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Short-term hypercaloric diet decreases hypothalamic and brainstem functional connectivity in humans

Gerlach, D.A. and Manuel, J. and Ewald, A.C. and Hoff, A. and De Gioannis, R. and Heer, M. and Tank, J. and Jordan, J. (2021) Short-term hypercaloric diet decreases hypothalamic and brainstem functional connectivity in humans. 32nd International Symposium on the Autonomic Nervous System, 04.-06. November 2021, Virtual Conference.

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Abstract

Hypothalamic and brainstem pathways, particularly the leptin melanocortin system, regulate energy balance through adjustments in autonomic efferent activity. Disordered regulation of the system predisposes to obesity and obesity-associated arterial hypertension. We applied high-resolution subcortical functional magnetic resonance imaging (fMRI) to test whether short-term increase in energy intake elicit functional connectivity changes between and within hypothalamus and brainstem nuclei in human beings. We submitted 20 subjects (7 women, 26.7±8 years; 22.6±2 kg/m2) to 5 days hypercaloric (25% increase of energy intake by fat) or normocaloric diets in a randomized crossover fashion with a washout period between interventions. We obtained high resolution brainstem and hypothalamus fMRI (3T PET/MRI, Siemens mMR Biograph). Then, we applied masked independent component analysis for resting state measurements and defined functional connectivity changes using dual regression between and within relevant regions. We observed significantly decreased functional connectivity after hypercaloric compared to normocaloric diet. In particularly, connectivity decreased between hypothalamic regions involved in metabolic regulation such as ventromedial and arcuate nuclei, mamillary bodies, and lateral and posterior hypothalamic areas. In the brainstem, functional connectivity decreased between rostral ventrolateral medulla and the inferior olive; two regions involved in sympathetic regulation. Moreover, connectivity decreased between hypothalamus and brainstem involving several nuclei: ventromedial, arcuate and supraoptic nuclei in the hypothalamus; as well as the solitary, raphe and inferior olivary nuclei in the brainstem. We conclude that several days hypercaloric dieting produces significant resting state functional connectivity changes within and between hypothalamus and brainstem areas known to regulate efferent autonomic activity. The methodology may have utility in elucidating how metabolic and cardiovascular autonomic control are integrated in human beings and how perturbed regulation contributes to cardiometabolic disease.

Item URL in elib:https://elib.dlr.de/145023/
Document Type:Conference or Workshop Item (Speech, Poster)
Title:Short-term hypercaloric diet decreases hypothalamic and brainstem functional connectivity in humans
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Gerlach, D.A.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0001-7044-6065
Manuel, J.Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany and Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Ewald, A.C.Ann.Ewald (at) dlr.deUNSPECIFIED
Hoff, A.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
De Gioannis, R.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Heer, M.Institut für Ernährungswissenschaft, Universität Bonn, GermanyUNSPECIFIED
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Date:November 2021
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:hypercaloric diet; hypothalamic; brainstem; functional connectivity
Event Title:32nd International Symposium on the Autonomic Nervous System
Event Location:Virtual Conference
Event Type:international Conference
Event Dates:04.-06. November 2021
Organizer:The American Autonomic Society
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:09 Nov 2021 12:33
Last Modified:09 Nov 2021 12:33

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