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Cardiac adaptations to 60 day head‐down‐tilt bed rest deconditioning. Findings from the AGBRESA study

Hoffmann, F. and Rabineau, J. and Mehrkens, D. and Gerlach, D.A. and Moestl, S. and Johannes, B. and Caiani, E.G. and Migeotte, P-F. and Jordan, J. and Tank, J. (2020) Cardiac adaptations to 60 day head‐down‐tilt bed rest deconditioning. Findings from the AGBRESA study. ESC heart failure, 8 (1), pp. 729-744. Wiley. doi: 10.1002/ehf2.13103. ISSN 2055-5822.

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Official URL: http://dx.doi.org/10.1002/ehf2.13103

Abstract

Aims: Reduced physical activity increases the risk of heart failure; however, non-invasive methodologies detecting subclinical changes in myocardial function are not available. We hypothesized that myocardial, left ventricular, systolic strain measurements could capture subtle abnormalities in myocardial function secondary to physical inactivity. Methods and results: In the AGBRESA study, which assessed artificial gravity through centrifugation as potential countermeasure for space travel, 24 healthy persons (eight women) were submitted to 60 day strict -6° head-down-tilt bed rest. Participants were assigned to three groups of eight subjects: a control group, continuous artificial gravity training on a short-arm centrifuge (30 min/day), or intermittent centrifugation (6 × 5 min/day). We assessed cardiac morphology, function, strain, and haemodynamics by cardiac magnetic resonance imaging (MRI) and echocardiography. We observed no differences between groups and, therefore, conducted a pooled analysis. Consistent with deconditioning, resting heart rate (∆8.3 ± 6.3 b.p.m., P < 0.0001), orthostatic heart rate responses (∆22.8 ± 19.7 b.p.m., P < 0.0001), and diastolic blood pressure (∆8.8 ± 6.6 mmHg, P < 0.0001) increased, whereas cardiac output (∆-0.56 ± 0.94 L/min, P = 0.0096) decreased during bed rest. Left ventricular mass index obtained by MRI did not change. Echocardiographic left ventricular, systolic, global longitudinal strain (∆1.8 ± 1.83%, P < 0.0001) decreased, whereas left ventricular, systolic, global MRI circumferential strain increased not significantly (∆-0.68 ± 1.85%, P = 0.0843). MRI values rapidly returned to baseline during recovery. Conclusion: Prolonged head-down-tilt bed rest provokes changes in cardiac function, particularly strain measurements, that appear functional rather than mediated through cardiac remodelling. Thus, strain measurements are of limited utility in assessing influences of physical deconditioning or exercise interventions on cardiac function.

Item URL in elib:https://elib.dlr.de/140028/
Document Type:Article
Title:Cardiac adaptations to 60 day head‐down‐tilt bed rest deconditioning. Findings from the AGBRESA study
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIED
Rabineau, J.LPHYS, Université Libre de Bruxelles, Brussels, BelgiumUNSPECIFIED
Mehrkens, D.Department of Internal Medicine III, University of Cologne, Cologne, GermanyUNSPECIFIED
Gerlach, D.A.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0001-7044-6065
Moestl, S.German Aerospace Center, Cologne, GermanyUNSPECIFIED
Johannes, B.Division Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, bernd.johannes (at) dlr.deUNSPECIFIED
Caiani, E.G.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIED
Migeotte, P-F.pierre-francois.migeotte (at) elec.rma.ac.beUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Date:15 November 2020
Journal or Publication Title:ESC heart failure
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:8
DOI :10.1002/ehf2.13103
Page Range:pp. 729-744
Publisher:Wiley
ISSN:2055-5822
Status:Published
Keywords:Bed rest; Cardiac atrophy; Heart failure; Immobilization; Myocardial strain
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:13 Jan 2021 11:30
Last Modified:20 Apr 2021 13:26

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