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Unchanged cerebrovascular CO₂ reactivity and hypercapnic ventilatory response during strict head-down tilt bed rest in a mild hypercapnic environment

Laurie, S.S. and Christian, K. and Kysar, J. and M.C. Lee, S. and Lovering, A.T. and Macias, B.R. and Moestl, S. and Sies, W. and Mulder, E. and Young, M. and Stenger, M.B. (2020) Unchanged cerebrovascular CO₂ reactivity and hypercapnic ventilatory response during strict head-down tilt bed rest in a mild hypercapnic environment. The Journal of Physiology, 598 (12), pp. 2491-2505. Wiley. doi: 10.1113/JP279383. ISSN 0022-3751.

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Official URL: https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP279383

Abstract

Chronically elevated carbon dioxide (CO₂) levels can occur in confined spaces such as the International Space Station. Using the spaceflight analogue 30 days of strict 6° head-down tilt bed rest (HDTBR) in a mild hypercapnic environment ( PCO₂ = 4 mmHg), we investigated arterialized PCO₂, cerebrovascular reactivity and the hypercapnic ventilatory response in 11 healthy subjects (five females) before, on days 1, 9, 15 and 30 of bed rest (BR), and 6 and 13 days after HDTBR. During all HDTBR time points, arterialized PCO₂ was not significantly different from the pre-HDTBR measured in the 6° HDT posture, with a mean (95% confidence interval) increase of 1.2 mmHg (–0.2 to 2.5 mmHg, P = 0.122) on day 30 of HDTBR. Respiratory acidosis was never detected, although a mild metabolic alkalosis developed on day 30 of HDTBR by a mean (95% confidence interval) pH change of 0.032 (0.022–0.043; P < 0.001), which remained elevated by 0.021 (0.011–0.031; P < 0.001) 6 days after HDTBR. Arterialized pH returned to pre-HDTBR levels 13 days after BR with a change of –0.001 (–0.009 to 0.007; P = 0.991).

Item URL in elib:https://elib.dlr.de/137106/
Document Type:Article
Title:Unchanged cerebrovascular CO₂ reactivity and hypercapnic ventilatory response during strict head-down tilt bed rest in a mild hypercapnic environment
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Laurie, S.S.KBRwyleUNSPECIFIED
Christian, K.Department of Human Physiology, University of Oregon, Eugene, OR, USAUNSPECIFIED
Kysar, J.Department of Human Physiology, University of Oregon, Eugene, OR, USAUNSPECIFIED
M.C. Lee, S.KBR, Houston, TX, USAUNSPECIFIED
Lovering, A.T.Department of Human Physiology, University of Oregon, Eugene, OR, USAUNSPECIFIED
Macias, B.R.KBRwyleUNSPECIFIED
Moestl, S.German Aerospace Center, Cologne, GermanyUNSPECIFIED
Sies, W.wolfram.sies (at) dlr.deUNSPECIFIED
Mulder, E.german aerospace center (dlr), institute of aerospace medicine, biomedical science support center, cologne, germanyUNSPECIFIED
Young, M.Biomedical Research and Environmental Sciences Division, Human Health and Performance Directorate, NASA Johnson Space Center, Houston, TX, USAUNSPECIFIED
Stenger, M.B.NASA Johnson Space Center, Houston, TX, USAUNSPECIFIED
Date:June 2020
Journal or Publication Title:The Journal of Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:598
DOI :10.1113/JP279383
Page Range:pp. 2491-2505
Publisher:Wiley
ISSN:0022-3751
Status:Published
Keywords:hypercapnic ventilatory, bed rest, hypercapnic environment, cerebrovascular CO₂ reactivity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Arndt, Carina
Deposited On:05 Nov 2020 17:32
Last Modified:05 Nov 2020 17:32

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