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Femoral anteversion (FNA) in individuals with X-linked hypophosphatemia (XLH)

Scorcelletti, Matteo and Kara, Serhan and Zange, Jochen and Rittweger, Jörn (2021) Femoral anteversion (FNA) in individuals with X-linked hypophosphatemia (XLH). Science Direct. 48th European Calcified Tissue Society Congress ECTS 2021, 19–20 May, 10–11 June and on 18 June 2021, digital. doi: 10.1016/j.bonr.2021.100785.

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Abstract

Background/Introduction: XLH is a rare genetic condition which affects phosphate metabolism, resulting in osteomalacia. Individuals with XLH are also at risk of lower limb deformities and early onset of hip osteoarthritis. These two factors may be linked, as abnormal FNA (femoral torsion) is a risk factor for hip osteoarthritis. The contributions of regional femoral torsion e.g. intertrochanteric torsion (ITT), shaft torsion (ST) and condylar torsion(CT) to FNA differ between clinical groups and are important when planning femoral osteotomies to correct FNA. Purpose: This study aimed to compare FNA and regional femoral torsion of the femur between adults with XLH and controls. Methods: 13 individuals with XLH (5 male, age 49±9y) and 12 age, sex and weight-matched control participants (7 male, age 49±8y) were recruited following ethical approval and informed consent. Magnetic resonance imaging (MRI) scans of the femur were obtained, from which FNA, ITT, ST and CT were measured. Data were normally distributed, therefore group differences were assessed using t-tests. Results: FNA was 29° lower in individuals with XLH than controls (pb0.005). This resulted mainly from lower ITT (pb0.001) and in part CT (pb0.05) whereas ST was similar in the two groups (Fig. 1). Conclusion(s): We observed differences in FNA and regionspecific femoral torsion in individuals with XLH compared to controls. These differences may contribute to clinical problems such as hip osteoarthritis common in XLH. Information on region-specific differences may be useful in planning corrective surgeries. Future work should examine how pharmacological and other interventions in this group affect FNA.

Item URL in elib:https://elib.dlr.de/143576/
Document Type:Conference or Workshop Item (Speech)
Title:Femoral anteversion (FNA) in individuals with X-linked hypophosphatemia (XLH)
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Scorcelletti, MatteoDepartment of Life Sciences, Research Centre for Musculoskeletal Science & Sports Medicine, Manchester Metropolitan University, Manchester, UKhttps://orcid.org/0000-0003-0186-1008
Kara, SerhanSerhan.Kara (at) dlr.deUNSPECIFIED
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Date:April 2021
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Volume:14
DOI :10.1016/j.bonr.2021.100785
Page Range:p. 100783
Publisher:Science Direct
Series Name:Elsevier Bone Reports
Status:Published
Keywords:bone, fermoral antevervion, magnetic resonance imaging, X-linked hypophosphatemia
Event Title:48th European Calcified Tissue Society Congress ECTS 2021
Event Location:digital
Event Type:international Conference
Event Dates:19–20 May, 10–11 June and on 18 June 2021
Organizer:European Calcified Tissue Society
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Long-term effects of physical inactivity versus activity
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:24 Aug 2021 11:30
Last Modified:24 Aug 2021 11:30

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