elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes

Saatmann, Nina and Zaharia, Oana-Patricia and Loenneke, Jeremy P. and Roden, Michael and Pesta, Dominik H. (2020) Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes. Trends in Endocrinology and Metabolism, Online ahead of print. Elsevier. doi: 10.1016/j.tem.2020.11.010. ISSN 1043-2760.

Full text not available from this repository.

Official URL: https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(20)30234-4

Abstract

Blood flow restriction resistance training (BFRT), that is exercising under partial vascular occlusion via inflation cuffs – can induce gains in skeletal muscle mass and strength similar to those seen with classical resistance training, albeit with marked lower training load. Mechanistically, BFRT leads to accumulation of metabolites in myocytes and triggers the recruitment of higher-threshold motoneurons, induces cell swelling, and promotes protein biosynthesis, resulting in increased muscle mass and strength. Furthermore, low myocellular oxygen tension can induce angiogenesis, increase reactive oxygen species (ROS) production, mitochondrial biogenesis, and glucose transporter (GLUT) 4 expression. In addition to impaired glucose metabolism and physical fitness, individuals with type 2 diabetes are at increased risk of sarcopenia. For these individuals, low-load BFRT may be an effective exercise modality. Blood flow restriction resistance training (BFRT) employs partial vascular occlusion of exercising muscles via inflation cuffs. Compared with high-load resistance training, mechanical load is markedly reduced with BFRT, but induces similar gains in muscle mass and strength. BFRT is thus an effective training strategy for people with physical limitations. Recent research indicates that BFRT has beneficial effects on glucose and mitochondrial metabolism. BFRT may therefore qualify as a valuable exercise alternative for individuals with type 2 diabetes (T2D), a disorder characterized by impaired glucose metabolism, musculoskeletal decline, and exacerbated progression of sarcopenia. This review covers the effects of BFRT in healthy populations and in persons with impaired physical fitness, the mechanisms of action of this novel training modality, and possible applications for individuals with T2D.

Item URL in elib:https://elib.dlr.de/140147/
Document Type:Article
Title:Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Saatmann, NinaInstitute for Clinical Diabetology, Leibniz Center for Diabetes Research at HeinrichHeine University Düsseldorf, German Diabetes Center, Düsseldorf, GermanyUNSPECIFIED
Zaharia, Oana-PatriciaInstitute for Clinical Diabetology, Leibniz Center for Diabetes Research at HeinrichHeine University Düsseldorf, German Diabetes Center, Düsseldorf, GermanyUNSPECIFIED
Loenneke, Jeremy P.Department of Health, Exercise Science, and Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, Oxford, MS, USAUNSPECIFIED
Roden, MichaelInstitute for Clinical Diabetology, Leibniz Center for Diabetes Research at HeinrichHeine University Düsseldorf, German Diabetes Center, Düsseldorf, GermanyUNSPECIFIED
Pesta, Dominik H.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0002-5089-3586
Date:24 December 2020
Journal or Publication Title:Trends in Endocrinology and Metabolism
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1016/j.tem.2020.11.010
Page Range:Online ahead of print
Publisher:Elsevier
ISSN:1043-2760
Status:Published
Keywords:blood flow restriction training, resistance training, muscle mass, muscle strength, type 2 diabetes mellitus
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Arndt, Carina
Deposited On:12 Jan 2021 10:34
Last Modified:12 Jan 2021 10:35

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.