × 5 min of AG, interspersed with rest periods; eight belonged to a control group. T1-weighted Dixon magnetic resonance imaging of the hip region was conducted at baseline and day 59 of HDT bed rest to establish changes in volumes and intramuscular lipid concentration (ILC). Results showed that, across groups, muscle volumes decreased by 9.2% for gluteus maximus (GMAX), 8.0% for gluteus medius (GMED), and 10.5% for gluteus minimus after 59-day HDT bed rest (all p < 0.005). The ILC increased by 1.3% for GMAX and 0.5% for GMED (both p < 0.05). Neither of the AG protocols mitigated deconditioning of the gluteal muscles. Whereas all gluteal muscles atrophied, the ratio of lipids to intramuscular water increased only in GMAX and GMED muscles. These changes could impair the function of the hip joint and increased the risk of falls. The deconditioning of the gluteal muscles in space may negatively impact the hip joint stability of astronauts when reexpose to terrestrial gravity.

Item URL in elib:https://elib.dlr.de/145642/
Document Type:Article
Title:Gluteal Muscle Atrophy and Increased Intramuscular Lipid Concentration Are Not Mitigated by Daily Artificial Gravity Following 60-Day Head-Down Tilt Bed Rest
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Tran, ViennaAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australiahttps://orcid.org/0000-0003-4110-4888UNSPECIFIED
De Martino, EnricoNorthumbria University, Newcastle, UKhttps://orcid.org/0000-0003-3211-3723UNSPECIFIED
Hides, JulieUNSPECIFIEDhttps://orcid.org/0000-0002-1830-8121UNSPECIFIED
Cable, GordonAdelaide Medical School, The University of Adelaide, Adelaide, SA, AustraliaUNSPECIFIEDUNSPECIFIED
Elliott, James M.University of Sydney, Sydney, Australiahttps://orcid.org/0000-0003-4821-6831UNSPECIFIED
Hoggarth, MarkUNSPECIFIEDhttps://orcid.org/0000-0001-6516-5840UNSPECIFIED
Zange, JochenUNSPECIFIEDhttps://orcid.org/0000-0003-1822-0952133724719
Lindsay, KirstyNorthumbria University, Newcastle upon Tyne, United Kingdomhttps://orcid.org/0000-0002-3873-956XUNSPECIFIED
Debuse, DorothéeNorthumbria University, Newcastle, UKUNSPECIFIEDUNSPECIFIED
Winnard, AndrewNorthumbria University, Newcastle, UKhttps://orcid.org/0000-0001-5985-659XUNSPECIFIED
Beard, DavidUniversity of Oxford, UKhttps://orcid.org/0000-0001-7884-6389UNSPECIFIED
Cook, Jonathan A.University of Oxford, UKhttps://orcid.org/0000-0002-4156-6989UNSPECIFIED
Salomoni, Sauro E.University of Queenslad: Brisbane, Queensland, AUhttps://orcid.org/0000-0001-7616-9003UNSPECIFIED
Hodges, Paul W.University of Queensland, Brisbane, Queensland, Australiahttps://orcid.org/0000-0002-1206-9107UNSPECIFIED
Date:11 November 2021
Journal or Publication Title:Frontiers in Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:p. 745811
Publisher:Frontiers Media S.A
Series Name:Front. Physiol.
Keywords:AGBRESA bed rest, Dixon sequence, short-arm centrifugation, intramuscular fatty infiltration, gluteal muscles, muscle atrophy
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:16 Nov 2021 13:52
Last Modified:25 Apr 2023 12:18

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