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Evaluation of State-of-the-Art Decontamination Techniques and Innovative Prevention Methods on the Astrobiological Model Organism Aspergillus niger

Iannicelli Caiaffa, Manoela (2021) Evaluation of State-of-the-Art Decontamination Techniques and Innovative Prevention Methods on the Astrobiological Model Organism Aspergillus niger. Bachelorarbeit, University of Applied Sciences Bonn-Rhein-Sieg.

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Kurzfassung

Aspergillus niger represents one of the major fungal contaminants inside the International Space Station (ISS). It represents a hazard for human health and can compromise structural installations. It can act as an opportunistic pathogen for humans and can cause a wide variety of issues, such as skin and respiratory tract infections. It affects materials and built structures by excessive growth by releasing secondary metabolites which cause biocorrosion of materials. Fungal spores, the dispersal units and focus of this study have been observed to survive the high doses of radiation and show resistance against most of the commercial sterilization techniques. In this thesis, we tested the state-of-the-art decontamination methods: Autoclavation, UV-C irradiation, and Hydrogen peroxide (H₂​O₂​), using two strains of ​A. niger​. Corresponding results show that the wildtype strain was more capable of survival than a counterpart mutant strain with a melanin deficiency. Secondly, investigations of preventing a manifestation of fungal contamination within a closed built environment, specifically structured copper and copper-containing surfaces were tested for their effect on the viability of spores with similar results. In a nutshell, this thesis demonstrated that ​A. niger spores are capable of surviving harsh conditions, as well as the need for standardization of decontamination techniques. In conclusion, ​A. niger spores should be considered standard sterilization indicator organisms that can be used to indicate sterility in the construction of future equipment to be used in long-term space missions or any other installations that require sterile conditions.

elib-URL des Eintrags:https://elib.dlr.de/141935/
Dokumentart:Hochschulschrift (Bachelorarbeit)
Titel:Evaluation of State-of-the-Art Decontamination Techniques and Innovative Prevention Methods on the Astrobiological Model Organism Aspergillus niger
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Iannicelli Caiaffa, ManoelaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:April 2021
Referierte Publikation:Ja
Open Access:Nein
Seitenanzahl:88
Status:veröffentlicht
Stichwörter:state-of-the-art decontamination methods, Aspergillus niger, Astrobiology
Institution:University of Applied Sciences Bonn-Rhein-Sieg
Abteilung:Department of Natural Sciences
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Luftfahrt
HGF - Programmthema:Luftverkehr und Auswirkungen
DLR - Schwerpunkt:Luftfahrt
DLR - Forschungsgebiet:L AI - Luftverkehr und Auswirkungen
DLR - Teilgebiet (Projekt, Vorhaben):L - Faktor Mensch, R - Projekt ISS LIFE 2.0
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:28 Mai 2021 11:00
Letzte Änderung:28 Mai 2021 11:00

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