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Baroreflex Curve Fitting Using a WYSIWYG Boltzmann Sigmoidal Equation

Heusser, K. and Heusser, R. and Jordan, J. and Urechie, V. and Diedrich, A. and Tank, J. (2021) Baroreflex Curve Fitting Using a WYSIWYG Boltzmann Sigmoidal Equation. Frontiers in Neuroscience, 15, p. 697582. Frontiers Media S.A.. doi: 10.3389/fnins.2021.697582. ISSN 1662-4548.

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Official URL: http://dx.doi.org/10.3389/fnins.2021.697582


Arterial baroreflex assessment using vasoactive substances enables investigators to collect data pairs over a wide range of blood pressures and reflex reactions. These data pairs relate intervals between heartbeats or sympathetic neural activity to blood pressure values. In an X-Y plot the data points scatter around a sigmoidal curve. After fitting the parameters of a sigmoidal function to the data, the graph’s characteristics represent a rather comprehensive quantitative reflex description. Variants of the 4-parameter Boltzmann sigmoidal equation are widely used for curve fitting. Unfortunately, their ‘slope parameters’ do not correspond to the graph’s actual slope which complicates the analysis and bears the risk of misreporting. We propose a modified Boltzmann sigmoidal function with preserved goodness of fit whose parameters are one-to-one equivalent to the sigmoidal curve’s characteristics.

Item URL in elib:https://elib.dlr.de/144830/
Document Type:Article
Title:Baroreflex Curve Fitting Using a WYSIWYG Boltzmann Sigmoidal Equation
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Heusser, K.UNSPECIFIEDhttps://orcid.org/0000-0002-2571-5585UNSPECIFIED
Heusser, R.Immanuel Kant High School, Wilthen, GermanyUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Urechie, V.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University Medical Center, Nashville, TN, United StatesUNSPECIFIEDUNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIEDUNSPECIFIED
Tank, J.UNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Date:27 September 2021
Journal or Publication Title:Frontiers in Neuroscience
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:p. 697582
Publisher:Frontiers Media S.A.
Keywords:baroreflex curve; baroreflex gain; baroreflex sensitivity; RR interval;muscle sympathetic nerve activity; sigmoidal curve fitting; Boltzmann sigmoidal equation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:28 Oct 2021 15:39
Last Modified:28 Oct 2021 15:39

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