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Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest

Ward, K. and Mulder, E. and Frings-Meuthen, P. and O’Gorman, D.J. and Cooper, D. (2020) Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest. Frontiers in Physiology, 11, p. 573581. Frontiers Media S.A. doi: 10.3389/fphys.2020.573581. ISSN 1664-042X.

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Official URL: https://www.frontiersin.org/articles/10.3389/fphys.2020.573581/full


Background: Fetuin-A is a hepatokine linked to the development of insulin resistance. The purpose of this study was to determine if 60 days head-down-tilt (HDT) bed rest increased circulating fetuin-A and if it was linked to whole body insulin sensitivity (IS). Additionally, we examined whether reactive jump training (RJT) could alleviate the metabolic changes associated with bed rest. Methods: 23 young men (29 ± 6 years, 181 ± 6 cm, 77 ± 7 kg) were randomized to a control (CTRL, n = 11) or RJT group (JUMP, n = 12) and exposed to 60 days of bed rest. Before and after bed rest, body composition and V . O 2peak V.O2⁢p⁢e⁢a⁢k were measured and an oral glucose tolerance test was performed to estimate IS. Circulating lipids and fetuin-A were measured in fasting serum. Results: Body weight, lean mass, and V . O 2peak V.O2⁢p⁢e⁢a⁢k decreased in both groups following bed rest, with greater reductions in CTRL (p < 0.05). There was a main effect of time, but not the RJT intervention, for the increase in fetuin-A, triglycerides (TG), area under the curve for glucose (AUCG) and insulin (AUCI), and the decrease in Matsuda and tissue-specific IS (p < 0.05). Fetuin-A increased in participants who became less insulin sensitive (p = 0.019). In this subgroup, liver IS and adipose IS decreased (p < 0.05), while muscle IS was unchanged. In a subgroup, where IS did not decrease, fetuin-A did not change. Liver IS increased (p = 0.012), while muscle and adipose tissue IS remained unchanged. Conclusions: In this study, we report an increase in circulating fetuin-A following 60 days of bed rest, concomitant with reduced IS, which could not be mitigated by RJT. The amount of fetuin-A released from the liver may be an important determinant of changes in whole body IS. In this regard, it may also be a useful biomarker of individual variation due to inactivity or lifestyle interventions.

Item URL in elib:https://elib.dlr.de/140149/
Document Type:Article
Title:Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Ward, K.Faculty of Science and Health, Athlone Institute of Technology, Athlone, Ireland,UNSPECIFIEDUNSPECIFIED
Mulder, E.german aerospace center (dlr), institute of aerospace medicine, biomedical science support center, cologne, germanyUNSPECIFIEDUNSPECIFIED
O’Gorman, D.J.3U Diabetes Partnership, School of Health and Human Performance, Dublin City University, Dublin, IrelandUNSPECIFIEDUNSPECIFIED
Cooper, D.Faculty of Science and Health, Athlone Institute of Technology, Athlone, IrelandUNSPECIFIEDUNSPECIFIED
Date:19 October 2020
Journal or Publication Title:Frontiers in Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:p. 573581
Publisher:Frontiers Media S.A
Keywords:bed rest, fetuin-A, hepatokine, insulin sensitivity, liver, metabolism
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Arndt, Carina
Deposited On:11 Jan 2021 13:20
Last Modified:11 Jan 2021 13:20

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