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Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes

Saatmann, Nina und Zaharia, Oana-Patricia und Loenneke, Jeremy P. und Roden, Michael und Pesta, Dominik H. (2020) Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes. Trends in Endocrinology and Metabolism, 32 (2), Seiten 106-117. Elsevier. doi: 10.1016/j.tem.2020.11.010. ISSN 1043-2760.

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Offizielle URL: https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(20)30234-4

Kurzfassung

Blood flow restriction resistance training (BFRT), that is exercising under partial vascular occlusion via inflation cuffs – can induce gains in skeletal muscle mass and strength similar to those seen with classical resistance training, albeit with marked lower training load. Mechanistically, BFRT leads to accumulation of metabolites in myocytes and triggers the recruitment of higher-threshold motoneurons, induces cell swelling, and promotes protein biosynthesis, resulting in increased muscle mass and strength. Furthermore, low myocellular oxygen tension can induce angiogenesis, increase reactive oxygen species (ROS) production, mitochondrial biogenesis, and glucose transporter (GLUT) 4 expression. In addition to impaired glucose metabolism and physical fitness, individuals with type 2 diabetes are at increased risk of sarcopenia. For these individuals, low-load BFRT may be an effective exercise modality. Blood flow restriction resistance training (BFRT) employs partial vascular occlusion of exercising muscles via inflation cuffs. Compared with high-load resistance training, mechanical load is markedly reduced with BFRT, but induces similar gains in muscle mass and strength. BFRT is thus an effective training strategy for people with physical limitations. Recent research indicates that BFRT has beneficial effects on glucose and mitochondrial metabolism. BFRT may therefore qualify as a valuable exercise alternative for individuals with type 2 diabetes (T2D), a disorder characterized by impaired glucose metabolism, musculoskeletal decline, and exacerbated progression of sarcopenia. This review covers the effects of BFRT in healthy populations and in persons with impaired physical fitness, the mechanisms of action of this novel training modality, and possible applications for individuals with T2D.

elib-URL des Eintrags:https://elib.dlr.de/140147/
Dokumentart:Zeitschriftenbeitrag
Titel:Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Saatmann, NinaInstitute for Clinical Diabetology, Leibniz Center for Diabetes Research at HeinrichHeine University Düsseldorf, German Diabetes Center, Düsseldorf, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Zaharia, Oana-PatriciaInstitute for Clinical Diabetology, Leibniz Center for Diabetes Research at HeinrichHeine University Düsseldorf, German Diabetes Center, Düsseldorf, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Loenneke, Jeremy P.Department of Health, Exercise Science, and Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, Oxford, MS, USANICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Roden, MichaelInstitute for Clinical Diabetology, Leibniz Center for Diabetes Research at HeinrichHeine University Düsseldorf, German Diabetes Center, Düsseldorf, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Pesta, Dominik H.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0002-5089-3586NICHT SPEZIFIZIERT
Datum:24 Dezember 2020
Erschienen in:Trends in Endocrinology and Metabolism
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:32
DOI:10.1016/j.tem.2020.11.010
Seitenbereich:Seiten 106-117
Verlag:Elsevier
ISSN:1043-2760
Status:veröffentlicht
Stichwörter:blood flow restriction training, resistance training, muscle mass, muscle strength, type 2 diabetes mellitus
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Systemphysiologie (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Muskel- und Knochenstoffwechsel
Hinterlegt von: Arndt, Carina
Hinterlegt am:12 Jan 2021 10:34
Letzte Änderung:30 Jan 2024 11:23

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