Limper, U. und Ahnert, T. und Maegele, M. und Froehlich, M. und Grau, M. und Gauger, P. und Bauerfeind, U. und Görlinger, K. und Pötzsch, B. und Jordan, J. (2020) Simulated Hypergravity Activates Hemostasis in Healthy Volunteers. Journal of the American Heart Association, 9 (24), e016479. Wiley. doi: 10.1161/JAHA.120.016479. ISSN 2047-9980.
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Offizielle URL: http://dx.doi.org/10.1161/JAHA.120.016479
Kurzfassung
Background Hypergravity may promote human hemostasis thereby increasing thrombotic risk. Future touristic suborbital spaceflight will expose older individuals with chronic medical conditions, who are at much higher thromboembolic risk compared with professional astronauts, to hypergravity. Therefore, we tested the impact of hypergravity on hemostasis in healthy volunteers undergoing centrifugation. Methods and Results We studied 20 healthy seated men before and after 15 minutes under 3 Gz hypergravity on a long‐arm centrifuge. We obtained blood samples for hemostasis testing before, immediately after, and 30 minutes after centrifugation. Tests included viscoelastic thromboelastometry, platelet impedance aggregometry, endothelial activation markers, blood rheology testing, microparticle analyses, and clotting factor analysis. Exposure to hypergravity reduced plasma volume by 12.5% (P=0.002) and increased the red blood cell aggregation index (P<0.05). With hypergravity, thrombelastographic clotting time of native blood shortened from 719±117 seconds to 628±89 seconds (P=0.038) and platetet reactivity increased (P=0.045). Hypergravity shortened partial thromboplastin time from 28 (26–29) seconds to 25 (24–28) seconds (P<0.001) and increased the activity of coagulation factors (eg, factor VIII 117 [93–134] versus 151 [133–175] %, P<0.001). Tissue factor concentration was 188±95 pg/mL before and 298±136 pg/mL after hypergravity exposure (P=0.023). Antithrombin (P=0.005), thrombin‐antithrombin complex (P<0.001), plasmin‐alpha2‐antiplasmin complex (0.002), tissue‐plasminogen activatior (P<0.001), and plasminogen activator inhibitor‐1 (P=0.002) increased with centrifugation. Statistical adjustment for plasma volume attenuated changes in coagulation. Conclusions Hypergravity triggers low‐level hemostasis activation through endothelial cell activation, increased viscoelasticity, and augmented platelet reactivity, albeit partly counteracted through endogenous coagulation inhibitors release. Hemoconcentration may contribute to the response.
elib-URL des Eintrags: | https://elib.dlr.de/140031/ | ||||||||||||||||||||||||||||||||||||||||||||
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Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||||||||||||||||||||||||||
Titel: | Simulated Hypergravity Activates Hemostasis in Healthy Volunteers | ||||||||||||||||||||||||||||||||||||||||||||
Autoren: |
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Datum: | 7 Dezember 2020 | ||||||||||||||||||||||||||||||||||||||||||||
Erschienen in: | Journal of the American Heart Association | ||||||||||||||||||||||||||||||||||||||||||||
Referierte Publikation: | Ja | ||||||||||||||||||||||||||||||||||||||||||||
Open Access: | Ja | ||||||||||||||||||||||||||||||||||||||||||||
Gold Open Access: | Ja | ||||||||||||||||||||||||||||||||||||||||||||
In SCOPUS: | Ja | ||||||||||||||||||||||||||||||||||||||||||||
In ISI Web of Science: | Ja | ||||||||||||||||||||||||||||||||||||||||||||
Band: | 9 | ||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1161/JAHA.120.016479 | ||||||||||||||||||||||||||||||||||||||||||||
Seitenbereich: | e016479 | ||||||||||||||||||||||||||||||||||||||||||||
Verlag: | Wiley | ||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 2047-9980 | ||||||||||||||||||||||||||||||||||||||||||||
Status: | veröffentlicht | ||||||||||||||||||||||||||||||||||||||||||||
Stichwörter: | astronaut; blood coagulation; commercial spaceflight; human spaceflight; thrombotic risk | ||||||||||||||||||||||||||||||||||||||||||||
HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||||||||||||||||||||||||||||||||||||||
HGF - Programm: | Raumfahrt | ||||||||||||||||||||||||||||||||||||||||||||
HGF - Programmthema: | Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||||||||||||||||||
DLR - Schwerpunkt: | Raumfahrt | ||||||||||||||||||||||||||||||||||||||||||||
DLR - Forschungsgebiet: | R FR - Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||||||||||||||||||
DLR - Teilgebiet (Projekt, Vorhaben): | R - Vorhaben Systemphysiologie (alt) | ||||||||||||||||||||||||||||||||||||||||||||
Standort: | Köln-Porz | ||||||||||||||||||||||||||||||||||||||||||||
Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin Institut für Luft- und Raumfahrtmedizin > Kardiovaskuläre Luft- und Raumfahrtmedizin Institut für Luft- und Raumfahrtmedizin > Leitungsbereich ME | ||||||||||||||||||||||||||||||||||||||||||||
Hinterlegt von: | Schrage, Larissa | ||||||||||||||||||||||||||||||||||||||||||||
Hinterlegt am: | 11 Jan 2021 14:37 | ||||||||||||||||||||||||||||||||||||||||||||
Letzte Änderung: | 24 Okt 2023 14:21 |
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