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Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day headdown tilt bed rest

De Martino, Enrico and Hides, Julie and Elliott, James M. and Hoggarth, Mark and Zange, Jochen and Lindsay, Kirty and Debuse, Dorothée and Winnard, Andrew and Beard, David and Cook, Jonathan A. and Salomoni, Sauro E. and Weber, Tobias and Scott, Jonathan and Hodges, Paul W. and Caplan, Nick (2021) Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day headdown tilt bed rest. Journal of Applied Physiology, 131 (1), pp. 356-368. American Physiological Society. doi: 10.1152/japplphysiol.00990.2020. ISSN 8750-7587.

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Abstract

Exposure to axial unloading induces adaptations in paraspinal muscles, as shown after spaceflights. This study investigated whether daily exposure to artificial gravity (AG) mitigated lumbar spine flattening and muscle atrophy associated with 60-day head-down tilt (HDT) bed rest (Earth-based space analog). Twenty-four healthy individuals participated in the study: 8 received 30-min continuous AG; 8 received 6 x 5-min AG interspersed with rest periods; and 8 received no AG exposure (control group). Magnetic resonance imaging (MRI) of the lumbopelvic region was conducted at baseline (BDC) and at day 59 of HDT (HDT59). Longitudinal relaxation time (T1)-weighted images were used to assess morphology of the lumbar spine (spinal length, intervertebral disk angles, disk area) and volumes of the lumbar multifidus (LM), lumbar erector spinae (LES), quadratus lumborum (QL), and psoas major (PM) muscles from L1/L2 to L5/S1 vertebral levels. A chemical shift-based two-point lipid/water Dixon sequence was used to evaluate muscle composition. Results showed that spinal length and disk area increased (P < 0.05); intervertebral disk angles (P < 0.05) and muscle volumes of LM, LES, and QL reduced (P < 0.01); and lipid-to-water ratio for the LM and LES muscles increased (P < 0.01) after HDT59 in all groups. Neither of the AG protocols mitigated the lumbar spinae deconditioning induced by HDT bed rest. The increase in lipid-to-water ratio in LM and LES muscles indicates an increased relative intramuscular lipid concentration. Altered muscle composition in atrophied muscles may impair lumbar spine function after body unloading, which could increase injury risk to vulnerable soft tissues. This relationship needs further investigation.

Item URL in elib:https://elib.dlr.de/143575/
Document Type:Article
Title:Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day headdown tilt bed rest
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
De Martino, EnricoNorthumbria University, Newcastle, UKhttps://orcid.org/0000-0003-3211-3723
Hides, JulieJulie.Hides (at) acu.edu.auhttps://orcid.org/0000-0002-1830-8121
Elliott, James M.University of Sydney, Sydney, Australiahttps://orcid.org/0000-0003-4821-6831
Hoggarth, Markmark.hoggarth (at) northwestern.eduhttps://orcid.org/0000-0001-6516-5840
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Lindsay, KirtyNorthumbria University, Newcastle, UKUNSPECIFIED
Debuse, DorothéeNorthumbria University, Newcastle, UKUNSPECIFIED
Winnard, AndrewNorthumbria University, Newcastle, UKUNSPECIFIED
Beard, DavidUniversity of Oxford, UKhttps://orcid.org/0000-0001-7884-6389
Cook, Jonathan A.University of Oxford, UKhttps://orcid.org/0000-0002-4156-6989
Salomoni, Sauro E.University of Queenslad: Brisbane, Queensland, AUhttps://orcid.org/0000-0001-7616-9003
Weber, TobiasEuropean Astronaut Center, Cologne, GermanyUNSPECIFIED
Scott, JonathanJonathan.Scott (at) wylelabs.deUNSPECIFIED
Hodges, Paul W.University of Queensland, Brisbane, Queensland, Australiahttps://orcid.org/0000-0002-1206-9107
Caplan, Nicknick.caplan (at) northumbria.ac.ukUNSPECIFIED
Date:3 June 2021
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:131
DOI :10.1152/japplphysiol.00990.2020
Page Range:pp. 356-368
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:AGBRESA; immobilization; magnetic resonance imaging; paraspinal muscles; short-arm centrifugation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Long-term effects of physical inactivity versus activity
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:24 Aug 2021 11:26
Last Modified:24 Aug 2021 11:26

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