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Effects of Head-Down Tilt Bed Rest Plus Elevated CO₂ on Cognitive Performance

Basner, M. and Stahn, A.C. and Nasrini, J. and Dinges, D.F. and Moore, T.M. and Gur, R.C. and Mühl, C. and Macias, B.R. and Laurie, S.S. (2021) Effects of Head-Down Tilt Bed Rest Plus Elevated CO₂ on Cognitive Performance. Journal of Applied Physiology, 130 (4), pp. 1235-1246. American Physiological Society. doi: 10.1152/japplphysiol.00865.2020. ISSN 8750-7587.

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Official URL: https://doi.org/10.1152/japplphysiol.00865.2020

Abstract

Microgravity and elevated CO₂ levels are two important environmental spaceflight stressors that can adversely affect astronaut cognitive performance and jeopardize mission success. This study investigated the effects of 6⁰ head-down tilt bed rest (HDBR) with (N=11 participants, 30 days HDBR) and without (N=8 participants, 60 days HDBR) elevated ambient (3.73 mmHg) CO₂ concentrations on cognitive performance. Participants of both groups performed all 10 tests of NASA's Cognition battery and a brief alertness and mood survey repeatedly before, during, and after the HDBR period. Test scores were adjusted for practice and stimulus set effects. Concentrating on the first 30 days of HDBR, a modest but statistically significant slowing across a range of cognitive domains was found in both groups (Controls: -0.37 SD; 95% CI 0.48, -0.27; adjusted p<0.0001; CO₂: -0.25 SD; 95% CI 0.34, -0.16; adjusted p<0.001), most prominently for sensorimotor speed. These changes were observed early during HDBR and did not further deteriorate or improve with increasing time in HDBR. The study found similar cognitive effects of HDBR irrespective of CO₂ levels, suggesting that elevated CO₂ neither ameliorated nor worsened the HDBR effects. In both groups, cognitive performance after 15 days of recovery was statistically indistinguishable from pre-HDBR performance. However, subjects undergoing 60 days of HDBR rated themselves as feeling more sleepy, tired, physically exhausted, stressed and unhealthy during recovery compared to their 30-day counterparts.

Item URL in elib:https://elib.dlr.de/142643/
Document Type:Article
Title:Effects of Head-Down Tilt Bed Rest Plus Elevated CO₂ on Cognitive Performance
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Basner, M.UNSPECIFIEDUNSPECIFIED
Stahn, A.C.UNSPECIFIEDUNSPECIFIED
Nasrini, J.UNSPECIFIEDUNSPECIFIED
Dinges, D.F.UNSPECIFIEDUNSPECIFIED
Moore, T.M.UNSPECIFIEDUNSPECIFIED
Gur, R.C.UNSPECIFIEDUNSPECIFIED
Mühl, C.christian.muehl (at) dlr.deUNSPECIFIED
Macias, B.R.UNSPECIFIEDUNSPECIFIED
Laurie, S.S.UNSPECIFIEDUNSPECIFIED
Date:19 April 2021
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:130
DOI :10.1152/japplphysiol.00865.2020
Page Range:pp. 1235-1246
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:cognition, spaceflight, performance, microgravity, CO₂
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - User Centre Research under Space Conditions
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Sender, Alina
Deposited On:10 Jun 2021 14:59
Last Modified:10 Jun 2021 14:59

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