elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Exposure to acute normobaric hypoxia results in adaptions of both the macro- and microcirculatory system

Mirna, M. and Bimpong-Buta, N.-Y. and Hoffmann, F. and Abusamrah, T. and Knost, T. and Sander, O. and Hew, Y. M. and Lichtenauer, M. and Muessig, J. M. and Bruno, R. R. and Kelm, M. and Zange, J. and Wilhelm, J. and Limper, U. and Jordan, J. and Tank, J. and Jung, C. (2020) Exposure to acute normobaric hypoxia results in adaptions of both the macro- and microcirculatory system. Scientific Reports, 10 (1), p. 20938. Nature Publishing Group. doi: 10.1038/s41598-020-77724-5. ISSN 2045-2322.

[img] PDF - Published version
1MB

Official URL: http://dx.doi.org/10.1038/s41598-020-77724-5

Abstract

Although acute hypoxia is of utmost pathophysiologic relevance in health and disease, studies on its effects on both the macro- and microcirculation are scarce. Herein, we provide a comprehensive analysis of the effects of acute normobaric hypoxia on human macro- and microcirculation. 20 healthy participants were enrolled in this study. Hypoxia was induced in a normobaric hypoxia chamber by decreasing the partial pressure of oxygen in inhaled air stepwisely (pO₂; 21.25 kPa (0 k), 16.42 kPa (2 k), 12.63 kPa (4 k) and 9.64 kPa (6 k)). Macrocirculatory effects were assessed by cardiac output measurements, microcirculatory changes were investigated by sidestream dark-field imaging in the sublingual capillary bed and videocapillaroscopy at the nailfold. Exposure to hypoxia resulted in a decrease of systemic vascular resistance (p < 0.0001) and diastolic blood pressure (p = 0.014). Concomitantly, we observed an increase in heart rate (p < 0.0001) and an increase of cardiac output (p < 0.0001). In the sublingual microcirculation, exposure to hypoxia resulted in an increase of total vessel density, proportion of perfused vessels and perfused vessel density. Furthermore, we observed an increase in peripheral capillary density. Exposure to acute hypoxia results in vasodilatation of resistance arteries, as well as recruitment of microvessels of the central and peripheral microcirculation. The observed macro- and microcirculatory effects are most likely a result from compensatory mechanisms to ensure adequate tissue oxygenation.

Item URL in elib:https://elib.dlr.de/140026/
Document Type:Article
Title:Exposure to acute normobaric hypoxia results in adaptions of both the macro- and microcirculatory system
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Mirna, M.Division of Cardiology, Department of Internal Medicine II, Paracelsus Medical University of Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, AustriaUNSPECIFIED
Bimpong-Buta, N.-Y.Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, GermanyUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Abusamrah, T.Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, GermanyUNSPECIFIED
Knost, T.Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, GermanyUNSPECIFIED
Sander, O.Department of Rheumatology, Hiller Research Institute for Rheumatology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, GermanyUNSPECIFIED
Hew, Y. M.Department of Aeronautics and Astronautics, Stanford University, Stanford, CA, 94305, USAUNSPECIFIED
Lichtenauer, M.Division of Cardiology, Department of Internal Medicine II, Paracelsus Medical University of Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, AustriaUNSPECIFIED
Muessig, J. M.Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, GermanyUNSPECIFIED
Bruno, R. R.Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, GermanyUNSPECIFIED
Kelm, M.Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, GermanyUNSPECIFIED
Zange, J.Jochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Wilhelm, J.Institut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt, KölnUNSPECIFIED
Limper, U.Ulrich.Limper (at) dlr.dehttps://orcid.org/0000-0001-9927-4180
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Jung, C.Christian.Jung (at) dlr.dehttps://orcid.org/0000-0002-5893-4979
Date:1 December 2020
Journal or Publication Title:Scientific Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:10
DOI :10.1038/s41598-020-77724-5
Page Range:p. 20938
Publisher:Nature Publishing Group
ISSN:2045-2322
Status:Published
Keywords:Cardiology; Hypoxia; Medical research; Pathogenesis
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Schrage, Larissa
Deposited On:07 Jan 2021 10:09
Last Modified:15 Jul 2021 16:26

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.