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Altered gravity exposure triggers autophagy-dependent morphological alterations of C2C12 murine muscle cells

Meerholz, Zoe (2021) Altered gravity exposure triggers autophagy-dependent morphological alterations of C2C12 murine muscle cells. Bachelor's, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.

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Abstract

During space missions, muscles are heavily weakened and start to deteriorate, as microgravity makes any kind of exercise physically undemanding. This kind of loss in muscle mass, called space induced muscle atrophy, is of growing interest since it is one of the limiting factors of long-duration space missions. Through researching the changes in muscles which cause this rapid loss, staying in space for a longer period will not be so far away anymore. Autophagy plays an important role during muscle atrophy as it is used to degrade cytosolic components. One autophagy pathway which is crucial for muscle maintenance is the chaperone-assisted selective autophagy (CASA) pathway. For this reason, it is of rising interest to investigate whether CASA plays a role in space induced muscle atrophy. This study shows that CASA is affected during a 24-hour exposure to simulated microgravity, since the protein level as well as the protein turnover change upon simulated microgravity exposure. These results indicate that CASA could possibly be influencing muscle atrophy. In addition, there are first indications that CASA could be involved in a readaptation process, since it could be shown that the protein level changed after the reintroduction to Earth gravity. These new insights contribute to understanding what could cause space induced muscle atrophy. Therefore, it is of growing need to further investigate CASAs role in this disease to find possible countermeasures which could possibly stop muscle atrophy from ever occurring under the absence of gravity.

Item URL in elib:https://elib.dlr.de/144289/
Document Type:Thesis (Bachelor's)
Additional Information:First Supervisor: Prof. Dr. rer. nat. Jörg Höhfeld, University Bonn, Institute for Cell biology; Second Supervisor: Dr. Christian Liemersdorf, German Aerospace Center (DLR), Institute of Aerospace Medicine, Department of Gravitational Biology
Title:Altered gravity exposure triggers autophagy-dependent morphological alterations of C2C12 murine muscle cells
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Meerholz, ZoeGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Gravitational Biology, CologneUNSPECIFIEDUNSPECIFIED
Date:September 2021
Refereed publication:Yes
Open Access:No
Number of Pages:80
Status:Published
Keywords:muscle atrophy, CASA (chaperone-assisted selective autophagy), autophagy, simulated microgravity, long-duration space mission
Institution:Rheinische Friedrich-Wilhelms-University, Bonn, Germany
Department:Faculty of Mathematics and Natural Sciences, Biology
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - NeuroSpace
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Chiodo, Annette
Deposited On:04 Nov 2021 09:08
Last Modified:04 Nov 2021 09:08

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