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Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment.

Zaccaria, Tommaso und De Jonge, Marien und Netea, Mihai und Domínguez-Andrés, Jorge und Eleveld, Marc und Beblo-Vranesevic, Kristina und Rettberg, Petra (2021) Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment. Jahrestagung 2021 der Vereinigung für Allgemeine und Angewandte Mikrobiologie - VAAM 2021, 2021-03-18 - 2021-03-19, Virtual Conference.

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Kurzfassung

Understanding the extent to which non-fastidious pathogenic bacteria can survive in extraterrestrial conditions will help to guarantee the safety of astronauts. Despite stringent decontamination protocols, terrestrial microorganisms were previously found to travel on the bodies of astronauts, on spaceships and equipment. This might create the possibility that these microorganisms adapt, grow and evolve in the new environment. In this study we assessed the adaptability of clinically relevant bacteria species which are able to grow on carbon-containing compounds identified in carbonaceous meteorites (Klebsiella pneumoniae, Burkholderia cepacia, Serratia marcescens and Pseudomonas aeruginosa). Previous work has shown that bacterial survival and growth under these conditions led to the modification of their cell envelope, in turn altering their pathogenic potential. We continued with this line of research and explored the survival of these bacterial species to a range of Martian conditions: i.e. desiccation, UVC and polychromatic UV irradiation, growth in the presence of perchlorates, growth on Martian soil and Martian atmospheric composition and pressure. Preliminary results showed that growth was enhanced by the addition of Mars Global simulant (mimicking Martian soil). Furthermore, only two of the strains, K. pneumoniae and S. marcescens are resistant to desiccation, up to 16 days. The UVC irradiation experiments have shown that the bacteria with the highest degree of survival are P. aeruginosa and S. marcescens. Likewise, the same two strains have shown higher survival rates compared to K. pneumoniae and B. cepacia following polychromatic UV irradiation, than from UVC irradiation. To understand the consequences of survival and growth under these conditions on virulence and immune recognition, we will analyse the response of immune cells exposed to bacteria adapted to Martian conditions. In addition, gene expression of the adapted bacteria will be further studied. This collaborative study between the DLR and the Radboud UMC, in the Netherlands will improve our insight into the adaptability of pathogenic bacteria to Martian conditions and their effects on virulence and immune recognition to anticipate on the potential risks of infection and inflammation associated with space-travel.

elib-URL des Eintrags:https://elib.dlr.de/141633/
Dokumentart:Konferenzbeitrag (Vortrag)
Titel:Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment.
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Zaccaria, TommasoRadboud University, Microbiology master student, Nijmegen, Netherlands and Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
De Jonge, MarienRadboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands and Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, NetherlandsNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Netea, MihaiRadboud University Medical Center, Nijmegen, Netherlands and Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Domínguez-Andrés, JorgeRadboud University Medical Center, Nijmegen, Netherlands.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Eleveld, MarcRadboud University Medical Center, Nijmegen, Netherlands.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Beblo-Vranesevic, KristinaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; kristina.beblo (at) dlr.dehttps://orcid.org/0000-0002-4834-7121NICHT SPEZIFIZIERT
Rettberg, PetraRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; petra.rettberg (at) dlr.dehttps://orcid.org/0000-0003-4439-2395NICHT SPEZIFIZIERT
Datum:18 März 2021
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:non-fastidious pathogenic bacteria, extraterrestrial conditions, Mars
Veranstaltungstitel:Jahrestagung 2021 der Vereinigung für Allgemeine und Angewandte Mikrobiologie - VAAM 2021
Veranstaltungsort:Virtual Conference
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:18 März 2021
Veranstaltungsende:19 März 2021
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Projekt ISS LIFE 2.0
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:31 Mär 2021 08:25
Letzte Änderung:24 Apr 2024 20:41

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