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The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies

Gratl, Alexandra and Wipper, Sabine and Frese, Jan Paul and Raude, Ben and Greiner, Andreas and Pesta, Dominik (2021) The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies. International Journal of Molecular Sciences, 22 (16), p. 8478. Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390/ijms22168478. ISSN 1661-6596.

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Official URL: http://dx.doi.org/10.3390/ijms22168478

Abstract

Recent evidence demonstrates an involvement of impaired mitochondrial function in peripheral arterial disease (PAD) development. Specific impairments have been assessed by different methodological in-vivo (near-infrared spectroscopy, 31P magnetic resonance spectroscopy), as well as in-vitro approaches (Western blotting of mitochondrial proteins and enzymes, assays of mitochondrial function and content). While effects differ with regard to disease severity, chronic malperfusion impacts subcellular energy homeostasis, and repeating cycles of ischemia and reperfusion contribute to PAD disease progression by increasing mitochondrial reactive oxygen species production and impairing mitochondrial function. With the leading clinical symptom of decreased walking capacity due to intermittent claudication, PAD patients suffer from a subsequent reduction of quality of life. Different treatment modalities, such as physical activity and revascularization procedures, can aid mitochondrial recovery. While the relevance of these modalities for mitochondrial functional recovery is still a matter of debate, recent research indicates the importance of revascularization procedures, with increased physical activity levels being a subordinate contributor, at least during mild stages of PAD. With an additional focus on the role of revascularization procedures on mitochondria and the identification of suitable mitochondrial markers in PAD, this review aims to critically evaluate the relevance of mitochondrial function in PAD development and progression

Item URL in elib:https://elib.dlr.de/144668/
Document Type:Article
Title:The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Gratl, AlexandraUNSPECIFIEDUNSPECIFIED
Wipper, SabineUNSPECIFIEDUNSPECIFIED
Frese, Jan PaulUNSPECIFIEDUNSPECIFIED
Raude, BenUNSPECIFIEDUNSPECIFIED
Greiner, AndreasUNSPECIFIEDUNSPECIFIED
Pesta, DominikInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Dominik.Pesta (at) dlr.dehttps://orcid.org/0000-0002-5089-3586
Date:6 August 2021
Journal or Publication Title:International Journal of Molecular Sciences
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:22
DOI :10.3390/ijms22168478
Page Range:p. 8478
Publisher:Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:1661-6596
Status:Published
Keywords:mitochondrial function; peripheral arterial disease; physical activity; mitochondrial recovery; revascularization
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Bone metabolism and structural adaptation
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Schönenberg, Sandra
Deposited On:28 Oct 2021 15:59
Last Modified:29 Oct 2021 11:31

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