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Coffee Effectively Attenuates Impaired Attention in ADORA2A C/C-Allele Carriers During Chronic Sleep Restriction

Baur, D.M. and Lange, D. and Elmenhorst, E.-M. and Elmenhorst, D. and Bauer, A. and Aeschbach, D. and Landolt, H.P. (2020) Coffee Effectively Attenuates Impaired Attention in ADORA2A C/C-Allele Carriers During Chronic Sleep Restriction. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 109, p. 110232. Elsevier. doi: 10.1016/j.pnpbp.2020.110232. ISSN 0278-5846.

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Official URL: https://doi.org/10.1016/j.pnpbp.2020.110232


Many people consume coffee to attenuate increased sleepiness and impaired vigilance and attention due to insufficient sleep. We investigated in genetically caffeine sensitive individuals whether 'real world' coffee consumption during a simulated busy work week counteracts disabling consequences of chronically restricted sleep. We subjected homozygous C-allele carriers of ADORA2A (gene encoding adenosine A2A receptors) to 5 nights of only 5 h time-in-bed. We administered regular coffee (n = 12; 200 mg caffeine at breakfast and 100 mg caffeine after lunch) and decaffeinated coffee (n = 14) in double-blind fashion on all days following sleep restriction. At regular intervals 4 times each day, participants rated their sleepiness and performed the psychomotor vigilance test, the visual search task, and the visuo-spatial and letter n-back tasks. At bedtime, we quantified caffeine and the major caffeine metabolites paraxanthine, theobromine and theophylline in saliva. The 2 groups did not differ in age, body-mass-index, sex-ratio, chronotype and mood states. Subjective sleepiness increased in both groups across consecutive sleep restriction days and did not differ. By contrast, regular coffee counteracted the impact of repeated sleep loss on sustained and selective attention, as well as executive control when compared to decaffeinated coffee. The coffee induced benefits on different aspects of performance lasted for 4-5 days of insufficient sleep. All differences between the groups disappeared after the recovery night and the cessation of coffee administration. The data suggest that 'real world' coffee consumption can efficiently attenuate sleep restriction-induced impairments in vigilance and attention in genetically caffeine sensitive individuals. German Clinical Trial Registry: # DRSK00014379.

Item URL in elib:https://elib.dlr.de/140172/
Document Type:Article
Title:Coffee Effectively Attenuates Impaired Attention in ADORA2A C/C-Allele Carriers During Chronic Sleep Restriction
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Lange, D.denise.lange (at) dlr.deUNSPECIFIED
Elmenhorst, E.-M.Eva-Maria.Elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Aeschbach, D.daniel.aeschbach (at) dlrUNSPECIFIED
Date:26 December 2020
Journal or Publication Title:Progress in Neuro-Psychopharmacology and Biological Psychiatry
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In ISI Web of Science:Yes
DOI :10.1016/j.pnpbp.2020.110232
Page Range:p. 110232
Keywords:Attentional domain networks; Caffeine; Paraxanthine; Pharmacogenetics; Sleepiness; rs5751876
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Sender, Alina
Deposited On:11 Jan 2021 13:49
Last Modified:06 Oct 2021 13:50

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