elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Coffee Effectively Attenuates Impaired Attention in ADORA2A C/C-Allele Carriers During Chronic Sleep Restriction

Baur, D.M. and Lange, D. and Elmenhorst, E.-M. and Elmenhorst, D. and Bauer, A. and Aeschbach, D. and Landolt, H.P. (2020) Coffee Effectively Attenuates Impaired Attention in ADORA2A C/C-Allele Carriers During Chronic Sleep Restriction. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 109, p. 110232. Elsevier. doi: 10.1016/j.pnpbp.2020.110232. ISSN 0278-5846.

[img] PDF - Published version
3MB

Official URL: https://doi.org/10.1016/j.pnpbp.2020.110232

Abstract

Many people consume coffee to attenuate increased sleepiness and impaired vigilance and attention due to insufficient sleep. We investigated in genetically caffeine sensitive individuals whether 'real world' coffee consumption during a simulated busy work week counteracts disabling consequences of chronically restricted sleep. We subjected homozygous C-allele carriers of ADORA2A (gene encoding adenosine A2A receptors) to 5 nights of only 5 h time-in-bed. We administered regular coffee (n = 12; 200 mg caffeine at breakfast and 100 mg caffeine after lunch) and decaffeinated coffee (n = 14) in double-blind fashion on all days following sleep restriction. At regular intervals 4 times each day, participants rated their sleepiness and performed the psychomotor vigilance test, the visual search task, and the visuo-spatial and letter n-back tasks. At bedtime, we quantified caffeine and the major caffeine metabolites paraxanthine, theobromine and theophylline in saliva. The 2 groups did not differ in age, body-mass-index, sex-ratio, chronotype and mood states. Subjective sleepiness increased in both groups across consecutive sleep restriction days and did not differ. By contrast, regular coffee counteracted the impact of repeated sleep loss on sustained and selective attention, as well as executive control when compared to decaffeinated coffee. The coffee induced benefits on different aspects of performance lasted for 4-5 days of insufficient sleep. All differences between the groups disappeared after the recovery night and the cessation of coffee administration. The data suggest that 'real world' coffee consumption can efficiently attenuate sleep restriction-induced impairments in vigilance and attention in genetically caffeine sensitive individuals. German Clinical Trial Registry: # DRSK00014379.

Item URL in elib:https://elib.dlr.de/140172/
Document Type:Article
Title:Coffee Effectively Attenuates Impaired Attention in ADORA2A C/C-Allele Carriers During Chronic Sleep Restriction
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Baur, D.M.UNSPECIFIEDUNSPECIFIED
Lange, D.denise.lange (at) dlr.deUNSPECIFIED
Elmenhorst, E.-M.Eva-Maria.Elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Elmenhorst, D.UNSPECIFIEDUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlrUNSPECIFIED
Landolt, H.P.UNSPECIFIEDUNSPECIFIED
Date:26 December 2020
Journal or Publication Title:Progress in Neuro-Psychopharmacology and Biological Psychiatry
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:109
DOI :10.1016/j.pnpbp.2020.110232
Page Range:p. 110232
Publisher:Elsevier
ISSN:0278-5846
Status:Published
Keywords:Attentional domain networks; Caffeine; Paraxanthine; Pharmacogenetics; Sleepiness; rs5751876
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Sender, Alina
Deposited On:11 Jan 2021 13:49
Last Modified:06 Oct 2021 13:50

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.