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Medullary and Hypothalamic Functional Magnetic Imaging During Acute Hypoxia in Tracing Human Peripheral Chemoreflex Responses

Gerlach, D.A. and Manuel, J. and Hoff, A. and Kronsbein, H. and Hoffmann, F. and Heusser, Karsten and Ehmke, H. and Jordan, J. and Tank, J. and Beissner, F. (2021) Medullary and Hypothalamic Functional Magnetic Imaging During Acute Hypoxia in Tracing Human Peripheral Chemoreflex Responses. Hypertension, 77 (4), pp. 1372-1382. American Heart Association, Inc.. doi: 10.1161/HYPERTENSIONAHA.120.16385. ISSN 0194-911X.

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Official URL: http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16385

Abstract

Hypoxia-sensitive peripheral carotid chemoreceptors, which regulate sympathetic outflow from the brain stem, are promising antihypertensive treatment targets. However, the central nervous pathways integrating human peripheral chemoreflexes are poorly understood. We combined high-resolution functional magnetic resonance imaging with physiological profiling to elucidate hypothalamic and medullary responses to acute hypoxia. We exposed 12 healthy men (29.7±6.6 years) to 5 hypoxic episodes each by breathing 10% oxygen for 180 seconds followed by 90 seconds of normoxia during high-resolution subcortical functional magnetic resonance imaging. We recorded beat-by-beat finger blood pressure, ECG, and peripheral oxygen saturation (Spo2). We analyzed functional magnetic resonance imaging data through independent component analysis, correlation with systolic blood pressure and Spo2, and functional connectivity analysis by dual regression. On average Spo2 decreased by 12±3% (P<0.01) during hypoxia while heart rate increased by 3±7 bpm (P<0.01). Systolic blood pressure was unchanged. Brain stem-centered analyses revealed 5 distinct hypoxia-responsive regions around the nucleus of the solitary tract, nucleus ambiguus/intermediate reticular nucleus, dorsal motor nucleus of the vagal nerve, spinal trigeminal nucleus, and inferior olivary nucleus. Hypothalamus-centered analysis revealed 3 such regions around the arcuate nucleus, anterior hypothalamic area/lateral hypothalamic area, and paraventricular nucleus. During hypoxia, these regions showed altered functional connectivity with various medullary and hypothalamic areas. We conclude that high-resolution functional magnetic resonance imaging reveals subcortical systems engaged by acute hypoxia, which likely correspond to the peripheral chemoreceptor pathway. Our methodology may have utility in studying peripheral chemoreflex contributions to cardiovascular disease and responses to peripheral chemoreceptor modulation

Item URL in elib:https://elib.dlr.de/144544/
Document Type:Article
Title:Medullary and Hypothalamic Functional Magnetic Imaging During Acute Hypoxia in Tracing Human Peripheral Chemoreflex Responses
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Gerlach, D.A.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0001-7044-6065
Manuel, J.Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Hoff, A.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Kronsbein, H.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Heusser, KarstenInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Ehmke, H.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Beissner, F.Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Date:1 March 2021
Journal or Publication Title:Hypertension
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:77
DOI :10.1161/HYPERTENSIONAHA.120.16385
Page Range:pp. 1372-1382
Publisher:American Heart Association, Inc.
ISSN:0194-911X
Status:Published
Keywords:blood pressure; brain stem; hypothalamus; hypoxia; magnetic resonance imaging
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:21 Oct 2021 16:26
Last Modified:21 Oct 2021 17:34

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