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Daily 30‑min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT

Kramer, Andreas and Venegas-Carro, Maria and Zange, Jochen and Sies, Wolfram and Maffiuletti, Nicola A. and Gruber, Markus and Degens, Hans and Moreno-Villanueva, Maria (2021) Daily 30‑min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT. European Journal of Applied Physiology, 121, pp. 2015-2026. Springer. doi: 10.1007/s00421-021-04673-w. ISSN 1439-6319.

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Abstract

Purpose: Spaceflight impairs physical capacity. Here we assessed the protective effect of artificial gravity (AG) on aerobic exercise capacity and muscle function during bed rest, a spaceflight analogue. Methods: 24 participants (33 ± 9 years, 175 ± 9 cm, 74 ± 10 kg, 8 women) were randomly allocated to one of three groups: continuous AG (cAG), intermittent AG (iAG) or control (CTRL). All participants were subjected to 60 days of six-degree head-down tilt bed rest, and subjects of the intervention groups completed 30 min of centrifugation per day: cAG continuously and iAG for 6×5 min, with an acceleration of 1g at the center of mass. Physical capacity was assessed before and after bed rest via maximal voluntary contractions, cycling spiroergometry, and countermovement jumps. Results: AG had no significant effect on aerobic exercise capacity, flexor muscle function and isometric knee extension strength or rate of force development (RFD). However, AG mitigated the effects of bed rest on jumping power (group * time interaction of the rmANOVA p < 0.001; iAG − 25%, cAG − 26%, CTRL − 33%), plantar flexion strength (group * time p=0.003; iAG −35%, cAG −31%, CTRL −48%) and plantar flexion RFD (group*time p=0.020; iAG −28%, cAG −12%, CTRL − 40%). Women showed more pronounced losses than men in jumping power (p <0.001) and knee extension strength (p = 0.010). Conclusion: The AG protocols were not suitable to maintain aerobic exercise capacity, probably due to the very low cardiorespiratory demand of this intervention. However, they mitigated some losses in muscle function, potentially due to the low-intensity muscle contractions during centrifugation used to avoid presyncope.

Item URL in elib:https://elib.dlr.de/143574/
Document Type:Article
Title:Daily 30‑min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Kramer, AndreasNeuromechanics Research Group, Sport Sciences, University of Konstanz, Konstanz, GermanyUNSPECIFIED
Venegas-Carro, MariaDepartment of Sport Science, University of Konstanz, Konstanz, Germanyhttps://orcid.org/0000-0002-7156-4810
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Sies, Wolframwolfram.sies (at) dlr.deUNSPECIFIED
Maffiuletti, Nicola A.Schulthess Clinic, Zürich, CHhttps://orcid.org/0000-0001-5670-286X
Gruber, MarkusDepartment of Sport Science, University of Konstanz, Konstanz, Germanyhttps://orcid.org/0000-0002-0233-3912
Degens, HansManchester Metropolitan Universityhttps://orcid.org/0000-0001-7399-4841
Moreno-Villanueva, MariaDepartment of Biology, University of Konstanz, Konstanz, Germanyhttps://orcid.org/0000-0002-7143-0871
Date:3 April 2021
Journal or Publication Title:European Journal of Applied Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:121
DOI :10.1007/s00421-021-04673-w
Page Range:pp. 2015-2026
Publisher:Springer
ISSN:1439-6319
Status:Published
Keywords:Countermeasure, Astronaut training, Artificial gravity, Physical performance, Physical inactivity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Long-term effects of physical inactivity versus activity
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:24 Aug 2021 11:12
Last Modified:24 Aug 2021 11:12

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