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Simulated Hypergravity Activates Hemostasis in Healthy Volunteers

Limper, U. and Ahnert, T. and Maegele, M. and Froehlich, M. and Grau, M. and Gauger, P. and Bauerfeind, U. and Görlinger, K. and Pötzsch, B. and Jordan, J. (2020) Simulated Hypergravity Activates Hemostasis in Healthy Volunteers. Journal of the American Heart Association, 9 (24), e016479. Wiley. doi: 10.1161/JAHA.120.016479. ISSN 2047-9980.

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Official URL: http://dx.doi.org/10.1161/JAHA.120.016479

Abstract

Background Hypergravity may promote human hemostasis thereby increasing thrombotic risk. Future touristic suborbital spaceflight will expose older individuals with chronic medical conditions, who are at much higher thromboembolic risk compared with professional astronauts, to hypergravity. Therefore, we tested the impact of hypergravity on hemostasis in healthy volunteers undergoing centrifugation. Methods and Results We studied 20 healthy seated men before and after 15 minutes under 3 Gz hypergravity on a long‐arm centrifuge. We obtained blood samples for hemostasis testing before, immediately after, and 30 minutes after centrifugation. Tests included viscoelastic thromboelastometry, platelet impedance aggregometry, endothelial activation markers, blood rheology testing, microparticle analyses, and clotting factor analysis. Exposure to hypergravity reduced plasma volume by 12.5% (P=0.002) and increased the red blood cell aggregation index (P<0.05). With hypergravity, thrombelastographic clotting time of native blood shortened from 719±117 seconds to 628±89 seconds (P=0.038) and platetet reactivity increased (P=0.045). Hypergravity shortened partial thromboplastin time from 28 (26–29) seconds to 25 (24–28) seconds (P<0.001) and increased the activity of coagulation factors (eg, factor VIII 117 [93–134] versus 151 [133–175] %, P<0.001). Tissue factor concentration was 188±95 pg/mL before and 298±136 pg/mL after hypergravity exposure (P=0.023). Antithrombin (P=0.005), thrombin‐antithrombin complex (P<0.001), plasmin‐alpha2‐antiplasmin complex (0.002), tissue‐plasminogen activatior (P<0.001), and plasminogen activator inhibitor‐1 (P=0.002) increased with centrifugation. Statistical adjustment for plasma volume attenuated changes in coagulation. Conclusions Hypergravity triggers low‐level hemostasis activation through endothelial cell activation, increased viscoelasticity, and augmented platelet reactivity, albeit partly counteracted through endogenous coagulation inhibitors release. Hemoconcentration may contribute to the response.

Item URL in elib:https://elib.dlr.de/140031/
Document Type:Article
Title:Simulated Hypergravity Activates Hemostasis in Healthy Volunteers
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Limper, U.Ulrich.Limper (at) dlr.dehttps://orcid.org/0000-0001-9927-4180
Ahnert, T.UNSPECIFIEDUNSPECIFIED
Maegele, M.UNSPECIFIEDUNSPECIFIED
Froehlich, M.UNSPECIFIEDUNSPECIFIED
Grau, M.UNSPECIFIEDUNSPECIFIED
Gauger, P.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Bauerfeind, U.UNSPECIFIEDUNSPECIFIED
Görlinger, K.UNSPECIFIEDUNSPECIFIED
Pötzsch, B.UNSPECIFIEDUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Date:7 December 2020
Journal or Publication Title:Journal of the American Heart Association
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:9
DOI :10.1161/JAHA.120.016479
Page Range:e016479
Publisher:Wiley
ISSN:2047-9980
Status:Published
Keywords:astronaut; blood coagulation; commercial spaceflight; human spaceflight; thrombotic risk
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:11 Jan 2021 14:37
Last Modified:11 Jan 2021 14:37

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