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Quantitative assessment of the lumbar intervertebral disc via T2 shows excellent long-term reliability

Belavy, Daniel L. and Owen, Patrick J. and Armbrecht, Gabriele and Bansmann, Martin and Zange, Jochen and Ling, Yuan and Pohle-Fröhlich, Regina and Felsenberg, Dieter (2021) Quantitative assessment of the lumbar intervertebral disc via T2 shows excellent long-term reliability. PLoS One, 16 (4), e0249855. Public Library of Science (PLoS). doi: 10.1371/journal.pone.0249855. ISSN 1932-6203.

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Abstract

Methodologies for the quantitative assessment of the spine tissues, in particular the intervertebral disc (IVD), have not been well established in terms of long-term reliability. This is required for designing prospective studies. 1H water T2 in the IVD (“T2”) has attained wider use in assessment of the lumbar intervertebral discs via magnetic resonance imaging. The reliability of IVD T2 measurements are yet to be established. IVD T2 was assessed nine times at regular intervals over 368 days on six anatomical slices centred at the lumbar spine using a spin-echo multi-echo sequence in 12 men. To assess repeatability, intra-class correlation co-efficients (ICCs), standard error of the measurement, minimal detectable difference and co-efficients of variation (CVs) were calculated along with their 95% confidence intervals. Bland-Altman analysis was also performed. ICCs were above 0.93, with the exception of nuclear T2 at L5/S1, where the ICC was 0.88. CVs of the central-slice nucleus sub-region ranged from 4.3% (average of all levels) to 10.1% for L5/S1 and between 2.2% to 3.2% for whole IVD T2 (1.8% for the average of all levels). Averaging between vertebral levels improved reliability. Reliability of measurements was least at L5/S1. ICCs of degenerated IVDs were lower. Test-retest reliability was excellent for whole IVD and good to excellent for IVD subregions. The findings help to establish the long-term repeatability of lumbar IVD T2 for the implementation of prospective studies and determination of significant changes within individuals.

Item URL in elib:https://elib.dlr.de/143572/
Document Type:Article
Title:Quantitative assessment of the lumbar intervertebral disc via T2 shows excellent long-term reliability
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Belavy, Daniel L.Deakin University, Australiahttps://orcid.org/0000-0002-9307-832X
Owen, Patrick J.Deakin University, Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Geelong, Victoria, Australiahttps://orcid.org/0000-0003-3924-9375
Armbrecht, GabrieleCharité Campus Benjamin Franklinhttps://orcid.org/0000-0002-6578-338X
Bansmann, MartinKrankenhaus PorzUNSPECIFIED
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Ling, YuanImaging at Olympic Park, Melburne, AustraliaUNSPECIFIED
Pohle-Fröhlich, ReginaHochschule Niederrhein, Institute for Pattern Recognition, KrefeldUNSPECIFIED
Felsenberg, DieterCharité University Medicine BerlinUNSPECIFIED
Date:14 April 2021
Journal or Publication Title:PLoS One
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:16
DOI :10.1371/journal.pone.0249855
Page Range:e0249855
Publisher:Public Library of Science (PLoS)
ISSN:1932-6203
Status:Published
Keywords:intervetebral disk, lumbar spine, magnetic resonance imaging, reliability, T2
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Long-term effects of physical inactivity versus activity
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:24 Aug 2021 10:43
Last Modified:24 Aug 2021 10:52

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