elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Natriuretic Peptides and Risk of Type 2 Diabetes: Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium

Sujana, C. and Salomaa, V. and Kee, F. and Costanzo, S. and Söderberg, S. and Jordan, J. and Jousilahti, P. and Neville, C. and Iacoviello, L. and Oskarsson, V. and Westermann, D. and Koenig, W. and Kuulasmaa, K. and Reinikainen, J. and Blankenberg, S. and Zeller, T. and Herder, C. and Mansmann, U. and Peters, A. and Thorand, B. (2021) Natriuretic Peptides and Risk of Type 2 Diabetes: Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium. Diabetes Care, 44 (11), pp. 2527-2535. American Diabetes Association. doi: 10.2337/dc21-0811. ISSN 1935-5548.

Full text not available from this repository.

Official URL: http://dx.doi.org/10.2337/dc21-0811

Abstract

Objective: Natriuretic peptide (NP) concentrations are increased in cardiovascular diseases (CVDs) but are associated with a lower diabetes risk. We investigated associations of N-terminal pro-B-type NP (NT-proBNP) and midregional proatrial NP (MR-proANP) with incident type 2 diabetes stratified by the presence of CVD. Research design and methods: Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium, we included 45,477 participants with NT-proBNP measurements (1,707 developed type 2 diabetes over 6.5 years of median follow-up; among these, 209 had CVD at baseline) and 11,537 participants with MR-proANP measurements (857 developed type 2 diabetes over 13.8 years of median follow-up; among these, 106 had CVD at baseline). The associations were estimated using multivariable Cox regression models. Results: Both NPs were inversely associated with incident type 2 diabetes (hazard ratios [95% CI] per 1-SD increase of log NP: 0.84 [0.79; 0.89] for NT-proBNP and 0.77 [0.71; 0.83] for MR-proANP). The inverse association between NT-proBNP and type 2 diabetes was significant in individuals without CVD but not in individuals with CVD (0.81 [0.76; 0.86] vs. 1.04 [0.90; 1.19]; P multiplicative interaction = 0.001). There was no significant difference in the association of MR-proANP with type 2 diabetes between individuals without and with CVD (0.75 [0.69; 0.82] vs. 0.81 [0.66; 0.99]; P multiplicative interaction = 0.236). Conclusions: NT-proBNP and MR-proANP are inversely associated with incident type 2 diabetes. However, the inverse association of NT-proBNP seems to be modified by the presence of CVD. Further investigations are warranted to confirm our findings and to investigate the underlying mechanisms.

Item URL in elib:https://elib.dlr.de/144558/
Document Type:Article
Title:Natriuretic Peptides and Risk of Type 2 Diabetes: Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Sujana, C.Institute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germanyhttps://orcid.org/0000-0002-0663-2557UNSPECIFIED
Salomaa, V.Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FinlandUNSPECIFIEDUNSPECIFIED
Kee, F.Centre for Public Health, Queens University of Belfast, Belfast, Northern Ireland, U.KUNSPECIFIEDUNSPECIFIED
Costanzo, S.Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, ItalyUNSPECIFIEDUNSPECIFIED
Söderberg, S.Department of Public Health and Clinical Medicine, Umeå University, Umeå, SwedenUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Jousilahti, P.Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FinlandUNSPECIFIEDUNSPECIFIED
Neville, C.Centre for Public Health, Queens University of Belfast, Belfast, Northern Ireland, U.KUNSPECIFIEDUNSPECIFIED
Iacoviello, L.Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, ItalyUNSPECIFIEDUNSPECIFIED
Oskarsson, V.Department of Public Health and Clinical Medicine, Umeå University, Umeå, SwedenUNSPECIFIEDUNSPECIFIED
Westermann, D.Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, GermanyUNSPECIFIEDUNSPECIFIED
Koenig, W.Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, GermanyUNSPECIFIEDUNSPECIFIED
Kuulasmaa, K.Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FinlandUNSPECIFIEDUNSPECIFIED
Reinikainen, J.Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FinlandUNSPECIFIEDUNSPECIFIED
Blankenberg, S.Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, GermanyUNSPECIFIEDUNSPECIFIED
Zeller, T.Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, GermanyUNSPECIFIEDUNSPECIFIED
Herder, C.Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, GermanyUNSPECIFIEDUNSPECIFIED
Mansmann, U.Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-Universität, Munich, GermanyUNSPECIFIEDUNSPECIFIED
Peters, A.Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyUNSPECIFIEDUNSPECIFIED
Thorand, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date:September 2021
Journal or Publication Title:Diabetes Care
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:44
DOI:10.2337/dc21-0811
Page Range:pp. 2527-2535
Publisher:American Diabetes Association
ISSN:1935-5548
Status:Published
Keywords:Type 2 Diabetes; Biomarkers; Cardiovascular; Natriuretic Peptides
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:21 Oct 2021 11:46
Last Modified:21 Oct 2021 11:46

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Website and database design: Copyright © German Aerospace Center (DLR). All rights reserved.