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Gravity and Mastoid Effusion

Lecheler, L. and Paulke, F. and Sonnow, L. and Limper, U. and Schwarz, D. and Jansen, S. and Klussmann, J.P. and Tank, J. and Jordan, J. (2020) Gravity and Mastoid Effusion. The American Journal of Medicine, 134 (3), e181-e183. Elsevier. doi: 10.1016/j.amjmed.2020.09.020. ISSN 0002-9343.

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Official URL: https://doi.org/10.1016/j.amjmed.2020.09.020

Abstract

Background: Asymptomatic mastoid effusions have recently been observed in astronauts returning from long-term spaceflight. In hospitalized patients, mastoid effusion increases the risks for bacterial otitis and mastoiditis. We reasoned that cephalad fluid shifts during strict -6° head down tilt bed rest could reproduce space-flight associated mastoid effusion and that artificial gravity may reverse the response. Methods: The recent Artificial Gravity Bed Rest Study-European Space Agency study (AGBRESA) tested influences of artificial gravity during 60 days head down bed rest on a short-arm human centrifuge in healthy participants. The two intervention groups received daily artificial gravity with 30 minutes continuous artificial gravity or intermittent artificial gravity. A third group served as a control group and received no artificial gravity. We assessed cranial magnetic resonance images for mastoid effusions 1 day before bed rest, at days 14 and 52 of bed rest, and 3 days after bed rest. Results: None of the participants exhibited mastoid effusions before bed rest. Six participants showed mastoid effusions at bed rest day 14 (4 continuous, 2 intermittent, 0 control). Fifteen participants showed mastoid effusions at bed rest day 52 and 3 days after bed rest (7 continuous, 3 intermittent, 5 control). Conclusions: Mastoid effusions commonly occur during strict head down tilt bed rest. The model can be applied to study the mechanisms and potential countermeasures for space flight-associated mastoid effusions. Formation of mastoid effusions during head down tilt bed rest is not prevented by daily 30 minutes short-arm intermittent or continuous centrifugation.

Item URL in elib:https://elib.dlr.de/140036/
Document Type:Article
Title:Gravity and Mastoid Effusion
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Lecheler, L.Study Team, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Paulke, F.Study Team, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Sonnow, L.Department of Diagnostic and Interventional Radiology, Hannover Medical School, GermanyUNSPECIFIED
Limper, U.Ulrich.Limper (at) dlr.dehttps://orcid.org/0000-0001-9927-4180
Schwarz, D.University of Cologne, Medical Faculty, Department of Otorhinolaryngology, Head and Neck Surgery, GermanyUNSPECIFIED
Jansen, S.University of Cologne, Medical Faculty, Department of Otorhinolaryngology, Head and Neck Surgery, GermanyUNSPECIFIED
Klussmann, J.P.University of Cologne, Medical Faculty, Department of Otorhinolaryngology, Head and Neck Surgery, GermanyUNSPECIFIED
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Date:25 October 2020
Journal or Publication Title:The American Journal of Medicine
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:134
DOI :10.1016/j.amjmed.2020.09.020
Page Range:e181-e183
Publisher:Elsevier
ISSN:0002-9343
Status:Published
Keywords:Gravity; Artificial Gravity Bed Rest Study-European Space Agency study (AGBRESA); Mastoid Effusion
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:07 Jan 2021 10:18
Last Modified:20 Apr 2021 13:46

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