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Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment.

Zaccaria, Tommaso and De Jonge, Marien and Netea, Mihai and Domínguez-Andrés, Jorge and Eleveld, Marc and Beblo-Vranesevic, Kristina and Rettberg, Petra (2021) Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment. Jahrestagung 2021 der Vereinigung für Allgemeine und Angewandte Mikrobiologie - VAAM 2021, 18.-19. März 2021, Virtual Conference.

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Abstract

Understanding the extent to which non-fastidious pathogenic bacteria can survive in extraterrestrial conditions will help to guarantee the safety of astronauts. Despite stringent decontamination protocols, terrestrial microorganisms were previously found to travel on the bodies of astronauts, on spaceships and equipment. This might create the possibility that these microorganisms adapt, grow and evolve in the new environment. In this study we assessed the adaptability of clinically relevant bacteria species which are able to grow on carbon-containing compounds identified in carbonaceous meteorites (Klebsiella pneumoniae, Burkholderia cepacia, Serratia marcescens and Pseudomonas aeruginosa). Previous work has shown that bacterial survival and growth under these conditions led to the modification of their cell envelope, in turn altering their pathogenic potential. We continued with this line of research and explored the survival of these bacterial species to a range of Martian conditions: i.e. desiccation, UVC and polychromatic UV irradiation, growth in the presence of perchlorates, growth on Martian soil and Martian atmospheric composition and pressure. Preliminary results showed that growth was enhanced by the addition of Mars Global simulant (mimicking Martian soil). Furthermore, only two of the strains, K. pneumoniae and S. marcescens are resistant to desiccation, up to 16 days. The UVC irradiation experiments have shown that the bacteria with the highest degree of survival are P. aeruginosa and S. marcescens. Likewise, the same two strains have shown higher survival rates compared to K. pneumoniae and B. cepacia following polychromatic UV irradiation, than from UVC irradiation. To understand the consequences of survival and growth under these conditions on virulence and immune recognition, we will analyse the response of immune cells exposed to bacteria adapted to Martian conditions. In addition, gene expression of the adapted bacteria will be further studied. This collaborative study between the DLR and the Radboud UMC, in the Netherlands will improve our insight into the adaptability of pathogenic bacteria to Martian conditions and their effects on virulence and immune recognition to anticipate on the potential risks of infection and inflammation associated with space-travel.

Item URL in elib:https://elib.dlr.de/141633/
Document Type:Conference or Workshop Item (Speech)
Title:Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment.
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Zaccaria, TommasoRadboud University, Microbiology master student, Nijmegen, Netherlands and Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
De Jonge, MarienRadboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands and Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, NetherlandsUNSPECIFIED
Netea, MihaiRadboud University Medical Center, Nijmegen, Netherlands and Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.UNSPECIFIED
Domínguez-Andrés, JorgeRadboud University Medical Center, Nijmegen, Netherlands.UNSPECIFIED
Eleveld, MarcRadboud University Medical Center, Nijmegen, Netherlands.UNSPECIFIED
Beblo-Vranesevic, KristinaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; kristina.beblo (at) dlr.dehttps://orcid.org/0000-0002-4834-7121
Rettberg, PetraRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; petra.rettberg (at) dlr.dehttps://orcid.org/0000-0003-4439-2395
Date:18 March 2021
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:non-fastidious pathogenic bacteria, extraterrestrial conditions, Mars
Event Title:Jahrestagung 2021 der Vereinigung für Allgemeine und Angewandte Mikrobiologie - VAAM 2021
Event Location:Virtual Conference
Event Type:international Conference
Event Dates:18.-19. März 2021
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Project ISS LIFE 2.0
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:31 Mar 2021 08:25
Last Modified:14 Apr 2021 15:57

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