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Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging

Möstl, S. and Orter, S. and Hoffmann, F. and Bachler, M. and Hametner, B. and Wassertheurer, S. and Rabineau, J. and Mulder, E. and Johannes, B. and Jordan, J. and Tank, J. (2021) Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging. Frontiers in Physiology, 12, p. 685473. Frontiers Media S.A. doi: 10.3389/fphys.2021.685473. ISSN 1664-042X.

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Official URL: http://dx.doi.org/10.3389/fphys.2021.685473

Abstract

Background Cardiovascular risk may be increased in astronauts after long term space flights based on biomarkers indicating premature vascular aging. We tested the hypothesis that 60 days of strict 6° head down tilt bed rest (HDTBR), an established space analog, promotes vascular stiffening and that artificial gravity training ameliorates the response. Methods We studied 24 healthy participants (8 women, 24–55 years, BMI = 24.3 ± 2.1 kg/m2) before and at the end of 60 days HDTBR. 16 subjects were assigned to daily artificial gravity. We applied echocardiography to measure stroke volume and isovolumetric contraction time (ICT), calculated aortic compliance (stroke volume/aortic pulse pressure), and assessed aortic distensibility by MRI. Furthermore, we measured brachial-femoral pulse wave velocity (bfPWV) and pulse wave arrival times (PAT) in different vascular beds by blood pressure cuffs and photoplethysmography. We corrected PAT for ICT (cPAT). Results In the pooled sample, diastolic blood pressure (+8 ± 7 mmHg, p < 0.001), heart rate (+7 ± 9 bpm, p = 0.002) and ICT (+8 ± 13 ms, p = 0.036) increased during HDTBR. Stroke volume decreased by 14 ± 15 ml (p = 0.001). bfPWV, aortic compliance, aortic distensibility and all cPAT remained unchanged. Aortic area tended to increase (p = 0.05). None of the parameters showed significant interaction between HDTBR and artificial gravity training. Conclusion 60 days HDTBR, while producing cardiovascular deconditioning and cephalad fluid shifts akin to weightlessness, did not worsen vascular stiffness. Artificial gravity training did not modulate the response

Item URL in elib:https://elib.dlr.de/144550/
Document Type:Article
Title:Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Möstl, S.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Stefan.moestl (at) dlr.de.UNSPECIFIED
Orter, S.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIED
Bachler, M.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIED
Hametner, B.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIED
Wassertheurer, S.Center for Health and Bioresources, AIT Austrian Institute of Technology, Vienna, AustriaUNSPECIFIED
Rabineau, J.LPHYS, Université Libre de Bruxelles, Brussels, BelgiumUNSPECIFIED
Mulder, E.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Johannes, B.Department of Muscle and Bone Metabolism, German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Date:28 May 2021
Journal or Publication Title:Frontiers in Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:12
DOI :10.3389/fphys.2021.685473
Page Range:p. 685473
Publisher:Frontiers Media S.A
ISSN:1664-042X
Status:Published
Keywords:AGBRESA; aortic distensibility; arterial stiffness; artificial gravity; isovolumetric contraction time; pre-ejection period; pulse wave arrival time; pulse wave velocity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain, R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:21 Oct 2021 11:25
Last Modified:21 Oct 2021 17:40

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