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Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day headdown tilt bed rest

De Martino, Enrico and Hides, Julie and Elliott, James M. and Hoggarth, Mark and Zange, Jochen and Lindsay, Kirty and Debuse, Dorothée and Winnard, Andrew and Beard, David and Cook, Jonathan A. and Salomoni, Sauro E. and Weber, Tobias and Scott, Jonathan and Hodges, Paul W. and Caplan, Nick (2021) Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day headdown tilt bed rest. Journal of Applied Physiology, 131 (1), pp. 356-368. American Physiological Society. doi: 10.1152/japplphysiol.00990.2020. ISSN 8750-7587.

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Exposure to axial unloading induces adaptations in paraspinal muscles, as shown after spaceflights. This study investigated whether daily exposure to artificial gravity (AG) mitigated lumbar spine flattening and muscle atrophy associated with 60-day head-down tilt (HDT) bed rest (Earth-based space analog). Twenty-four healthy individuals participated in the study: 8 received 30-min continuous AG; 8 received 6 x 5-min AG interspersed with rest periods; and 8 received no AG exposure (control group). Magnetic resonance imaging (MRI) of the lumbopelvic region was conducted at baseline (BDC) and at day 59 of HDT (HDT59). Longitudinal relaxation time (T1)-weighted images were used to assess morphology of the lumbar spine (spinal length, intervertebral disk angles, disk area) and volumes of the lumbar multifidus (LM), lumbar erector spinae (LES), quadratus lumborum (QL), and psoas major (PM) muscles from L1/L2 to L5/S1 vertebral levels. A chemical shift-based two-point lipid/water Dixon sequence was used to evaluate muscle composition. Results showed that spinal length and disk area increased (P < 0.05); intervertebral disk angles (P < 0.05) and muscle volumes of LM, LES, and QL reduced (P < 0.01); and lipid-to-water ratio for the LM and LES muscles increased (P < 0.01) after HDT59 in all groups. Neither of the AG protocols mitigated the lumbar spinae deconditioning induced by HDT bed rest. The increase in lipid-to-water ratio in LM and LES muscles indicates an increased relative intramuscular lipid concentration. Altered muscle composition in atrophied muscles may impair lumbar spine function after body unloading, which could increase injury risk to vulnerable soft tissues. This relationship needs further investigation.

Item URL in elib:https://elib.dlr.de/143575/
Document Type:Article
Title:Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day headdown tilt bed rest
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
De Martino, EnricoNorthumbria University, Newcastle, UKhttps://orcid.org/0000-0003-3211-3723UNSPECIFIED
Hides, JulieUNSPECIFIEDhttps://orcid.org/0000-0002-1830-8121UNSPECIFIED
Elliott, James M.University of Sydney, Sydney, Australiahttps://orcid.org/0000-0003-4821-6831UNSPECIFIED
Hoggarth, MarkUNSPECIFIEDhttps://orcid.org/0000-0001-6516-5840UNSPECIFIED
Zange, JochenUNSPECIFIEDhttps://orcid.org/0000-0003-1822-0952133724705
Lindsay, KirtyNorthumbria University, Newcastle, UKUNSPECIFIEDUNSPECIFIED
Debuse, DorothéeNorthumbria University, Newcastle, UKUNSPECIFIEDUNSPECIFIED
Winnard, AndrewNorthumbria University, Newcastle, UKUNSPECIFIEDUNSPECIFIED
Beard, DavidUniversity of Oxford, UKhttps://orcid.org/0000-0001-7884-6389UNSPECIFIED
Cook, Jonathan A.University of Oxford, UKhttps://orcid.org/0000-0002-4156-6989UNSPECIFIED
Salomoni, Sauro E.University of Queenslad: Brisbane, Queensland, AUhttps://orcid.org/0000-0001-7616-9003UNSPECIFIED
Weber, TobiasEuropean Astronaut Center, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Hodges, Paul W.University of Queensland, Brisbane, Queensland, Australiahttps://orcid.org/0000-0002-1206-9107UNSPECIFIED
Date:3 June 2021
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:pp. 356-368
Publisher:American Physiological Society
Keywords:AGBRESA; immobilization; magnetic resonance imaging; paraspinal muscles; short-arm centrifugation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Long-term effects of physical inactivity versus activity
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:24 Aug 2021 11:26
Last Modified:28 Jun 2023 14:01

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