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Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study

Sujana, Chaterina and Seissler, Jochen and Jordan, Jens and Rathmann, Wolfgang and Koenig, Wolfgang and Roden, Michael and Mansmann, Ulrich and Herder, Christian and Peters, Annette and Thorand, Barbara and Then, Cornelia (2020) Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study. Cardiovascular Diabetology, 19 (1), p. 178. BioMed Central. doi: 10.1186/s12933-020-01117-1. ISSN 1475-2840.

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Official URL: https://doi.org/10.1186/s12933-020-01117-1

Abstract

Background: High N-terminal pro-brain-type natriuretic peptide levels have been associated with a lower risk of type 2 diabetes mellitus (T2D). However, less is known about other cardiac stress biomarkers in this context. Here we evaluated the association of mid-regional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine vasopressin (copeptin), C-terminal pro-endothelin-1 (CT-proET-1) and mid-regional pro-adrenomedullin (MR-proADM) with incident T2D and changes in glucose metabolism. Methods: We performed a prospective cohort study using data from the population-based KORA F4/FF4 study. 1773 participants (52.3% women) with MR-proANP measurements and 960 (52.7% women) with copeptin, CT-proET-1 and MR-proADM measurements were included. We examined associations of circulating plasma levels of MR-proANP, copeptin, CT-proET-1 and MR-proADM with incident T2D, the combined endpoint of incident prediabetes/T2D and with fasting and 2 h-glucose, fasting insulin, HOMA-IR, HOMA-B and HbA1c at follow-up. Logistic and linear regression models adjusted for age, sex, waist circumference, height, hypertension, total/HDL cholesterol ratio, triglycerides, smoking, physical activity and parental history of diabetes were used to compute effect estimates. Results: During a median follow-up time of 6.4 years (25th and 75th percentiles: 6.0 and 6.6, respectively), 119 out of the 1773 participants and 72 out of the 960 participants developed T2D. MR-proANP was inversely associated with incident T2D (odds ratio [95% confidence interval]: 0.75 [0.58; 0.96] per 1-SD increase of log MR-proANP). Copeptin was positively associated with incident prediabetes/T2D (1.29 [1.02; 1.63] per 1-SD increase of log copeptin). Elevated levels of CT-proET-1 were associated with increased HOMA-B at follow-up, while elevated MR-proADM levels were associated with increased fasting insulin, HOMA-IR and HOMA-B at follow-up. These associations were independent of previously described diabetes risk factors. Conclusions: High plasma concentrations of MR-proANP contributed to a lower risk of incident T2D, whereas high plasma concentrations of copeptin were associated with an increased risk of incident prediabetes/T2D. Furthermore, high plasma concentrations of CT-proET-1 and MR-proADM were associated with increased insulin resistance. Our study provides evidence that biomarkers implicated in cardiac stress are associated with incident T2D and changes in glucose metabolism.

Item URL in elib:https://elib.dlr.de/140019/
Document Type:Article
Title:Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Sujana, ChaterinaInstitute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germanyhttps://orcid.org/0000-0002-0663-2557
Seissler, JochenMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, GermanyUNSPECIFIED
Jordan, JensInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Rathmann, WolfgangInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, GermanyUNSPECIFIED
Koenig, WolfgangDeutsches Herzzentrum München, Technische Universität München, Munich, Germanyhttps://orcid.org/0000-0002-2064-9603
Roden, MichaelGerman Center for Diabetes Research (DZD), Munich-Neuherberg, Germanyhttps://orcid.org/0000-0001-8200-6382
Mansmann, UlrichInstitute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-Universität, Munich, GermanyUNSPECIFIED
Herder, ChristianGerman Center for Diabetes Research (DZD), Munich-Neuherberg, GermanyUNSPECIFIED
Peters, AnnetteInstitute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, GermanyUNSPECIFIED
Thorand, BarbaraInstitute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany. thorand (at) helmholtz-muenchen.dehttps://orcid.org/0000-0002-8416-6440
Then, CorneliaMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, GermanyUNSPECIFIED
Date:16 October 2020
Journal or Publication Title:Cardiovascular Diabetology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:19
DOI :10.1186/s12933-020-01117-1
Page Range:p. 178
Publisher:BioMed Central
ISSN:1475-2840
Status:Published
Keywords:CT-proET-1; Cardiac stress biomarkers; Cohort study; Copeptin; Incidence; Insulin resistance; MR-proADM; MR-proANP; Prediabetes; Type 2 diabetes
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:11 Jan 2021 14:20
Last Modified:11 Jan 2021 14:20

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