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Stability Studies of Starch Aerogel Formulations for Biomedical Applications

Santos-Rosales, Victor and Alvarez-Rivera, Gerardo and Hillgärtner, Markus and Cifuentes, Alejandro and Itskov, Mikhail and Garcia-Gonzalez, Carlos A. and Rege, Ameya Govind (2020) Stability Studies of Starch Aerogel Formulations for Biomedical Applications. Biomacromolecules, 21 (12), pp. 5336-5344. American Chemical Society (ACS). doi: 10.1021/acs.biomac.0c01414. ISSN 1526-4602.

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Official URL: https://pubs.acs.org/doi/10.1021/acs.biomac.0c01414

Abstract

Starch aerogels are attractive materials for biomedical applications because of their low density and high open porosity coupled with high surface areas. However, the lack of macropores in conventionally manufactured polysaccharide aerogels is a limitation to their use as scaffolds for regenerative medicine. Moreover, the stability under storage of polysaccharide aerogels is critical for biomedical purposes and scarcely studied so far. In this work, the induction of a new macropore population (1–2 μm) well integrated into the starch aerogel backbone was successfully achieved by the incorporation of zein as a porogen. The obtained dual-porous aerogels were evaluated in terms of composition as well as morphological, textural, and mechanical properties. Stability of aerogels upon storage mimicking the zone II (25 °C, 65% relative humidity) according to the International Council for Harmonization guideline of climatic conditions was checked after 1 and 3 months from morphological, physicochemical, and mechanical perspectives. Zein incorporation induced remarkable changes in the mechanical performance of the end aerogel products and showed a preventive effect on the morphological changes during the storage period.

Item URL in elib:https://elib.dlr.de/139711/
Document Type:Article
Title:Stability Studies of Starch Aerogel Formulations for Biomedical Applications
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Santos-Rosales, VictorUNSPECIFIEDUNSPECIFIED
Alvarez-Rivera, GerardoCSIC MadridUNSPECIFIED
Hillgärtner, MarkusRWTH Aachen UniversityUNSPECIFIED
Cifuentes, AlejandroCSIC MadridUNSPECIFIED
Itskov, MikhailRWTH Aachen UniversityUNSPECIFIED
Garcia-Gonzalez, Carlos A.Universidade de Santiago de CompostelaUNSPECIFIED
Rege, Ameya GovindUNSPECIFIEDhttps://orcid.org/0000-0001-9564-5482
Date:1 December 2020
Journal or Publication Title:Biomacromolecules
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:21
DOI:10.1021/acs.biomac.0c01414
Page Range:pp. 5336-5344
Publisher:American Chemical Society (ACS)
ISSN:1526-4602
Status:Published
Keywords:aerogel, starch, zein, mechanical behavior, storage
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Transport
HGF - Program Themes:Road Transport
DLR - Research area:Transport
DLR - Program:V ST Straßenverkehr
DLR - Research theme (Project):V - NGC Fahrzeugstruktur II
Location: Köln-Porz
Institutes and Institutions:Institute of Materials Research > Aerogels and Aerogel Composites
Deposited By: Rege, Dr. Ameya Govind
Deposited On:14 Jan 2021 07:35
Last Modified:14 Jan 2021 07:35

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