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Femoral anteversion (FNA) in individuals with X-linked hypophosphatemia (XLH)

Scorcelletti, Matteo und Kara, Serhan und Zange, Jochen und Rittweger, Jörn (2021) Femoral anteversion (FNA) in individuals with X-linked hypophosphatemia (XLH). Science Direct. 48th European Calcified Tissue Society Congress ECTS 2021, 2021-05-19 - 2021-06-18, The #ECTS 2021 Digital Congress will be divided in two parts: a Live Prime Time on 6-8 May 2021 and 5 days of ECTS@Home on 19-20 May, 10-11 June and 18 June 2021. doi: 10.1016/j.bonr.2021.100785.

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Background/Introduction: XLH is a rare genetic condition which affects phosphate metabolism, resulting in osteomalacia. Individuals with XLH are also at risk of lower limb deformities and early onset of hip osteoarthritis. These two factors may be linked, as abnormal FNA (femoral torsion) is a risk factor for hip osteoarthritis. The contributions of regional femoral torsion e.g. intertrochanteric torsion (ITT), shaft torsion (ST) and condylar torsion(CT) to FNA differ between clinical groups and are important when planning femoral osteotomies to correct FNA. Purpose: This study aimed to compare FNA and regional femoral torsion of the femur between adults with XLH and controls. Methods: 13 individuals with XLH (5 male, age 49±9y) and 12 age, sex and weight-matched control participants (7 male, age 49±8y) were recruited following ethical approval and informed consent. Magnetic resonance imaging (MRI) scans of the femur were obtained, from which FNA, ITT, ST and CT were measured. Data were normally distributed, therefore group differences were assessed using t-tests. Results: FNA was 29° lower in individuals with XLH than controls (pb0.005). This resulted mainly from lower ITT (pb0.001) and in part CT (pb0.05) whereas ST was similar in the two groups (Fig. 1). Conclusion(s): We observed differences in FNA and regionspecific femoral torsion in individuals with XLH compared to controls. These differences may contribute to clinical problems such as hip osteoarthritis common in XLH. Information on region-specific differences may be useful in planning corrective surgeries. Future work should examine how pharmacological and other interventions in this group affect FNA.

elib-URL des Eintrags:https://elib.dlr.de/143576/
Dokumentart:Konferenzbeitrag (Vortrag)
Titel:Femoral anteversion (FNA) in individuals with X-linked hypophosphatemia (XLH)
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Scorcelletti, MatteoDepartment of Life Sciences, Research Centre for Musculoskeletal Science & Sports Medicine, Manchester Metropolitan University, Manchester, UKhttps://orcid.org/0000-0003-0186-1008NICHT SPEZIFIZIERT
Kara, SerhanSerhan.Kara (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952133724708
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963NICHT SPEZIFIZIERT
Datum:April 2021
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Band:14
DOI:10.1016/j.bonr.2021.100785
Seitenbereich:Seite 100783
Verlag:Science Direct
Name der Reihe:Elsevier Bone Reports
Status:veröffentlicht
Stichwörter:bone, fermoral antevervion, magnetic resonance imaging, X-linked hypophosphatemia
Veranstaltungstitel:48th European Calcified Tissue Society Congress ECTS 2021
Veranstaltungsort:The #ECTS 2021 Digital Congress will be divided in two parts: a Live Prime Time on 6-8 May 2021 and 5 days of ECTS@Home on 19-20 May, 10-11 June and 18 June 2021
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:19 Mai 2021
Veranstaltungsende:18 Juni 2021
Veranstalter :European Calcified Tissue Society
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Langzeitfolgen von körperlicher Inaktivität versus Aktivität
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Muskel- und Knochenstoffwechsel
Hinterlegt von: Zange, Dr.rer.nat. Jochen
Hinterlegt am:24 Aug 2021 11:30
Letzte Änderung:24 Apr 2024 20:43

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