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Flotation Restricted Environmental Stimulation Therapy for Chronic Pain

Loose, L. F. and Manuel, J. and Karst, M. and Schmidt, L. K. and Beissner, F. (2021) Flotation Restricted Environmental Stimulation Therapy for Chronic Pain. JAMA Network Open, 4 (5), e219627. American Medical Association. doi: 10.1001/jamanetworkopen.2021.9627. ISSN 2574-3805.

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Official URL: http://dx.doi.org/10.1001/jamanetworkopen.2021.9627

Abstract

Importance Flotation restricted environmental stimulation therapy (REST) is an emerging therapeutic intervention that, to our knowledge, has never been directly compared with an indistinguishable placebo in patients with chronic pain. Objective To determine whether 5 flotation-REST sessions alleviate chronic pain. Design, Setting, and Participants This single-blind, randomized clinical trial compared flotation-REST as an intervention for the treatment of chronic pain with indistinguishable placebo and wait-list control conditions at Hannover Medical School, Hannover, Germany. Men and women aged 18 to 75 years who had been diagnosed with chronic pain disorder with psychological and somatic factors (International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification, code F45.41) by physicians at the study center were randomly assigned to 1 of the 3 groups. Data were collected from June 26, 2018, to June 18, 2020. Interventions Patients in the intervention and placebo groups underwent 5 treatment sessions lasting 60 to 90 minutes, each session separated by 4 days. The placebo treatment was delivered in the same floating tank but controlled for effortless floating and environmental stimulus restriction. Patients in the wait-list control group did not receive any additional treatment but were asked to continue any ongoing treatments at the time of enrollment. Main Outcomes and Measures The primary outcome was a change in pain intensity 1 week after the last treatment session. The assessment was repeated at 12 and 24 weeks. Secondary outcomes included pain-related disability, pain area, pain widespreadness (number of body regions affected by pain), anxiety, depression, and quality of life, as well as several other short-term outcomes. Results A total of 99 patients (mean [SD] age, 51.7 [12.3] years; 80 women [81%]) were included in the study. No differences were found among the groups in the primary outcomes (mean [SD] change in maximum pain: −7.6 [19.7] for the intervention group, −5.8 [12.7] for the placebo group, and 0.4 [14.0] for the wait-list control group; mean [SD] change in mean pain: −2.1 [19.4] for the intervention group,−4.2 [16.2] for the placebo group, and 2.0 [12.6] for the wait-list control group). Long-term secondary outcomes did not show significant differences. In the short term, patients in the intervention group showed significant improvements in pain intensity (−17.0 [17.1]; P < .001), relaxation (23.9 [22.6]; P < .001), anxiety (−10.1 [8.4]; P < .001), pain area (−3.6% [7.4%]; P < .001), and widespreadness (−2.0 [3.0]; P < .001), and similar changes where observed in the placebo group. Conclusions and Relevance Patients with chronic pain experienced no long-term benefits from the 5 flotation-REST interventions. Clinically relevant short-term changes in pain in the placebo group suggest that improvements may not be caused by environmental stimulus restriction or effortless floating as previously thought.

Item URL in elib:https://elib.dlr.de/144596/
Document Type:Article
Title:Flotation Restricted Environmental Stimulation Therapy for Chronic Pain
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Loose, L. F.Somatosensory and Autonomic Therapy Research, Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Manuel, J.Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany and Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Karst, M.Department of Anesthesiology and Intensive Care Medicine, Pain Clinic, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Schmidt, L. K.Somatosensory and Autonomic Therapy Research, Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Beissner, F.Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Date:May 2021
Journal or Publication Title:JAMA Network Open
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:4
DOI :10.1001/jamanetworkopen.2021.9627
Page Range:e219627
Publisher:American Medical Association
ISSN:2574-3805
Status:Published
Keywords:Chronic Pain; Therapy; stimulation; flotation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:21 Oct 2021 12:51
Last Modified:21 Oct 2021 12:51

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