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Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest

Ward, K. und Mulder, E. und Frings-Meuthen, P. und O’Gorman, D.J. und Cooper, D. (2020) Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest. Frontiers in Physiology, 11, Seite 573581. Frontiers Media S.A. doi: 10.3389/fphys.2020.573581. ISSN 1664-042X.

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Offizielle URL: https://www.frontiersin.org/articles/10.3389/fphys.2020.573581/full

Kurzfassung

Background: Fetuin-A is a hepatokine linked to the development of insulin resistance. The purpose of this study was to determine if 60 days head-down-tilt (HDT) bed rest increased circulating fetuin-A and if it was linked to whole body insulin sensitivity (IS). Additionally, we examined whether reactive jump training (RJT) could alleviate the metabolic changes associated with bed rest. Methods: 23 young men (29 ± 6 years, 181 ± 6 cm, 77 ± 7 kg) were randomized to a control (CTRL, n = 11) or RJT group (JUMP, n = 12) and exposed to 60 days of bed rest. Before and after bed rest, body composition and V . O 2peak V.O2⁢p⁢e⁢a⁢k were measured and an oral glucose tolerance test was performed to estimate IS. Circulating lipids and fetuin-A were measured in fasting serum. Results: Body weight, lean mass, and V . O 2peak V.O2⁢p⁢e⁢a⁢k decreased in both groups following bed rest, with greater reductions in CTRL (p < 0.05). There was a main effect of time, but not the RJT intervention, for the increase in fetuin-A, triglycerides (TG), area under the curve for glucose (AUCG) and insulin (AUCI), and the decrease in Matsuda and tissue-specific IS (p < 0.05). Fetuin-A increased in participants who became less insulin sensitive (p = 0.019). In this subgroup, liver IS and adipose IS decreased (p < 0.05), while muscle IS was unchanged. In a subgroup, where IS did not decrease, fetuin-A did not change. Liver IS increased (p = 0.012), while muscle and adipose tissue IS remained unchanged. Conclusions: In this study, we report an increase in circulating fetuin-A following 60 days of bed rest, concomitant with reduced IS, which could not be mitigated by RJT. The amount of fetuin-A released from the liver may be an important determinant of changes in whole body IS. In this regard, it may also be a useful biomarker of individual variation due to inactivity or lifestyle interventions.

elib-URL des Eintrags:https://elib.dlr.de/140149/
Dokumentart:Zeitschriftenbeitrag
Titel:Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Ward, K.Faculty of Science and Health, Athlone Institute of Technology, Athlone, Ireland,NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Mulder, E.german aerospace center (dlr), institute of aerospace medicine, biomedical science support center, cologne, germanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Frings-Meuthen, P.Petra.Frings-Meuthen (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
O’Gorman, D.J.3U Diabetes Partnership, School of Health and Human Performance, Dublin City University, Dublin, IrelandNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Cooper, D.Faculty of Science and Health, Athlone Institute of Technology, Athlone, IrelandNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:19 Oktober 2020
Erschienen in:Frontiers in Physiology
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:11
DOI:10.3389/fphys.2020.573581
Seitenbereich:Seite 573581
Verlag:Frontiers Media S.A
ISSN:1664-042X
Status:veröffentlicht
Stichwörter:bed rest, fetuin-A, hepatokine, insulin sensitivity, liver, metabolism
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Systemphysiologie (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Muskel- und Knochenstoffwechsel
Institut für Luft- und Raumfahrtmedizin > Leitungsbereich ME
Hinterlegt von: Arndt, Carina
Hinterlegt am:11 Jan 2021 13:20
Letzte Änderung:11 Jan 2021 13:20

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